Epigenetic Regulatory Mechanisms Associated with Infertility
Infertility is a complex human condition and is known to be caused by numerous factors including genetic alterations and abnormalities. Increasing evidence from studies has associated perturbed epigenetic mechanisms with spermatogenesis and infertility. However, there has been no consensus on whet...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2010-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2010/198709 |
| _version_ | 1798043379897991168 |
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| author | Sheroy Minocherhomji Prochi F. Madon Firuza R. Parikh |
| author_facet | Sheroy Minocherhomji Prochi F. Madon Firuza R. Parikh |
| author_sort | Sheroy Minocherhomji |
| collection | DOAJ |
| description | Infertility is a complex human condition and is known to be caused by numerous factors including genetic alterations and abnormalities. Increasing evidence from studies has associated perturbed epigenetic mechanisms with spermatogenesis and infertility. However, there has been no consensus on whether one or a collective of these altered states is responsible for the onset of infertility. Epigenetic alterations involve changes in factors that regulate gene expression without altering the physical sequence of DNA. Understanding these altered epigenetic states at the genomic level along with higher order organisation of chromatin in genes associated with infertility and pericentromeric regions of chromosomes, particularly 9 and Y, could further identify causes of idiopathic infertility. Determining the association between DNA methylation, chromatin state, and noncoding RNAs with the phenotype could further determine what possible mechanisms are involved. This paper reviews certain mechanisms of epigenetic regulation with particular emphasis on their possible role in infertility. |
| first_indexed | 2024-04-11T22:48:15Z |
| format | Article |
| id | doaj.art-9a422b95eb7a4cd4aca0c5b6dd4e68d7 |
| institution | Directory Open Access Journal |
| issn | 1687-9589 1687-9597 |
| language | English |
| last_indexed | 2024-04-11T22:48:15Z |
| publishDate | 2010-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj.art-9a422b95eb7a4cd4aca0c5b6dd4e68d72022-12-22T03:58:42ZengHindawi LimitedObstetrics and Gynecology International1687-95891687-95972010-01-01201010.1155/2010/198709198709Epigenetic Regulatory Mechanisms Associated with InfertilitySheroy Minocherhomji0Prochi F. Madon1Firuza R. Parikh2Department of Cellular and Molecular Medicine, Wilhelm Johannsen Centre for Functional Genome Research, Faculty of Health Sciences, Blegdamsvej 3B, University of Copenhagen, 2200 N, Copenhagen, DenmarkDepartment of Assisted Reproduction and Genetics, Jaslok Hospital and Research Centre 15, Dr. G Deshmukh Marg, Mumbai 400 026, IndiaDepartment of Assisted Reproduction and Genetics, Jaslok Hospital and Research Centre 15, Dr. G Deshmukh Marg, Mumbai 400 026, IndiaInfertility is a complex human condition and is known to be caused by numerous factors including genetic alterations and abnormalities. Increasing evidence from studies has associated perturbed epigenetic mechanisms with spermatogenesis and infertility. However, there has been no consensus on whether one or a collective of these altered states is responsible for the onset of infertility. Epigenetic alterations involve changes in factors that regulate gene expression without altering the physical sequence of DNA. Understanding these altered epigenetic states at the genomic level along with higher order organisation of chromatin in genes associated with infertility and pericentromeric regions of chromosomes, particularly 9 and Y, could further identify causes of idiopathic infertility. Determining the association between DNA methylation, chromatin state, and noncoding RNAs with the phenotype could further determine what possible mechanisms are involved. This paper reviews certain mechanisms of epigenetic regulation with particular emphasis on their possible role in infertility.http://dx.doi.org/10.1155/2010/198709 |
| spellingShingle | Sheroy Minocherhomji Prochi F. Madon Firuza R. Parikh Epigenetic Regulatory Mechanisms Associated with Infertility Obstetrics and Gynecology International |
| title | Epigenetic Regulatory Mechanisms Associated with Infertility |
| title_full | Epigenetic Regulatory Mechanisms Associated with Infertility |
| title_fullStr | Epigenetic Regulatory Mechanisms Associated with Infertility |
| title_full_unstemmed | Epigenetic Regulatory Mechanisms Associated with Infertility |
| title_short | Epigenetic Regulatory Mechanisms Associated with Infertility |
| title_sort | epigenetic regulatory mechanisms associated with infertility |
| url | http://dx.doi.org/10.1155/2010/198709 |
| work_keys_str_mv | AT sheroyminocherhomji epigeneticregulatorymechanismsassociatedwithinfertility AT prochifmadon epigeneticregulatorymechanismsassociatedwithinfertility AT firuzarparikh epigeneticregulatorymechanismsassociatedwithinfertility |