Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant <i>Withania somnifera</i> (L.) Dunal
Cancer represents the second most deadly disease and one of the most important public health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy are the major types of treatment strategies that have been implemented in cancer treatment. Unfortunately, these treatment opt...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/2/160 |
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| author | Suneel Kumar Stephen O. Mathew Ravindra Prasad Aharwal Hardeep Singh Tulli Chakrabhavi Dhananjaya Mohan Gautam Sethi Kwang-Seok Ahn Kassidy Webber Sardul Singh Sandhu Anupam Bishayee |
| author_facet | Suneel Kumar Stephen O. Mathew Ravindra Prasad Aharwal Hardeep Singh Tulli Chakrabhavi Dhananjaya Mohan Gautam Sethi Kwang-Seok Ahn Kassidy Webber Sardul Singh Sandhu Anupam Bishayee |
| author_sort | Suneel Kumar |
| collection | DOAJ |
| description | Cancer represents the second most deadly disease and one of the most important public health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy are the major types of treatment strategies that have been implemented in cancer treatment. Unfortunately, these treatment options suffer from major limitations, such as drug-resistance and adverse effects, which may eventually result in disease recurrence. Many phytochemicals have been investigated for their antitumor efficacy in preclinical models and clinical studies to discover newer therapeutic agents with fewer adverse effects. Withaferin A, a natural bioactive molecule isolated from the Indian medicinal plant <i>Withania somnifera</i> (L.) Dunal, has been reported to impart anticancer activities against various cancer cell lines and preclinical cancer models by modulating the expression and activity of different oncogenic proteins. In this article, we have comprehensively discussed the biosynthesis of withaferin A as well as its antineoplastic activities and mode-of-action in in vitro and in vivo settings. We have also reviewed the effect of withaferin A on the expression of miRNAs, its combinational effect with other cytotoxic agents, withaferin A-based formulations, safety and toxicity profiles, and its clinical potential. |
| first_indexed | 2024-03-11T08:18:06Z |
| format | Article |
| id | doaj.art-9a36679832be4735aff744f0e9f34c6a |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T08:18:06Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-9a36679832be4735aff744f0e9f34c6a2023-11-16T22:35:51ZengMDPI AGPharmaceuticals1424-82472023-01-0116216010.3390/ph16020160Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant <i>Withania somnifera</i> (L.) DunalSuneel Kumar0Stephen O. Mathew1Ravindra Prasad Aharwal2Hardeep Singh Tulli3Chakrabhavi Dhananjaya Mohan4Gautam Sethi5Kwang-Seok Ahn6Kassidy Webber7Sardul Singh Sandhu8Anupam Bishayee9Bio-Design Innovation Centre, Rani Durgavati University, Jabalpur 482 001, IndiaDepartment of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, TX 76107, USADepartment of Botany, Government College Kurai, Seoni 480 880, IndiaDepartment of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala 133 207, IndiaDepartment of Studies in Molecular Biology, University of Mysore, Mysuru 570 006, IndiaDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDepartment of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaCollege of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USABio-Design Innovation Centre, Rani Durgavati University, Jabalpur 482 001, IndiaCollege of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, FL 34211, USACancer represents the second most deadly disease and one of the most important public health concerns worldwide. Surgery, chemotherapy, radiation therapy, and immune therapy are the major types of treatment strategies that have been implemented in cancer treatment. Unfortunately, these treatment options suffer from major limitations, such as drug-resistance and adverse effects, which may eventually result in disease recurrence. Many phytochemicals have been investigated for their antitumor efficacy in preclinical models and clinical studies to discover newer therapeutic agents with fewer adverse effects. Withaferin A, a natural bioactive molecule isolated from the Indian medicinal plant <i>Withania somnifera</i> (L.) Dunal, has been reported to impart anticancer activities against various cancer cell lines and preclinical cancer models by modulating the expression and activity of different oncogenic proteins. In this article, we have comprehensively discussed the biosynthesis of withaferin A as well as its antineoplastic activities and mode-of-action in in vitro and in vivo settings. We have also reviewed the effect of withaferin A on the expression of miRNAs, its combinational effect with other cytotoxic agents, withaferin A-based formulations, safety and toxicity profiles, and its clinical potential.https://www.mdpi.com/1424-8247/16/2/160withaferin Acancerapoptosisangiogenesischemoresistanceformulations |
| spellingShingle | Suneel Kumar Stephen O. Mathew Ravindra Prasad Aharwal Hardeep Singh Tulli Chakrabhavi Dhananjaya Mohan Gautam Sethi Kwang-Seok Ahn Kassidy Webber Sardul Singh Sandhu Anupam Bishayee Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant <i>Withania somnifera</i> (L.) Dunal Pharmaceuticals withaferin A cancer apoptosis angiogenesis chemoresistance formulations |
| title | Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant <i>Withania somnifera</i> (L.) Dunal |
| title_full | Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant <i>Withania somnifera</i> (L.) Dunal |
| title_fullStr | Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant <i>Withania somnifera</i> (L.) Dunal |
| title_full_unstemmed | Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant <i>Withania somnifera</i> (L.) Dunal |
| title_short | Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant <i>Withania somnifera</i> (L.) Dunal |
| title_sort | withaferin a a pleiotropic anticancer agent from the indian medicinal plant i withania somnifera i l dunal |
| topic | withaferin A cancer apoptosis angiogenesis chemoresistance formulations |
| url | https://www.mdpi.com/1424-8247/16/2/160 |
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