Grape seed extract alleviates radiation-induced damages in human blood lymphocytes
<strong>Objective:</strong> Ionizing radiation induces deleterious effects in the biological systems by producing free radicals. Grape Seed Extract (GSE) as a free radical scavenger could protect the body against the damages<em>.</em><br /> <strong>Materials and M...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2020-07-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | http://ajp.mums.ac.ir/article_14575_ed316c580e17fb1bb6365dde0d121d34.pdf |
| Summary: | <strong>Objective:</strong> Ionizing radiation induces deleterious effects in the biological systems by producing free radicals. Grape Seed Extract (GSE) as a free radical scavenger could protect the body against the damages<em>.</em><br /> <strong>Materials and Methods:</strong> In this study, 12 healthy male volunteers were divided into Groups 1, 2, 3 and 4 and received 100, 300, 600 and 1000 mg GSE, respectively. Peripheral blood samples were collected from each volunteer 15 min before, and 1, 2, and 5 hr after GSE oral administration. Blood samples were then irradiated with 150 cGy of 100 kvp X-ray (Irradiated control group, was treated with only 1.5 Gy of X-rays). Cytogenic damages were detected by micronucleus assay.<br /> <strong>Results:</strong> Results showed that irradiation significantly increased the incidence of micronuclei (p <strong>Conclusion:</strong> Consumption of GSE before undergoing radiation protects human lymphocytes against X-rays by reducing radiation-induced genotoxicity. |
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| ISSN: | 2228-7930 2228-7949 |