High overlap in patients diagnosed with hypermobile Ehlers-Danlos syndrome or hypermobile spectrum disorders with fibromyalgia and 40 self-reported symptoms and comorbidities
BackgroundJoint pain is a common symptom in patients with hypermobile Ehlers-Danlos Syndrome (hEDS), hypermobility spectrum disorders (HSD) and fibromyalgia. The goal of this study was to determine whether symptoms and comorbidities overlap in patients diagnosed with hEDS/HSD and/or fibromyalgia.Met...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-04-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1096180/full |
| _version_ | 1797840024269488128 |
|---|---|
| author | DeLisa Fairweather Katelyn A. Bruno Katelyn A. Bruno Ashley A. Darakjian Barbara K. Bruce Jessica M. Gehin Archana Kotha Angita Jain Zhongwei Peng David O. Hodge Todd D. Rozen Bala Munipalli Fernando A. Rivera Pedro A. Malavet Dacre R. T. Knight |
| author_facet | DeLisa Fairweather Katelyn A. Bruno Katelyn A. Bruno Ashley A. Darakjian Barbara K. Bruce Jessica M. Gehin Archana Kotha Angita Jain Zhongwei Peng David O. Hodge Todd D. Rozen Bala Munipalli Fernando A. Rivera Pedro A. Malavet Dacre R. T. Knight |
| author_sort | DeLisa Fairweather |
| collection | DOAJ |
| description | BackgroundJoint pain is a common symptom in patients with hypermobile Ehlers-Danlos Syndrome (hEDS), hypermobility spectrum disorders (HSD) and fibromyalgia. The goal of this study was to determine whether symptoms and comorbidities overlap in patients diagnosed with hEDS/HSD and/or fibromyalgia.MethodsWe retrospectively examined self-reported data from an EDS Clinic intake questionnaire in patients diagnosed with hEDS/HSD, fibromyalgia, or both vs. controls with an emphasis on joint issues.ResultsFrom 733 patients seen at the EDS Clinic, 56.5% (n = 414) were diagnosed with hEDS/HSD and fibromyalgia (Fibro), 23.8% (n = 167) hEDS/HSD, 13.3% (n = 98) fibromyalgia, or 7.4% (n = 54) none of these diagnoses. More patients were diagnosed with HSD (76.6%) than hEDS (23.4%). Patients were primarily White (95%) and female (90%) with a median age in their 30s (controls 36.7 [18.0, 70.0], fibromyalgia 39.7 [18.0, 75.0], hEDS/HSD 35.0 [18.0, 71.0], hEDS/HSD&Fibro 31.0 [18.0, 63.0]). There was high overlap in all 40 symptoms/comorbidities that we examined in patients diagnosed with fibromyalgia only or hEDS/HSD&Fibro, regardless of whether they had hEDS or HSD. Patients that only had hEDS/HSD without fibromyalgia had far fewer symptoms/comorbidities than patients with hEDS/HSD&Fibro. The top self-reported issues in patients that only had fibromyalgia were joint pain, hand pain when writing or typing, brain fog, joint pain keeping from daily activities, allergy/atopy and headache. Five issues that significantly and uniquely characterized patients diagnosed with hEDS/HSD&Fibro were subluxations (dislocations in hEDS patients), joint issues like sprains, the need to stop sports due to injuries, poor wound healing, and migraine.ConclusionThe majority of patients seen at the EDS Clinic had a diagnosis of hEDS/HSD plus fibromyalgia that was associated with more severe disease. Our findings indicate that fibromyalgia should be routinely assessed in patients with hEDS/HSD and vis-a-versa to improve patient care. |
| first_indexed | 2024-04-09T16:07:44Z |
| format | Article |
| id | doaj.art-9a38cc6f5b624b20a5b7c3be90f83883 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-09T16:07:44Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-9a38cc6f5b624b20a5b7c3be90f838832023-04-25T04:38:38ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-04-011010.3389/fmed.2023.10961801096180High overlap in patients diagnosed with hypermobile Ehlers-Danlos syndrome or hypermobile spectrum disorders with fibromyalgia and 40 self-reported symptoms and comorbiditiesDeLisa Fairweather0Katelyn A. Bruno1Katelyn A. Bruno2Ashley A. Darakjian3Barbara K. Bruce4Jessica M. Gehin5Archana Kotha6Angita Jain7Zhongwei Peng8David