A cross-sectional study of symptoms and health-related quality of life in menopausal-aged women in China
Abstract Objective To measure symptoms and health-related quality of life in a cross-sectional cohort of menopausal-aged women in China. Method A cross-sectional survey was conducted in a general population cohort of 2,000 Chinese females over the age of 45 years. Patients completed the Chinese vers...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Women's Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12905-023-02728-y |
| _version_ | 1797636697158057984 |
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| author | Tamlyn A. Rautenberg Shu Kay Angus Ng Martin Downes |
| author_facet | Tamlyn A. Rautenberg Shu Kay Angus Ng Martin Downes |
| author_sort | Tamlyn A. Rautenberg |
| collection | DOAJ |
| description | Abstract Objective To measure symptoms and health-related quality of life in a cross-sectional cohort of menopausal-aged women in China. Method A cross-sectional survey was conducted in a general population cohort of 2,000 Chinese females over the age of 45 years. Patients completed the Chinese version of the EuroQol-5D five level (EQ5D5L) health-related quality of life instrument via Personal Digital Assistant. Raw scores were converted to utility tariffs using value sets for China. Statistical analysis included Pearson’s chi-square test, z test for multiple comparisons with adjustment by the Bonferroni method, independent-sample t-test, ANOVA, and adjustment by the Tukey method for multiple comparison. Results were considered statistically significant when p < 0.05 and the study was reported according to the STROBE recommendations. Results In a cohort of 2000 women, 732 (37%) were premenopausal, 798 (40%) were perimenopausal and 470 (23%) were postmenopausal. Perimenopausal women reported significantly more symptoms (91%) compared to premenopausal (77%) and postmenopausal (81%) women. Health-related quality of life was significantly lower in symptomatic perimenopausal women compared to premenopausal (0.919, p < 0.05) and postmenopausal (0.877, p < 0.05) women. Within each group there was a statistically significant difference between the health-related quality of life of women with symptoms compared to without symptoms. Conclusion The perimenopausal phase of menopause is associated with significantly more symptoms and significantly lower HRQoL compared to premenopausal and postmenopausal phases. |
| first_indexed | 2024-03-11T12:38:51Z |
| format | Article |
| id | doaj.art-9a42763f005a4ac78858ba35a8558229 |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-03-11T12:38:51Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-9a42763f005a4ac78858ba35a85582292023-11-05T12:28:35ZengBMCBMC Women's Health1472-68742023-11-0123111010.1186/s12905-023-02728-yA cross-sectional study of symptoms and health-related quality of life in menopausal-aged women in ChinaTamlyn A. Rautenberg0Shu Kay Angus Ng1Martin Downes2Centre for Applied Health Economics, Griffith UniversityCentre for Applied Health Economics, Griffith UniversityCentre for Applied Health Economics, Griffith UniversityAbstract Objective To measure symptoms and health-related quality of life in a cross-sectional cohort of menopausal-aged women in China. Method A cross-sectional survey was conducted in a general population cohort of 2,000 Chinese females over the age of 45 years. Patients completed the Chinese version of the EuroQol-5D five level (EQ5D5L) health-related quality of life instrument via Personal Digital Assistant. Raw scores were converted to utility tariffs using value sets for China. Statistical analysis included Pearson’s chi-square test, z test for multiple comparisons with adjustment by the Bonferroni method, independent-sample t-test, ANOVA, and adjustment by the Tukey method for multiple comparison. Results were considered statistically significant when p < 0.05 and the study was reported according to the STROBE recommendations. Results In a cohort of 2000 women, 732 (37%) were premenopausal, 798 (40%) were perimenopausal and 470 (23%) were postmenopausal. Perimenopausal women reported significantly more symptoms (91%) compared to premenopausal (77%) and postmenopausal (81%) women. Health-related quality of life was significantly lower in symptomatic perimenopausal women compared to premenopausal (0.919, p < 0.05) and postmenopausal (0.877, p < 0.05) women. Within each group there was a statistically significant difference between the health-related quality of life of women with symptoms compared to without symptoms. Conclusion The perimenopausal phase of menopause is associated with significantly more symptoms and significantly lower HRQoL compared to premenopausal and postmenopausal phases.https://doi.org/10.1186/s12905-023-02728-yHealth state utility valuesPremenopausalPerimenopausePostmenopausalHealth-related quality of lifeUtility |
| spellingShingle | Tamlyn A. Rautenberg Shu Kay Angus Ng Martin Downes A cross-sectional study of symptoms and health-related quality of life in menopausal-aged women in China BMC Women's Health Health state utility values Premenopausal Perimenopause Postmenopausal Health-related quality of life Utility |
| title | A cross-sectional study of symptoms and health-related quality of life in menopausal-aged women in China |
| title_full | A cross-sectional study of symptoms and health-related quality of life in menopausal-aged women in China |
| title_fullStr | A cross-sectional study of symptoms and health-related quality of life in menopausal-aged women in China |
| title_full_unstemmed | A cross-sectional study of symptoms and health-related quality of life in menopausal-aged women in China |
| title_short | A cross-sectional study of symptoms and health-related quality of life in menopausal-aged women in China |
| title_sort | cross sectional study of symptoms and health related quality of life in menopausal aged women in china |
| topic | Health state utility values Premenopausal Perimenopause Postmenopausal Health-related quality of life Utility |
| url | https://doi.org/10.1186/s12905-023-02728-y |
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