Marital Status and Prognostic Nomogram for Bladder Cancer With Distant Metastasis: A SEER-Based Study
BackgroundTo investigate the impact of marital status on overall survival (OS) and create a prognostic nomogram predicting OS in distant-metastatic bladder cancer (DMBC) patients.MethodsThe Surveillance, Epidemiology, and End Results (SEER) database was explored to recruit DMBC patients from 2010 to...
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| Format: | Article |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.586458/full |
| _version_ | 1818239551592726528 |
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| author | Liangjun Tao Xinyuan Pan Lixiang Zhang Jiawei Wang Zican Zhang Li Zhang Chaozhao Liang |
| author_facet | Liangjun Tao Xinyuan Pan Lixiang Zhang Jiawei Wang Zican Zhang Li Zhang Chaozhao Liang |
| author_sort | Liangjun Tao |
| collection | DOAJ |
| description | BackgroundTo investigate the impact of marital status on overall survival (OS) and create a prognostic nomogram predicting OS in distant-metastatic bladder cancer (DMBC) patients.MethodsThe Surveillance, Epidemiology, and End Results (SEER) database was explored to recruit DMBC patients from 2010 to 2015. Kaplan–Meier survival analysis was used to compare survival differences among different marital status. Univariate and multivariate analyses were used to screen for prognostic factors and then constructed the nomogram based on Cox proportional hazard regression models. Calibration plot diagrams and concordance index (C-index) were used to verify the prognostic nomogram.ResultsKaplan–Meier curves suggested the significant differences of OS among different marital status existed in total (P < 0.001), female (P = 0.011) and male (P = 0.001) DMBC patients, respectively. Multivariate analysis indicated marital status was an independent prognostic factor for OS of DMBC patients. Nomogram showed the contribution of marital status to predicting OS was small. Other independent prognostic factors included age, grade, histology type, surgery of primary site, chemotherapy, and metastasis pattern. By combining seven factors, we constructed a prognostic nomogram for DMBC patients. The C-index of this nomogram for OS prediction was 0.722 (95% CI 0.712–0.732). The calibration curves showed perfect consistency between observed and predictive survival.ConclusionsMarital status was an independent prognostic factor for OS of DMBC patients, but its contribution to predicting OS was small. The prognostic nomogram will provide an individualized evaluation of OS and guidance for suitable treatments in DMBC patients. |
| first_indexed | 2024-12-12T12:59:21Z |
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| id | doaj.art-9a464aa3aebe4633856a9bad1314882a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T12:59:21Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-9a464aa3aebe4633856a9bad1314882a2022-12-22T00:23:49ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-10-011010.3389/fonc.2020.586458586458Marital Status and Prognostic Nomogram for Bladder Cancer With Distant Metastasis: A SEER-Based StudyLiangjun Tao0Xinyuan Pan1Lixiang Zhang2Jiawei Wang3Zican Zhang4Li Zhang5Chaozhao Liang6Department of Urology, The First Affiliated Hospital of Anhui Medical University, Institute of Urology and Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, ChinaDepartment of Ophthalmology, The Second People's Hospital of Wuhu, Wuhu, ChinaDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Urology, The Second People's Hospital of Wuhu, Wuhu, ChinaClinical College of Bengbu Medical University, Bengbu, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Institute of Urology and Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Institute of Urology and Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, ChinaBackgroundTo investigate the impact of marital status on overall survival (OS) and create a prognostic nomogram predicting OS in distant-metastatic bladder cancer (DMBC) patients.MethodsThe Surveillance, Epidemiology, and End Results (SEER) database was explored to recruit DMBC patients from 2010 to 2015. Kaplan–Meier survival analysis was used to compare survival differences among different marital status. Univariate and multivariate analyses were used to screen for prognostic factors and then constructed the nomogram based on Cox proportional hazard regression models. Calibration plot diagrams and concordance index (C-index) were used to verify the prognostic nomogram.ResultsKaplan–Meier curves suggested the significant differences of OS among different marital status existed in total (P < 0.001), female (P = 0.011) and male (P = 0.001) DMBC patients, respectively. Multivariate analysis indicated marital status was an independent prognostic factor for OS of DMBC patients. Nomogram showed the contribution of marital status to predicting OS was small. Other independent prognostic factors included age, grade, histology type, surgery of primary site, chemotherapy, and metastasis pattern. By combining seven factors, we constructed a prognostic nomogram for DMBC patients. The C-index of this nomogram for OS prediction was 0.722 (95% CI 0.712–0.732). The calibration curves showed perfect consistency between observed and predictive survival.ConclusionsMarital status was an independent prognostic factor for OS of DMBC patients, but its contribution to predicting OS was small. The prognostic nomogram will provide an individualized evaluation of OS and guidance for suitable treatments in DMBC patients.https://www.frontiersin.org/articles/10.3389/fonc.2020.586458/fullbladder cancerdistant metastasismarital statusnomogramprognosis |
| spellingShingle | Liangjun Tao Xinyuan Pan Lixiang Zhang Jiawei Wang Zican Zhang Li Zhang Chaozhao Liang Marital Status and Prognostic Nomogram for Bladder Cancer With Distant Metastasis: A SEER-Based Study Frontiers in Oncology bladder cancer distant metastasis marital status nomogram prognosis |
| title | Marital Status and Prognostic Nomogram for Bladder Cancer With Distant Metastasis: A SEER-Based Study |
| title_full | Marital Status and Prognostic Nomogram for Bladder Cancer With Distant Metastasis: A SEER-Based Study |
| title_fullStr | Marital Status and Prognostic Nomogram for Bladder Cancer With Distant Metastasis: A SEER-Based Study |
| title_full_unstemmed | Marital Status and Prognostic Nomogram for Bladder Cancer With Distant Metastasis: A SEER-Based Study |
| title_short | Marital Status and Prognostic Nomogram for Bladder Cancer With Distant Metastasis: A SEER-Based Study |
| title_sort | marital status and prognostic nomogram for bladder cancer with distant metastasis a seer based study |
| topic | bladder cancer distant metastasis marital status nomogram prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.586458/full |
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