O. Hodge9Todd D. Rozen10Bala Munipalli11Fernando A. Rivera12Pedro A. Malavet13Dacre R. T. Knight14Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United StatesDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United StatesDivision of Cardiovascular Medicine, University of Florida, Gainesville, FL, United StatesDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United StatesDepartment of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, United StatesDepartment of General Internal Medicine, Mayo Clinic, Jacksonville, FL, United StatesDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United StatesDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, United StatesDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, United StatesDepartment of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, United StatesDepartment of Neurology, Mayo Clinic, Jacksonville, FL, United StatesDepartment of General Internal Medicine, Mayo Clinic, Jacksonville, FL, United StatesDepartment of General Internal Medicine, Mayo Clinic, Jacksonville, FL, United StatesDepartment of General Internal Medicine, Mayo Clinic, Jacksonville, FL, United StatesDepartment of General Internal Medicine, Mayo Clinic, Jacksonville, FL, United StatesBackgroundJoint pain is a common symptom in patients with hypermobile Ehlers-Danlos Syndrome (hEDS), hypermobility spectrum disorders (HSD) and fibromyalgia. The goal of this study was to determine whether symptoms and comorbidities overlap in patients diagnosed with hEDS/HSD and/or fibromyalgia.MethodsWe retrospectively examined self-reported data from an EDS Clinic intake questionnaire in patients diagnosed with hEDS/HSD, fibromyalgia, or both vs. controls with an emphasis on joint issues.ResultsFrom 733 patients seen at the EDS Clinic, 56.5% (n = 414) were diagnosed with hEDS/HSD and fibromyalgia (Fibro), 23.8% (n = 167) hEDS/HSD, 13.3% (n = 98) fibromyalgia, or 7.4% (n = 54) none of these diagnoses. More patients were diagnosed with HSD (76.6%) than hEDS (23.4%). Patients were primarily White (95%) and female (90%) with a median age in their 30s (controls 36.7 [18.0, 70.0], fibromyalgia 39.7 [18.0, 75.0], hEDS/HSD 35.0 [18.0, 71.0], hEDS/HSD&Fibro 31.0 [18.0, 63.0]). There was high overlap in all 40 symptoms/comorbidities that we examined in patients diagnosed with fibromyalgia only or hEDS/HSD&Fibro, regardless of whether they had hEDS or HSD. Patients that only had hEDS/HSD without fibromyalgia had far fewer symptoms/comorbidities than patients with hEDS/HSD&Fibro. The top self-reported issues in patients that only had fibromyalgia were joint pain, hand pain when writing or typing, brain fog, joint pain keeping from daily activities, allergy/atopy and headache. Five issues that significantly and uniquely characterized patients diagnosed with hEDS/HSD&Fibro were subluxations (dislocations in hEDS patients), joint issues like sprains, the need to stop sports due to injuries, poor wound healing, and migraine.ConclusionThe majority of patients seen at the EDS Clinic had a diagnosis of hEDS/HSD plus fibromyalgia that was associated with more severe disease. Our findings indicate that fibromyalgia should be routinely assessed in patients with hEDS/HSD and vis-a-versa to improve patient care.https://www.frontiersin.org/articles/10.3389/fmed.2023.1096180/fullfibromyalgiahypermobile Ehlers-Danlos syndrome (hEDS)hypermobility spectrum disorderschronic diseasepainabuse |
| spellingShingle | DeLisa Fairweather Katelyn A. Bruno Katelyn A. Bruno Ashley A. Darakjian Barbara K. Bruce Jessica M. Gehin Archana Kotha Angita Jain Zhongwei Peng David O. Hodge Todd D. Rozen Bala Munipalli Fernando A. Rivera Pedro A. Malavet Dacre R. T. Knight High overlap in patients diagnosed with hypermobile Ehlers-Danlos syndrome or hypermobile spectrum disorders with fibromyalgia and 40 self-reported symptoms and comorbidities Frontiers in Medicine fibromyalgia hypermobile Ehlers-Danlos syndrome (hEDS) hypermobility spectrum disorders chronic disease pain abuse |
