Gold Nanoparticles Downregulate IL-6 Expression/Production by Upregulating microRNA-26a-5p and Deactivating the RelA and NF-κBp50 Transcription Pathways in Activated Breast Cancer Cells

Gold Nanoparticles Downregulate IL-6 Expression/Production by Upregulating microRNA-26a-5p and Deactivating the RelA and NF-κBp50 Transcription Pathways in Activated Breast Cancer Cells

MicroRNAs (miRNAs) are involved in the modulation of pathogenic genes by binding to their mRNA sequences’ 3′ untranslated regions (3′UTR). Interleukin-6 (IL-6) is known to promote cancer progression and treatment resistance. In this study, we aimed to explore the therapeutic effects of gold nanopart...

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Bibliographic Details
Main Authors: Aisha Farhana, Abdullah Alsrhani, Ruqaih S. Alghsham, Wassila Derafa, Yusuf Saleem Khan, Zafar Rasheed
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
BC
GNP
gold nanoparticles
microRNA
RelA
IL-6
Online Access:https://www.mdpi.com/1422-0067/25/3/1404

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