Hashimoto’s Thyroiditis: A “Double-Edged Sword” in Thyroid Carcinoma
BackgroundThe prevalence of thyroid carcinoma (TC) and Hashimoto’s thyroiditis (HT) has been increasing dramatically over the past decades. We investigated the relationship between HT and TC.MethodsWe followed the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines for carrying...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-02-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.801925/full |
| _version_ | 1819279408836378624 |
|---|---|
| author | Jiangyue Xu Ke Ding Lan Mu Jiangsheng Huang Fei Ye Yu Peng Can Guo Chutong Ren |
| author_facet | Jiangyue Xu Ke Ding Lan Mu Jiangsheng Huang Fei Ye Yu Peng Can Guo Chutong Ren |
| author_sort | Jiangyue Xu |
| collection | DOAJ |
| description | BackgroundThe prevalence of thyroid carcinoma (TC) and Hashimoto’s thyroiditis (HT) has been increasing dramatically over the past decades. We investigated the relationship between HT and TC.MethodsWe followed the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines for carrying out and reporting this meta-analysis. The literature from January 1, 2010 to December 31, 2020, regardless of region and publication type, was searched comprehensively in PubMed, Embase, Web of Science, and Cochrane Library databases. After careful selection and data extraction, the pooled odds ratio of various clinical characteristics in 39 studies were calculated. Publication bias was analyzed using funnel plots.ResultsMeta-analysis of 39 original research articles showed HT to be a risk factor of TC (pooled odds ratio = 1.71; 95% confidence interval, 1.57–1.80; p < 0.00001) and papillary thyroid carcinoma (1.67, 1.51–1.85, <0.00001). Patients with papillary thyroid carcinoma (PTC) combined with HT were more likely to have multifocal carcinomas. The prevalence of an extrathyroidal extension, metastasis, BRAFV600E mutation, and recurrence was significantly lower in patients with PTC combined with HT.ConclusionsHT is a “double-edged sword” in TC patients. HT increases the risk of TC and PTC but is a protective factor against PTC progression. |
| first_indexed | 2024-12-24T00:27:26Z |
| format | Article |
| id | doaj.art-9a3aa21bfdaf449a82e11f661683b2b1 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-24T00:27:26Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-9a3aa21bfdaf449a82e11f661683b2b12022-12-21T17:24:24ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-02-011310.3389/fendo.2022.801925801925Hashimoto’s Thyroiditis: A “Double-Edged Sword” in Thyroid CarcinomaJiangyue Xu0Ke Ding1Lan Mu2Jiangsheng Huang3Fei Ye4Yu Peng5Can Guo6Chutong Ren7Department of General Surgery Thyroid Specialty, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Urology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of General Surgery Thyroid Specialty, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of General Surgery Thyroid Specialty, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of General Surgery Thyroid Specialty, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of General Surgery Thyroid Specialty, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of General Surgery Thyroid Specialty, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of General Surgery Thyroid Specialty, The Second Xiangya Hospital of Central South University, Changsha, ChinaBackgroundThe prevalence of thyroid carcinoma (TC) and Hashimoto’s thyroiditis (HT) has been increasing dramatically over the past decades. We investigated the relationship between HT and TC.MethodsWe followed the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines for carrying out and reporting this meta-analysis. The literature from January 1, 2010 to December 31, 2020, regardless of region and publication type, was searched comprehensively in PubMed, Embase, Web of Science, and Cochrane Library databases. After careful selection and data extraction, the pooled odds ratio of various clinical characteristics in 39 studies were calculated. Publication bias was analyzed using funnel plots.ResultsMeta-analysis of 39 original research articles showed HT to be a risk factor of TC (pooled odds ratio = 1.71; 95% confidence interval, 1.57–1.80; p < 0.00001) and papillary thyroid carcinoma (1.67, 1.51–1.85, <0.00001). Patients with papillary thyroid carcinoma (PTC) combined with HT were more likely to have multifocal carcinomas. The prevalence of an extrathyroidal extension, metastasis, BRAFV600E mutation, and recurrence was significantly lower in patients with PTC combined with HT.ConclusionsHT is a “double-edged sword” in TC patients. HT increases the risk of TC and PTC but is a protective factor against PTC progression.https://www.frontiersin.org/articles/10.3389/fendo.2022.801925/fullHashimoto’s thyroiditis (HT)thyroid carcinoma (TC)meta-analysispapillary thyroid carcinomaBRAFV600E mutation |
| spellingShingle | Jiangyue Xu Ke Ding Lan Mu Jiangsheng Huang Fei Ye Yu Peng Can Guo Chutong Ren Hashimoto’s Thyroiditis: A “Double-Edged Sword” in Thyroid Carcinoma Frontiers in Endocrinology Hashimoto’s thyroiditis (HT) thyroid carcinoma (TC) meta-analysis papillary thyroid carcinoma BRAFV600E mutation |
| title | Hashimoto’s Thyroiditis: A “Double-Edged Sword” in Thyroid Carcinoma |
| title_full | Hashimoto’s Thyroiditis: A “Double-Edged Sword” in Thyroid Carcinoma |
| title_fullStr | Hashimoto’s Thyroiditis: A “Double-Edged Sword” in Thyroid Carcinoma |
| title_full_unstemmed | Hashimoto’s Thyroiditis: A “Double-Edged Sword” in Thyroid Carcinoma |
| title_short | Hashimoto’s Thyroiditis: A “Double-Edged Sword” in Thyroid Carcinoma |
| title_sort | hashimoto s thyroiditis a double edged sword in thyroid carcinoma |
| topic | Hashimoto’s thyroiditis (HT) thyroid carcinoma (TC) meta-analysis papillary thyroid carcinoma BRAFV600E mutation |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.801925/full |
| work_keys_str_mv | AT jiangyuexu hashimotosthyroiditisadoubleedgedswordinthyroidcarcinoma AT keding hashimotosthyroiditisadoubleedgedswordinthyroidcarcinoma AT lanmu hashimotosthyroiditisadoubleedgedswordinthyroidcarcinoma AT jiangshenghuang hashimotosthyroiditisadoubleedgedswordinthyroidcarcinoma AT feiye hashimotosthyroiditisadoubleedgedswordinthyroidcarcinoma AT yupeng hashimotosthyroiditisadoubleedgedswordinthyroidcarcinoma AT canguo hashimotosthyroiditisadoubleedgedswordinthyroidcarcinoma AT chutongren hashimotosthyroiditisadoubleedgedswordinthyroidcarcinoma |