Combination of C-reactive protein/albumin ratio and time to castration resistance enhances prediction of prognosis for patients with metastatic castration-resistant prostate cancer
ObjectiveThis study aimed to identify the prediction accuracy of the combination of C-reactive protein (CRP) albumin ratio (CAR) and time to castration resistance (TTCR) for overall survival (OS) following development of metastatic castration-resistant prostate cancer (mCRPC).MethodsClinical data fr...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-06-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1162820/full |
| _version_ | 1797813742638989312 |
|---|---|
| author | Yozo Mitsui Fumito Yamabe Shunsuke Hori Masato Uetani Hiroshi Aoki Kei Sakurabayashi Mizuho Okawa Hideyuki Kobayashi Koichi Nagao Koichi Nakajima |
| author_facet | Yozo Mitsui Fumito Yamabe Shunsuke Hori Masato Uetani Hiroshi Aoki Kei Sakurabayashi Mizuho Okawa Hideyuki Kobayashi Koichi Nagao Koichi Nakajima |
| author_sort | Yozo Mitsui |
| collection | DOAJ |
| description | ObjectiveThis study aimed to identify the prediction accuracy of the combination of C-reactive protein (CRP) albumin ratio (CAR) and time to castration resistance (TTCR) for overall survival (OS) following development of metastatic castration-resistant prostate cancer (mCRPC).MethodsClinical data from 98 mCRPC patients treated at our institution from 2009 to 2021 were retrospectively evaluated. Optimal cutoff values for CAR and TTCR to predict lethality were generated by use of a receiver operating curve and Youden’s index. The Kaplan–Meier method and Cox proportional hazard regression models for OS were used to analyze the prognostic capabilities of CAR and TTCR. Multiple multivariate Cox models were then constructed based on univariate analysis and their accuracy was validated using the concordance index.ResultsThe optimal cutoff values for CAR at the time of mCRPC diagnosis and TTCR were 0.48 and 12 months, respectively. Kaplan–Meier curves indicated that patients with CAR >0.48 or TTCR <12 months had a significantly worse OS (both p < 0.005). Univariate analysis also identified age, hemoglobin, CRP, and performance status as candidate prognostic factors. Furthermore, a multivariate analysis model incorporating those factors and excluding CRP showed CAR and TTCR to be independent prognostic factors. This model had better prognostic accuracy as compared with that containing CRP instead of CAR. The results showed effective stratification of mCRPC patients in terms of OS based on CAR and TTCR (p < 0.0001).ConclusionAlthough further investigation is required, CAR and TTCR used in combination may more accurately predict mCRPC patient prognosis. |
| first_indexed | 2024-03-13T07:56:18Z |
| format | Article |
| id | doaj.art-9a417e6952394e9f97ccce665495c7c3 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T07:56:18Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-9a417e6952394e9f97ccce665495c7c32023-06-02T04:26:16ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-06-011310.3389/fonc.2023.11628201162820Combination of C-reactive protein/albumin ratio and time to castration resistance enhances prediction of prognosis for patients with metastatic castration-resistant prostate cancerYozo MitsuiFumito YamabeShunsuke HoriMasato UetaniHiroshi AokiKei SakurabayashiMizuho OkawaHideyuki KobayashiKoichi NagaoKoichi NakajimaObjectiveThis study aimed to identify the prediction accuracy of the combination of C-reactive protein (CRP) albumin ratio (CAR) and time to castration resistance (TTCR) for overall survival (OS) following development of metastatic castration-resistant prostate cancer (mCRPC).MethodsClinical data from 98 mCRPC patients treated at our institution from 2009 to 2021 were retrospectively evaluated. Optimal cutoff values for CAR and TTCR to predict lethality were generated by use of a receiver operating curve and Youden’s index. The Kaplan–Meier method and Cox proportional hazard regression models for OS were used to analyze the prognostic capabilities of CAR and TTCR. Multiple multivariate Cox models were then constructed based on univariate analysis and their accuracy was validated using the concordance index.ResultsThe optimal cutoff values for CAR at the time of mCRPC diagnosis and TTCR were 0.48 and 12 months, respectively. Kaplan–Meier curves indicated that patients with CAR >0.48 or TTCR <12 months had a significantly worse OS (both p < 0.005). Univariate analysis also identified age, hemoglobin, CRP, and