Inhibition of Tumor Growth, Angiogenesis, and Microcirculation by the Novel Flk-1 Inhibitor SU5416 as Assessed by Intravital Multi-fluorescence Videomicroscopy
Vascular endothelial growth factor (VEGF) plays a fundamental role in mediating tumor angiogenesis and tumor growth. Here we investigate the direct effect of a novel small molecule inhibitor of the Flk-1-mediated signal transduction pathway of VEGF, SU5416, on tumor angiogenesis and microhemodynamic...
Main Authors: | Peter Vajkoczy, Michael D. Menger, Brigitte Vollmar, Lothar Schilling, Peter Schmiedek, K. Peter Hirth, Axel Ullrich, T.Annie T. Fong |
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Format: | Article |
Language: | English |
Published: |
Elsevier
1999-04-01
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Series: | Neoplasia: An International Journal for Oncology Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558699800335 |
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