Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential
It is estimated that 30 % of the world's population harbours the parasite Toxoplasma gondii, particularly in the brain. Beyond its implication in potentially severe opportunistic or congenital infections, this persistence has long been considered as without consequence. However, certain data in...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023093556 |
| _version_ | 1797429704793260032 |
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| author | D. Dupont M.G. Robert M.P. Brenier-Pinchart A. Lefevre M. Wallon H. Pelloux |
| author_facet | D. Dupont M.G. Robert M.P. Brenier-Pinchart A. Lefevre M. Wallon H. Pelloux |
| author_sort | D. Dupont |
| collection | DOAJ |
| description | It is estimated that 30 % of the world's population harbours the parasite Toxoplasma gondii, particularly in the brain. Beyond its implication in potentially severe opportunistic or congenital infections, this persistence has long been considered as without consequence. However, certain data in animals and humans suggest that this carriage may be linked to various neuropsychiatric or neurodegenerative disorders. The hypothesis of a potential cerebral oncogenicity of the parasite is also emerging.In this personal view, we will present the epidemiological arguments in favour of an association between toxoplasmosis and cerebral malignancy, before considering the points that could underlie a potential causal link. More specifically, we will focus on the brain as the preferred location for T. gondii persistence and the propensity of this parasite to interfere with the apoptosis and cell cycle signalling pathways of their host cell. |
| first_indexed | 2024-03-09T09:17:00Z |
| format | Article |
| id | doaj.art-9a3535e0e5af48508c95e774ab1cfe35 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-09T09:17:00Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-9a3535e0e5af48508c95e774ab1cfe352023-12-02T07:05:19ZengElsevierHeliyon2405-84402023-11-01911e22147Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potentialD. Dupont0M.G. Robert1M.P. Brenier-Pinchart2A. Lefevre3M. Wallon4H. Pelloux5Institut des Agents Infectieux, Parasitologie Mycologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, 69004, France; Physiologie intégrée du système d’éveil, Centre de Recherche en Neurosciences de Lyon, INSERM U1028-CNRS UMR 5292, Faculté de Médecine, Université Claude Bernard Lyon 1, Bron, 69500, France; Corresponding author. Institut des Agents Infectieux, Parasitologie Mycologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, 69004, France.Service de Parasitologie-Mycologie, CHU Grenoble Alpes, Grenoble, 38000, France; Université Grenoble Alpes, Institut pour l'Avancée des Biosciences (IAB), INSERM U1209-CNRS UMR 5309, Grenoble, 38000, FranceService de Parasitologie-Mycologie, CHU Grenoble Alpes, Grenoble, 38000, France; Université Grenoble Alpes, Institut pour l'Avancée des Biosciences (IAB), INSERM U1209-CNRS UMR 5309, Grenoble, 38000, FranceInstitut des Agents Infectieux, Parasitologie Mycologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, 69004, FranceInstitut des Agents Infectieux, Parasitologie Mycologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, 69004, France; Physiologie intégrée du système d’éveil, Centre de Recherche en Neurosciences de Lyon, INSERM U1028-CNRS UMR 5292, Faculté de Médecine, Université Claude Bernard Lyon 1, Bron, 69500, FranceService de Parasitologie-Mycologie, CHU Grenoble Alpes, Grenoble, 38000, France; Université Grenoble Alpes, Institut pour l'Avancée des Biosciences (IAB), INSERM U1209-CNRS UMR 5309, Grenoble, 38000, FranceIt is estimated that 30 % of the world's population harbours the parasite Toxoplasma gondii, particularly in the brain. Beyond its implication in potentially severe opportunistic or congenital infections, this persistence has long been considered as without consequence. However, certain data in animals and humans suggest that this carriage may be linked to various neuropsychiatric or neurodegenerative disorders. The hypothesis of a potential cerebral oncogenicity of the parasite is also emerging.In this personal view, we will present the epidemiological arguments in favour of an association between toxoplasmosis and cerebral malignancy, before considering the points that could underlie a potential causal link. More specifically, we will focus on the brain as the preferred location for T. gondii persistence and the propensity of this parasite to interfere with the apoptosis and cell cycle signalling pathways of their host cell.http://www.sciencedirect.com/science/article/pii/S2405844023093556ToxoplasmaBrainCancerApoptosisCell cycle |
| spellingShingle | D. Dupont M.G. Robert M.P. Brenier-Pinchart A. Lefevre M. Wallon H. Pelloux Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential Heliyon Toxoplasma Brain Cancer Apoptosis Cell cycle |
| title | Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential |
| title_full | Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential |
| title_fullStr | Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential |
| title_full_unstemmed | Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential |
| title_short | Toxoplasma gondii, a plea for a thorough investigation of its oncogenic potential |
| title_sort | toxoplasma gondii a plea for a thorough investigation of its oncogenic potential |
| topic | Toxoplasma Brain Cancer Apoptosis Cell cycle |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023093556 |
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