G-Quadruplex DNA and Other Non-Canonical B-Form DNA Motifs Influence Productive and Latent HIV-1 Integration and Reactivation Potential

G-Quadruplex DNA and Other Non-Canonical B-Form DNA Motifs Influence Productive and Latent HIV-1 Integration and Reactivation Potential

The integration of the HIV-1 genome into the host genome is an essential step in the life cycle of the virus and it plays a critical role in the expression, long-term persistence, and reactivation of HIV expression. To better understand the local genomic environment surrounding HIV-1 proviruses, we...

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Bibliographic Details
Main Authors: Hannah O. Ajoge, Hinissan P. Kohio, Ermela Paparisto, Macon D. Coleman, Kemen Wong, Sean K. Tom, Katie L. Bain, Charles C. Berry, Eric J. Arts, Stephen D. Barr
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Viruses
Subjects:
HIV
integration
latency
provirus reactivation
non-B DNA
guanine-quadruplex (G4) DNA
Online Access:https://www.mdpi.com/1999-4915/14/11/2494

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