Recruitment of the left precentral gyrus in reading epilepsy: A multimodal neuroimaging study
Purpose: In a previous study, we investigated a 42-year-old male patient with primary reading epilepsy using continuous video-electroencephalography (EEG). Reading tasks induced left parasagittal spikes with a higher spike frequency when the phonological reading pathway was recruited compared to the...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | Epilepsy and Behavior Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213323216000074 |
| _version_ | 1818148912999956480 |
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| author | Dima Safi Renée Béland Dang Khoa Nguyen Philippe Pouliot Ismail S. Mohamed Phetsamone Vannasing Julie Tremblay Maryse Lassonde Anne Gallagher |
| author_facet | Dima Safi Renée Béland Dang Khoa Nguyen Philippe Pouliot Ismail S. Mohamed Phetsamone Vannasing Julie Tremblay Maryse Lassonde Anne Gallagher |
| author_sort | Dima Safi |
| collection | DOAJ |
| description | Purpose: In a previous study, we investigated a 42-year-old male patient with primary reading epilepsy using continuous video-electroencephalography (EEG). Reading tasks induced left parasagittal spikes with a higher spike frequency when the phonological reading pathway was recruited compared to the lexical one. Here, we seek to localize the epileptogenic focus in the same patient as a function of reading pathway using multimodal neuroimaging.
Methods and results: The participant read irregular words and nonwords presented in a block-design paradigm during magnetoencephalography (MEG), functional near-infrared spectroscopy (fNIRS), and functional magnetic resonance imaging (fMRI) recordings, all combined with EEG. Spike analyses from MEG, fNIRS, and fMRI–EEGs data revealed an epileptic focus in the left precentral gyrus, and spike localization did not differ in lexical and phonological reading.
Conclusion: This study is the first to investigate ictogenesis in reading epilepsy during both lexical and phonological reading while using three different multimodal neuroimaging techniques. The somatosensory and motor control functions of the left precentral gyrus that are congruently involved in lexical as well as phonological reading can explain the identical spike localization in both reading pathways. The concurrence between our findings in this study and those from our previous one supports the role of the left precentral gyrus in phonological output computation as well as seizure activity in a case of reading epilepsy. |
| first_indexed | 2024-12-11T12:58:41Z |
| format | Article |
| id | doaj.art-9a38e9993f0c411e8843ad5b5f6b0cb0 |
| institution | Directory Open Access Journal |
| issn | 2213-3232 |
| language | English |
| last_indexed | 2024-12-11T12:58:41Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Epilepsy and Behavior Case Reports |
| spelling | doaj.art-9a38e9993f0c411e8843ad5b5f6b0cb02022-12-22T01:06:31ZengElsevierEpilepsy and Behavior Case Reports2213-32322016-01-015C192210.1016/j.ebcr.2016.01.003Recruitment of the left precentral gyrus in reading epilepsy: A multimodal neuroimaging studyDima Safi0Renée Béland1Dang Khoa Nguyen2Philippe Pouliot3Ismail S. Mohamed4Phetsamone Vannasing5Julie Tremblay6Maryse Lassonde7Anne Gallagher8Centre de Recherche du CHU Sainte-Justine, Montréal, CanadaEcole d'orthophonie et d'audiologie, Université de Montréal, Montréal, CanadaService de Neurologie, CHUM Notre-Dame, Montréal, CanadaÉcole Polytechnique, Université de Montréal, Montréal, CanadaIWK Health Center, Dalhousie University, Halifax, CanadaCentre de Recherche du CHU Sainte-Justine, Montréal, CanadaCentre de Recherche du CHU Sainte-Justine, Montréal, CanadaCentre de Recherche du CHU Sainte-Justine, Montréal, CanadaCentre de Recherche du CHU Sainte-Justine, Montréal, CanadaPurpose: In a previous study, we investigated a 42-year-old male patient with primary reading epilepsy using continuous video-electroencephalography (EEG). Reading tasks induced left parasagittal spikes with a higher spike frequency when the phonological reading pathway was recruited compared to the lexical one. Here, we seek to localize the epileptogenic focus in the same patient as a function of reading pathway using multimodal neuroimaging. Methods and results: The participant read irregular words and nonwords presented in a block-design paradigm during magnetoencephalography (MEG), functional near-infrared spectroscopy (fNIRS), and functional magnetic resonance imaging (fMRI) recordings, all combined with EEG. Spike analyses from MEG, fNIRS, and fMRI–EEGs data revealed an epileptic focus in the left precentral gyrus, and spike localization did not differ in lexical and phonological reading. Conclusion: This study is the first to investigate ictogenesis in reading epilepsy during both lexical and phonological reading while using three different multimodal neuroimaging techniques. The somatosensory and motor control functions of the left precentral gyrus that are congruently involved in lexical as well as phonological reading can explain the identical spike localization in both reading pathways. The concurrence between our findings in this study and those from our previous one supports the role of the left precentral gyrus in phonological output computation as well as seizure activity in a case of reading epilepsy.http://www.sciencedirect.com/science/article/pii/S2213323216000074Reading epilepsyMultimodal neuroimagingIctogenesisLeft precentral gyrusPhonological readingLexical reading |
| spellingShingle | Dima Safi Renée Béland Dang Khoa Nguyen Philippe Pouliot Ismail S. Mohamed Phetsamone Vannasing Julie Tremblay Maryse Lassonde Anne Gallagher Recruitment of the left precentral gyrus in reading epilepsy: A multimodal neuroimaging study Epilepsy and Behavior Case Reports Reading epilepsy Multimodal neuroimaging Ictogenesis Left precentral gyrus Phonological reading Lexical reading |
| title | Recruitment of the left precentral gyrus in reading epilepsy: A multimodal neuroimaging study |
| title_full | Recruitment of the left precentral gyrus in reading epilepsy: A multimodal neuroimaging study |
| title_fullStr | Recruitment of the left precentral gyrus in reading epilepsy: A multimodal neuroimaging study |
| title_full_unstemmed | Recruitment of the left precentral gyrus in reading epilepsy: A multimodal neuroimaging study |
| title_short | Recruitment of the left precentral gyrus in reading epilepsy: A multimodal neuroimaging study |
| title_sort | recruitment of the left precentral gyrus in reading epilepsy a multimodal neuroimaging study |
| topic | Reading epilepsy Multimodal neuroimaging Ictogenesis Left precentral gyrus Phonological reading Lexical reading |
| url | http://www.sciencedirect.com/science/article/pii/S2213323216000074 |
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