Creation of an open-access, mutation-defined fibroblast resource for neurological disease research.
Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying mole...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3428297?pdf=render |
| _version_ | 1819159276423217152 |
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| author | Selina Wray Matthew Self NINDS Parkinson's Disease iPSC Consortium NINDS Huntington's Disease iPSC Consortium NINDS ALS iPSC Consortium Patrick A Lewis Jan-Willem Taanman Natalie S Ryan Colin J Mahoney Yuying Liang Michael J Devine Una-Marie Sheerin Henry Houlden Huw R Morris Daniel Healy Jose-Felix Marti-Masso Elisavet Preza Suzanne Barker Margaret Sutherland Roderick A Corriveau Michael D'Andrea Anthony H V Schapira Ryan J Uitti Mark Guttman Grzegorz Opala Barbara Jasinska-Myga Andreas Puschmann Christer Nilsson Alberto J Espay Jaroslaw Slawek Ludwig Gutmann Bradley F Boeve Kevin Boylan A Jon Stoessl Owen A Ross Nicholas J Maragakis Jay Van Gerpen Melissa Gerstenhaber Katrina Gwinn Ted M Dawson Ole Isacson Karen S Marder Lorraine N Clark Serge E Przedborski Steven Finkbeiner Jeffrey D Rothstein Zbigniew K Wszolek Martin N Rossor John Hardy |
| author_facet | Selina Wray Matthew Self NINDS Parkinson's Disease iPSC Consortium NINDS Huntington's Disease iPSC Consortium NINDS ALS iPSC Consortium Patrick A Lewis Jan-Willem Taanman Natalie S Ryan Colin J Mahoney Yuying Liang Michael J Devine Una-Marie Sheerin Henry Houlden Huw R Morris Daniel Healy Jose-Felix Marti-Masso Elisavet Preza Suzanne Barker Margaret Sutherland Roderick A Corriveau Michael D'Andrea Anthony H V Schapira Ryan J Uitti Mark Guttman Grzegorz Opala Barbara Jasinska-Myga Andreas Puschmann Christer Nilsson Alberto J Espay Jaroslaw Slawek Ludwig Gutmann Bradley F Boeve Kevin Boylan A Jon Stoessl Owen A Ross Nicholas J Maragakis Jay Van Gerpen Melissa Gerstenhaber Katrina Gwinn Ted M Dawson Ole Isacson Karen S Marder Lorraine N Clark Serge E Przedborski Steven Finkbeiner Jeffrey D Rothstein Zbigniew K Wszolek Martin N Rossor John Hardy |
| author_sort | Selina Wray |
| collection | DOAJ |
| description | Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying molecular pathology. Recently, there has been a surge of interest in the use of patient-derived cells, due to the development of induced pluripotent stem cells and their subsequent differentiation into neurons and glia. Access to patient cell lines carrying the relevant mutations is a limiting factor for many centres wishing to pursue this research. We have therefore generated an open-access collection of fibroblast lines from patients carrying mutations linked to neurological disease. These cell lines have been deposited in the National Institute for Neurological Disorders and Stroke (NINDS) Repository at the Coriell Institute for Medical Research and can be requested by any research group for use in in vitro disease modelling. There are currently 71 mutation-defined cell lines available for request from a wide range of neurological disorders and this collection will be continually expanded. This represents a significant resource that will advance the use of patient cells as disease models by the scientific community. |
| first_indexed | 2024-12-22T16:37:59Z |
| format | Article |
| id | doaj.art-9a35e1d7ec9b460c9b9c8d8637a681ec |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T16:37:59Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9a35e1d7ec9b460c9b9c8d8637a681ec2022-12-21T18:19:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0178e4309910.1371/journal.pone.0043099Creation of an open-access, mutation-defined fibroblast resource for neurological disease research.Selina WrayMatthew SelfNINDS Parkinson's Disease iPSC ConsortiumNINDS Huntington's Disease iPSC ConsortiumNINDS ALS iPSC ConsortiumPatrick A LewisJan-Willem TaanmanNatalie S RyanColin J MahoneyYuying LiangMichael J DevineUna-Marie SheerinHenry HouldenHuw R MorrisDaniel HealyJose-Felix Marti-MassoElisavet PrezaSuzanne BarkerMargaret SutherlandRoderick A CorriveauMichael D'AndreaAnthony H V SchapiraRyan J UittiMark GuttmanGrzegorz OpalaBarbara Jasinska-MygaAndreas PuschmannChrister NilssonAlberto J EspayJaroslaw SlawekLudwig GutmannBradley F BoeveKevin BoylanA Jon StoesslOwen A RossNicholas J MaragakisJay Van GerpenMelissa GerstenhaberKatrina GwinnTed M DawsonOle IsacsonKaren S MarderLorraine N ClarkSerge E PrzedborskiSteven FinkbeinerJeffrey D RothsteinZbigniew K WszolekMartin N RossorJohn HardyOur understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying molecular pathology. Recently, there has been a surge of interest in the use of patient-derived cells, due to the development of induced pluripotent stem cells and their subsequent differentiation into neurons and glia. Access to patient cell lines carrying the relevant mutations is a limiting factor for many centres wishing to pursue this research. We have therefore generated an open-access collection of fibroblast lines from patients carrying mutations linked to neurological disease. These cell lines have been deposited in the National Institute for Neurological Disorders and Stroke (NINDS) Repository at the Coriell Institute for Medical Research and can be requested by any research group for use in in vitro disease modelling. There are currently 71 mutation-defined cell lines available for request from a wide range of neurological disorders and this collection will be continually expanded. This represents a significant resource that will advance the use of patient cells as disease models by the scientific community.http://europepmc.org/articles/PMC3428297?pdf=render |
| spellingShingle | Selina Wray Matthew Self NINDS Parkinson's Disease iPSC Consortium NINDS Huntington's Disease iPSC Consortium NINDS ALS iPSC Consortium Patrick A Lewis Jan-Willem Taanman Natalie S Ryan Colin J Mahoney Yuying Liang Michael J Devine Una-Marie Sheerin Henry Houlden Huw R Morris Daniel Healy Jose-Felix Marti-Masso Elisavet Preza Suzanne Barker Margaret Sutherland Roderick A Corriveau Michael D'Andrea Anthony H V Schapira Ryan J Uitti Mark Guttman Grzegorz Opala Barbara Jasinska-Myga Andreas Puschmann Christer Nilsson Alberto J Espay Jaroslaw Slawek Ludwig Gutmann Bradley F Boeve Kevin Boylan A Jon Stoessl Owen A Ross Nicholas J Maragakis Jay Van Gerpen Melissa Gerstenhaber Katrina Gwinn Ted M Dawson Ole Isacson Karen S Marder Lorraine N Clark Serge E Przedborski Steven Finkbeiner Jeffrey D Rothstein Zbigniew K Wszolek Martin N Rossor John Hardy Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. PLoS ONE |
| title | Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. |
| title_full | Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. |
| title_fullStr | Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. |
| title_full_unstemmed | Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. |
| title_short | Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. |
| title_sort | creation of an open access mutation defined fibroblast resource for neurological disease research |
| url | http://europepmc.org/articles/PMC3428297?pdf=render |
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