Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL) on Magnetic Resonance Spectroscopy: A Clinical Observation
Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) on magnetic resonance spectroscopy is a rare and little-known form of hereditary leukoencephalopathy, a significant portion of which is probably obscured by the label of primary progressive multiple sclerosis...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Research Center of Neurology
2020-06-01
|
| Series: | Анналы клинической и экспериментальной неврологии |
| Subjects: | |
| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/665/527 |
| _version_ | 1818230600200355840 |
|---|---|
| author | Alexander Yu. Kazantsev Tatiana V. Matveeva |
| author_facet | Alexander Yu. Kazantsev Tatiana V. Matveeva |
| author_sort | Alexander Yu. Kazantsev |
| collection | DOAJ |
| description | Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) on magnetic resonance spectroscopy is a rare and little-known form of hereditary leukoencephalopathy, a significant portion of which is probably obscured by the label of primary progressive multiple sclerosis. The article presents a clinical case of an adult form of LBSL and a review of the literature on this disease, discusses the particular pyramidal syndrome lesions in LBSL and multiple sclerosis, and presents the MRI criteria for LBSL. The difficulty in differential diagnosis with Krabbe disease is highlighted. Clinical observation confirms the difficulty of diagnosing LBSL and the lack of medical awareness about this disease. |
| first_indexed | 2024-12-12T10:37:04Z |
| format | Article |
| id | doaj.art-9a3b592f0f444628ae50b808eb5be48d |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-12-12T10:37:04Z |
| publishDate | 2020-06-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-9a3b592f0f444628ae50b808eb5be48d2022-12-22T00:27:10ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332020-06-01142939810.25692/ACEN.2020.2.13504Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL) on Magnetic Resonance Spectroscopy: A Clinical ObservationAlexander Yu. Kazantsev0Tatiana V. Matveeva1Kazan State Medical UniversityKazan State Medical UniversityLeukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) on magnetic resonance spectroscopy is a rare and little-known form of hereditary leukoencephalopathy, a significant portion of which is probably obscured by the label of primary progressive multiple sclerosis. The article presents a clinical case of an adult form of LBSL and a review of the literature on this disease, discusses the particular pyramidal syndrome lesions in LBSL and multiple sclerosis, and presents the MRI criteria for LBSL. The difficulty in differential diagnosis with Krabbe disease is highlighted. Clinical observation confirms the difficulty of diagnosing LBSL and the lack of medical awareness about this disease.https://annaly-nevrologii.com/journal/pathID/article/viewFile/665/527leukoencephalopathyhereditary leukoencephalopathylbsldars2spastic paraplegia of the lower limbs |
| spellingShingle | Alexander Yu. Kazantsev Tatiana V. Matveeva Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL) on Magnetic Resonance Spectroscopy: A Clinical Observation Анналы клинической и экспериментальной неврологии leukoencephalopathy hereditary leukoencephalopathy lbsl dars2 spastic paraplegia of the lower limbs |
| title | Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL) on Magnetic Resonance Spectroscopy: A Clinical Observation |
| title_full | Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL) on Magnetic Resonance Spectroscopy: A Clinical Observation |
| title_fullStr | Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL) on Magnetic Resonance Spectroscopy: A Clinical Observation |
| title_full_unstemmed | Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL) on Magnetic Resonance Spectroscopy: A Clinical Observation |
| title_short | Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation (LBSL) on Magnetic Resonance Spectroscopy: A Clinical Observation |
| title_sort | leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation lbsl on magnetic resonance spectroscopy a clinical observation |
| topic | leukoencephalopathy hereditary leukoencephalopathy lbsl dars2 spastic paraplegia of the lower limbs |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/665/527 |
| work_keys_str_mv | AT alexanderyukazantsev leukoencephalopathywithbrainstemandspinalcordinvolvementandlactateelevationlbslonmagneticresonancespectroscopyaclinicalobservation AT tatianavmatveeva leukoencephalopathywithbrainstemandspinalcordinvolvementandlactateelevationlbslonmagneticresonancespectroscopyaclinicalobservation |