<i>N</i>-Benzyl Residues as the P1′ Substituents in Phosphorus-Containing Extended Transition State Analog Inhibitors of Metalloaminopeptidases

<i>N</i>-Benzyl Residues as the P1′ Substituents in Phosphorus-Containing Extended Transition State Analog Inhibitors of Metalloaminopeptidases

Peptidyl enzyme inhibitors containing an internal aminomethylphosphinic bond system (P(O)(OH)-CH<sub>2</sub>-NH) can be termed extended transition state analogs by similarity to the corresponding phosphonamidates (P(O)(OH)-NH). Phosphonamidate pseudopeptides are broadly recognized as com...

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Bibliographic Details
Main Authors: Kamila Janiszewska, Michał Talma, Bartosz Oszywa, Małgorzata Pawełczak, Paweł Kafarski, Artur Mucha
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
organophosphorus compounds
peptide analogs
enzyme inhibitors
ligand-enzyme interactions
molecular modeling and docking
Online Access:https://www.mdpi.com/1420-3049/25/18/4334

Internet

https://www.mdpi.com/1420-3049/25/18/4334

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