The Ability of the Nitric Oxide Synthases Inhibitor T1023 to Selectively Protect the Non-Malignant Tissues

The Ability of the Nitric Oxide Synthases Inhibitor T1023 to Selectively Protect the Non-Malignant Tissues

Previously, we showed that a nitric oxide synthase (NOS) inhibitor, compound T1023, induces transient hypoxia and prevents acute radiation syndrome (ARS) in mice. Significant efficacy (according to various tests, dose modifying factor (DMF)—1.6–1.9 against H-ARS/G-ARS) and safety in radioprotective...

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Bibliographic Details
Main Authors: Marina Filimonova, Alina Saburova, Victoria Makarchuk, Ljudmila Shevchenko, Valentina Surinova, Vadim Yuzhakov, Nina Yakovleva, Larisa Sevankaeva, Vyacheslav Saburov, Sergey Koryakin, Petr Shegay, Andrey Kaprin, Sergey Ivanov, Alexander Filimonov
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
nitric oxide synthase inhibitor
radiotherapy
radiation-induced tissue toxicity
selective radiation protection
Online Access:https://www.mdpi.com/1422-0067/22/17/9340

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