performance status as candidate prognostic factors. Furthermore, a multivariate analysis model incorporating those factors and excluding CRP showed CAR and TTCR to be independent prognostic factors. This model had better prognostic accuracy as compared with that containing CRP instead of CAR. The results showed effective stratification of mCRPC patients in terms of OS based on CAR and TTCR (p < 0.0001).ConclusionAlthough further investigation is required, CAR and TTCR used in combination may more accurately predict mCRPC patient prognosis.https://www.frontiersin.org/articles/10.3389/fonc.2023.1162820/fullC-reactive protein albumin ratiotime to castration resistancemetastatic castration-resistant prostate cancer (mCRPC)metastatic hormone sensitive prostate cancerbiomarker |
| spellingShingle | Yozo Mitsui Fumito Yamabe Shunsuke Hori Masato Uetani Hiroshi Aoki Kei Sakurabayashi Mizuho Okawa Hideyuki Kobayashi Koichi Nagao Koichi Nakajima Combination of C-reactive protein/albumin ratio and time to castration resistance enhances prediction of prognosis for patients with metastatic castration-resistant prostate cancer Frontiers in Oncology C-reactive protein albumin ratio time to castration resistance metastatic castration-resistant prostate cancer (mCRPC) metastatic hormone sensitive prostate cancer biomarker |
| title | Combination of C-reactive protein/albumin ratio and time to castration resistance enhances prediction of prognosis for patients with metastatic castration-resistant prostate cancer |
| title_full | Combination of C-reactive protein/albumin ratio and time to castration resistance enhances prediction of prognosis for patients with metastatic castration-resistant prostate cancer |
| title_fullStr | Combination of C-reactive protein/albumin ratio and time to castration resistance enhances prediction of prognosis for patients with metastatic castration-resistant prostate cancer |
| title_full_unstemmed | Combination of C-reactive protein/albumin ratio and time to castration resistance enhances prediction of prognosis for patients with metastatic castration-resistant prostate cancer |
| title_short | Combination of C-reactive protein/albumin ratio and time to castration resistance enhances prediction of prognosis for patients with metastatic castration-resistant prostate cancer |
| title_sort | combination of c reactive protein albumin ratio and time to castration resistance enhances prediction of prognosis for patients with metastatic castration resistant prostate cancer |
| topic | C-reactive protein albumin ratio time to castration resistance metastatic castration-resistant prostate cancer (mCRPC) metastatic hormone sensitive prostate cancer biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1162820/full |
| work_keys_str_mv | AT yozomitsui combinationofcreactiveproteinalbuminratioandtimetocastrationresistanceenhancespredictionofprognosisforpatientswithmetastaticcastrationresistantprostatecancer AT fumitoyamabe combinationofcreactiveproteinalbuminratioandtimetocastrationresistanceenhancespredictionofprognosisforpatientswithmetastaticcastrationresistantprostatecancer AT shunsukehori combinationofcreactiveproteinalbuminratioandtimetocastrationresistanceenhancespredictionofprognosisforpatientswithmetastaticcastrationresistantprostatecancer AT masatouetani combinationofcreactiveproteinalbuminratioandtimetocastrationresistanceenhancespredictionofprognosisforpatientswithmetastaticcastrationresistantprostatecancer AT hiroshiaoki combinationofcreactiveproteinalbuminratioandtimetocastrationresistanceenhancespredictionofprognosisforpatientswithmetastaticcastrationresistantprostatecancer AT keisakurabayashi combinationofcreactiveproteinalbuminratioandtimetocastrationresistanceenhancespredictionofprognosisforpatientswithmetastaticcastrationresistantprostatecancer AT mizuhookawa combinationofcreactiveproteinalbuminratioandtimetocastrationresistanceenhancespredictionofprognosisforpatientswithmetastaticcastrationresistantprostatecancer AT hideyukikobayashi combinationofcreactiveproteinalbuminratioandtimetocastrationresistanceenhancespredictionofprognosisforpatientswithmetastaticcastrationresistantprostatecancer AT koichinagao combinationofcreactiveproteinalbuminratioandtimetocastrationresistanceenhancespredictionofprognosisforpatientswithmetastaticcastrationresistantprostatecancer AT koichinakajima combinationofcreactiveproteinalbuminratioandtimetocastrationresistanceenhancespredictionofprognosisforpatientswithmetastaticcastrationresistantprostatecancer |