| title | High overlap in patients diagnosed with hypermobile Ehlers-Danlos syndrome or hypermobile spectrum disorders with fibromyalgia and 40 self-reported symptoms and comorbidities |
| title_full | High overlap in patients diagnosed with hypermobile Ehlers-Danlos syndrome or hypermobile spectrum disorders with fibromyalgia and 40 self-reported symptoms and comorbidities |
| title_fullStr | High overlap in patients diagnosed with hypermobile Ehlers-Danlos syndrome or hypermobile spectrum disorders with fibromyalgia and 40 self-reported symptoms and comorbidities |
| title_full_unstemmed | High overlap in patients diagnosed with hypermobile Ehlers-Danlos syndrome or hypermobile spectrum disorders with fibromyalgia and 40 self-reported symptoms and comorbidities |
| title_short | High overlap in patients diagnosed with hypermobile Ehlers-Danlos syndrome or hypermobile spectrum disorders with fibromyalgia and 40 self-reported symptoms and comorbidities |
| title_sort | high overlap in patients diagnosed with hypermobile ehlers danlos syndrome or hypermobile spectrum disorders with fibromyalgia and 40 self reported symptoms and comorbidities |
| topic | fibromyalgia hypermobile Ehlers-Danlos syndrome (hEDS) hypermobility spectrum disorders chronic disease pain abuse |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1096180/full |
| work_keys_str_mv | AT delisafairweather highoverlapinpatientsdiagnosedwithhypermobileehlersdanlossyndromeorhypermobilespectrumdisorderswithfibromyalgiaand40selfreportedsymptomsandcomorbidities AT katelynabruno highoverlapinpatientsdiagnosedwithhypermobileehlersdanlossyndromeorhypermobilespectrumdisorderswithfibromyalgiaand40selfreportedsymptomsandcomorbidities AT katelynabruno highoverlapinpatientsdiagnosedwithhypermobileehlersdanlossyndromeorhypermobilespectrumdisorderswithfibromyalgiaand40selfreportedsymptomsandcomorbidities AT ashleyadarakjian highoverlapinpatientsdiagnosedwithhypermobileehlersdanlossyndromeorhypermobilespectrumdisorderswithfibromyalgiaand40selfreportedsymptomsandcomorbidities AT barbarakbruce highoverlapinpatientsdiagnosedwithhypermobileehlersdanlossyndromeorhypermobilespectrumdisorderswithfibromyalgiaand40selfreportedsymptomsandcomorbidities AT jessicamgehin highoverlapinpatientsdiagnosedwithhypermobileehlersdanlossyndromeorhypermobilespectrumdisorderswithfibromyalgiaand40selfreportedsymptomsandcomorbidities AT archanakotha highoverlapinpatientsdiagnosedwithhypermobileehlersdanlossyndromeorhypermobilespectrumdisorderswithfibromyalgiaand40selfreportedsymptomsandcomorbidities AT angitajain highoverlapinpatientsdiagnosedwithhypermobileehlersdanlossyndromeorhypermobilespectrumdisorderswithfibromyalgiaand40selfreportedsymptomsandcomorbidities AT zhongweipeng highoverlapinpatientsdiagnosedwithhypermobileehlersdanlossyndromeorhypermobilespectrumdisorderswithfibromyalgiaand40selfreportedsymptomsandcomorbidities AT davidohodge highoverlapinpatientsdiagnosedwithhypermobileehlersdanlossyndromeorhypermobilespectrumdisorderswithfibromyalgiaand40selfreportedsymptomsandcomorbidities AT todddrozen highoverlapinpatientsdiagnosedwithhypermobileehlersdanlossyndromeorhypermobilespectrumdisorderswithfibromyalgiaand40selfreportedsymptomsandcomorbidities AT balamunipalli highoverlapinpatientsdiagnosedwithhypermobileehlersdanlossyndromeorhypermobilespectrumdisorderswithfibromyalgiaand40selfreportedsymptomsandcomorbidities AT fernandoarivera highoverlapinpatientsdiagnosedwithhypermobileehlersdanlossyndromeorhypermobilespectrumdisorderswithfibromyalgiaand40selfreportedsymptomsandcomorbidities AT pedroamalavet highoverlapinpatientsdiagnosedwithhypermobileehlersdanlossyndromeorhypermobilespectrumdisorderswithfibromyalgiaand40selfreportedsymptomsandcomorbidities AT dacrertknight highoverlapinpatientsdiagnosedwithhypermobileehlersdanlossyndromeorhypermobilespectrumdisorderswithfibromyalgiaand40selfreportedsymptomsandcomorbidities |