Membrane estrogen receptor alpha (ERα) participates in flow-mediated dilation in a ligand-independent manner

Membrane estrogen receptor alpha (ERα) participates in flow-mediated dilation in a ligand-independent manner

Estrogen receptor alpha (ERα) activation by estrogens prevents atheroma through its nuclear action, whereas plasma membrane-located ERα accelerates endothelial healing. The genetic deficiency of ERα was associated with a reduction in flow-mediated dilation (FMD) in one man. Here, we evaluated ex viv...

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Bibliographic Details
Main Authors: Julie Favre, Emilie Vessieres, Anne-Laure Guihot, Coralyne Proux, Linda Grimaud, Jordan Rivron, Manuela CL Garcia, Léa Réthoré, Rana Zahreddine, Morgane Davezac, Chanaelle Fébrissy, Marine Adlanmerini, Laurent Loufrani, Vincent Procaccio, Jean-Michel Foidart, Gilles Flouriot, Françoise Lenfant, Coralie Fontaine, Jean-François Arnal, Daniel Henrion
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-11-01
Series:eLife
Subjects:
endothelium
shear stress
estrogen receptors
blood flow
resistance arteries
Online Access:https://elifesciences.org/articles/68695

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