Advances in corneal stromal regeneration and repair
Corneal stroma is a significant part of the cornea and plays a significant role in the eye's refractive system. Although corneal transplantation is now the most effective treatment for corneal stromal disease, its advancement has been constrained by a shortage of donors, the need for prolonged...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2024-03-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2024/3/202403010.pdf |
| _version_ | 1797293947680194560 |
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| author | Zheng Tianshuo Shi Xuejing Xin Meng |
| author_facet | Zheng Tianshuo Shi Xuejing Xin Meng |
| author_sort | Zheng Tianshuo |
| collection | DOAJ |
| description | Corneal stroma is a significant part of the cornea and plays a significant role in the eye's refractive system. Although corneal transplantation is now the most effective treatment for corneal stromal disease, its advancement has been constrained by a shortage of donors, the need for prolonged immunosuppressive medicine to prevent rejection, and low graft survival rates. An alternate strategy is to use the corneal stroma's natural capacity for regeneration to create the ideal conditions for the collagenous extracellular matrix of the stroma to self-renew. However, it is challenging to replicate the intricate ultrastructure of the corneal stroma in vitro. Regenerative medicine has so been used to address these issues. These approaches refer to numerous disciplines, including stem cell-induced differentiation, tissue engineering and gene editing. This article provides potential directions for the future clinical applications of corneal stromal regeneration and repair while summarizing pertinent techniques, research progress, and issues. |
| first_indexed | 2024-03-07T21:22:10Z |
| format | Article |
| id | doaj.art-9a3b617c0d4e4007b301c8fe7b63d63f |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-03-07T21:22:10Z |
| publishDate | 2024-03-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-9a3b617c0d4e4007b301c8fe7b63d63f2024-02-27T08:53:25ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232024-03-0124338438810.3980/j.issn.1672-5123.2024.3.10202403010Advances in corneal stromal regeneration and repairZheng Tianshuo0Shi Xuejing1Xin Meng2Department of Ophthalmology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264199, Shandong Province, ChinaDepartment of Ophthalmology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264199, Shandong Province, ChinaDepartment of Ophthalmology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264199, Shandong Province, ChinaCorneal stroma is a significant part of the cornea and plays a significant role in the eye's refractive system. Although corneal transplantation is now the most effective treatment for corneal stromal disease, its advancement has been constrained by a shortage of donors, the need for prolonged immunosuppressive medicine to prevent rejection, and low graft survival rates. An alternate strategy is to use the corneal stroma's natural capacity for regeneration to create the ideal conditions for the collagenous extracellular matrix of the stroma to self-renew. However, it is challenging to replicate the intricate ultrastructure of the corneal stroma in vitro. Regenerative medicine has so been used to address these issues. These approaches refer to numerous disciplines, including stem cell-induced differentiation, tissue engineering and gene editing. This article provides potential directions for the future clinical applications of corneal stromal regeneration and repair while summarizing pertinent techniques, research progress, and issues.http://ies.ijo.cn/cn_publish/2024/3/202403010.pdfcorneacorneal stromaregenerative medicinecell therapytissue engineeringgene editing |
| spellingShingle | Zheng Tianshuo Shi Xuejing Xin Meng Advances in corneal stromal regeneration and repair Guoji Yanke Zazhi cornea corneal stroma regenerative medicine cell therapy tissue engineering gene editing |
| title | Advances in corneal stromal regeneration and repair |
| title_full | Advances in corneal stromal regeneration and repair |
| title_fullStr | Advances in corneal stromal regeneration and repair |
| title_full_unstemmed | Advances in corneal stromal regeneration and repair |
| title_short | Advances in corneal stromal regeneration and repair |
| title_sort | advances in corneal stromal regeneration and repair |
| topic | cornea corneal stroma regenerative medicine cell therapy tissue engineering gene editing |
| url | http://ies.ijo.cn/cn_publish/2024/3/202403010.pdf |
| work_keys_str_mv | AT zhengtianshuo advancesincornealstromalregenerationandrepair AT shixuejing advancesincornealstromalregenerationandrepair AT xinmeng advancesincornealstromalregenerationandrepair |