Designing target trials using electronic health records: A case study of second-line disease-modifying anti-rheumatic drugs and cardiovascular disease outcomes in patients with rheumatoid arthritis.

Designing target trials using electronic health records: A case study of second-line disease-modifying anti-rheumatic drugs and cardiovascular disease outcomes in patients with rheumatoid arthritis.

<h4>Background</h4>Emulation of the "target trial" (TT), a hypothetical pragmatic randomized controlled trial (RCT), using observational data can be used to mitigate issues commonly encountered in comparative effectiveness research (CER) when randomized trials are not logistica...

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Bibliographic Details
Main Authors: Adovich S Rivera, Jacob B Pierce, Arjun Sinha, Anna E Pawlowski, Donald M Lloyd-Jones, Yvonne C Lee, Matthew J Feinstein, Lucia C Petito
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0305467

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https://doi.org/10.1371/journal.pone.0305467

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