Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: challenges and perspectives
Apigenin is a bioflavonoid compound that is widely present in dietary plant foods and possesses biological activities that protect against immune, cardiovascular, and neurodegenerative diseases and cancer. Therefore, apigenin is widely used in food and medicine, and increasing attention has been dra...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1221227/full |
| _version_ | 1797772117209513984 |
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| author | Peng Chen Fuchao Chen ZhiLei Guo Jiexin Lei Benhong Zhou |
| author_facet | Peng Chen Fuchao Chen ZhiLei Guo Jiexin Lei Benhong Zhou |
| author_sort | Peng Chen |
| collection | DOAJ |
| description | Apigenin is a bioflavonoid compound that is widely present in dietary plant foods and possesses biological activities that protect against immune, cardiovascular, and neurodegenerative diseases and cancer. Therefore, apigenin is widely used in food and medicine, and increasing attention has been drawn to developing new delivery systems for apigenin. This review highlights the biological effects, metabolism, stability, and bioactivity of apigenin. In addition, we summarized advancements in the delivery of apigenin, which provides some references for its widespread use in food and medicine. Better stability of apigenin may enhance digestion and absorption and provide health benefits. Constructing delivery systems (such as emulsions, nanostructured lipid carriers, hydrogels, and liposomes) for apigenin is an effective strategy to improve its bioavailability, but more animal and cell experiments are needed to verify these findings. Developing apigenin delivery systems for food commercialization is still challenging, and further research is needed to promote their in-depth development and utilization. |
| first_indexed | 2024-03-12T21:46:30Z |
| format | Article |
| id | doaj.art-9a441cb168824650ae7f3ac82a782801 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-12T21:46:30Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-9a441cb168824650ae7f3ac82a7828012023-07-26T11:15:36ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-07-011010.3389/fnut.2023.12212271221227Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: challenges and perspectivesPeng Chen0Fuchao Chen1ZhiLei Guo2Jiexin Lei3Benhong Zhou4Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Pharmacy, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Pharmacy, Wuhan Fourth Hospital, Wuhan, Hubei, ChinaDepartment of Endocrinology, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaApigenin is a bioflavonoid compound that is widely present in dietary plant foods and possesses biological activities that protect against immune, cardiovascular, and neurodegenerative diseases and cancer. Therefore, apigenin is widely used in food and medicine, and increasing attention has been drawn to developing new delivery systems for apigenin. This review highlights the biological effects, metabolism, stability, and bioactivity of apigenin. In addition, we summarized advancements in the delivery of apigenin, which provides some references for its widespread use in food and medicine. Better stability of apigenin may enhance digestion and absorption and provide health benefits. Constructing delivery systems (such as emulsions, nanostructured lipid carriers, hydrogels, and liposomes) for apigenin is an effective strategy to improve its bioavailability, but more animal and cell experiments are needed to verify these findings. Developing apigenin delivery systems for food commercialization is still challenging, and further research is needed to promote their in-depth development and utilization.https://www.frontiersin.org/articles/10.3389/fnut.2023.1221227/fullapigeninbiological activitybioavailabilitydrug deliverynatural flavonoid |
| spellingShingle | Peng Chen Fuchao Chen ZhiLei Guo Jiexin Lei Benhong Zhou Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: challenges and perspectives Frontiers in Nutrition apigenin biological activity bioavailability drug delivery natural flavonoid |
| title | Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: challenges and perspectives |
| title_full | Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: challenges and perspectives |
| title_fullStr | Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: challenges and perspectives |
| title_full_unstemmed | Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: challenges and perspectives |
| title_short | Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: challenges and perspectives |
| title_sort | recent advancement in bioeffect metabolism stability and delivery systems of apigenin a natural flavonoid compound challenges and perspectives |
| topic | apigenin biological activity bioavailability drug delivery natural flavonoid |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1221227/full |
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