Whole genome comparative studies between chicken and turkey and their implications for avian genome evolution
<p>Abstract</p> <p>Background</p> <p>Comparative genomics is a powerful means of establishing inter-specific relationships between gene function/location and allows insight into genomic rearrangements, conservation and evolutionary phylogeny. The availability of the com...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2008-04-01
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| Series: | BMC Genomics |
| Online Access: | http://www.biomedcentral.com/1471-2164/9/168 |
| _version_ | 1818499332736811008 |
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| author | Carré Wilfrid Gaginskaya Elena Deryusheva Svetlana Groenen Martien AM Crooijmans Richard PMA Fillon Valérie Vignal Alain Tempest Helen G Robertson Lindsay B Griffin Darren K Waddington David Talbot Richard Völker Martin Masabanda Julio S Burt Dave W |
| author_facet | Carré Wilfrid Gaginskaya Elena Deryusheva Svetlana Groenen Martien AM Crooijmans Richard PMA Fillon Valérie Vignal Alain Tempest Helen G Robertson Lindsay B Griffin Darren K Waddington David Talbot Richard Völker Martin Masabanda Julio S Burt Dave W |
| author_sort | Carré Wilfrid |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Comparative genomics is a powerful means of establishing inter-specific relationships between gene function/location and allows insight into genomic rearrangements, conservation and evolutionary phylogeny. The availability of the complete sequence of the chicken genome has initiated the development of detailed genomic information in other birds including turkey, an agriculturally important species where mapping has hitherto focused on linkage with limited physical information. No molecular study has yet examined conservation of avian microchromosomes, nor differences in copy number variants (CNVs) between birds.</p> <p>Results</p> <p>We present a detailed comparative cytogenetic map between chicken and turkey based on reciprocal chromosome painting and mapping of 338 chicken BACs to turkey metaphases. Two inter-chromosomal changes (both involving centromeres) and three pericentric inversions have been identified between chicken and turkey; and array CGH identified 16 inter-specific CNVs.</p> <p>Conclusion</p> <p>This is the first study to combine the modalities of zoo-FISH and array CGH between different avian species. The first insight into the conservation of microchromosomes, the first comparative cytogenetic map of any bird and the first appraisal of CNVs between birds is provided. Results suggest that avian genomes have remained relatively stable during evolution compared to mammalian equivalents.</p> |
| first_indexed | 2024-12-10T20:28:01Z |
| format | Article |
| id | doaj.art-9a47afe582e642d9848e025124abdf3f |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-10T20:28:01Z |
| publishDate | 2008-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-9a47afe582e642d9848e025124abdf3f2022-12-22T01:34:48ZengBMCBMC Genomics1471-21642008-04-019116810.1186/1471-2164-9-168Whole genome comparative studies between chicken and turkey and their implications for avian genome evolutionCarré WilfridGaginskaya ElenaDeryusheva SvetlanaGroenen Martien AMCrooijmans Richard PMAFillon ValérieVignal AlainTempest Helen GRobertson Lindsay BGriffin Darren KWaddington DavidTalbot RichardVölker MartinMasabanda Julio SBurt Dave W<p>Abstract</p> <p>Background</p> <p>Comparative genomics is a powerful means of establishing inter-specific relationships between gene function/location and allows insight into genomic rearrangements, conservation and evolutionary phylogeny. The availability of the complete sequence of the chicken genome has initiated the development of detailed genomic information in other birds including turkey, an agriculturally important species where mapping has hitherto focused on linkage with limited physical information. No molecular study has yet examined conservation of avian microchromosomes, nor differences in copy number variants (CNVs) between birds.</p> <p>Results</p> <p>We present a detailed comparative cytogenetic map between chicken and turkey based on reciprocal chromosome painting and mapping of 338 chicken BACs to turkey metaphases. Two inter-chromosomal changes (both involving centromeres) and three pericentric inversions have been identified between chicken and turkey; and array CGH identified 16 inter-specific CNVs.</p> <p>Conclusion</p> <p>This is the first study to combine the modalities of zoo-FISH and array CGH between different avian species. The first insight into the conservation of microchromosomes, the first comparative cytogenetic map of any bird and the first appraisal of CNVs between birds is provided. Results suggest that avian genomes have remained relatively stable during evolution compared to mammalian equivalents.</p>http://www.biomedcentral.com/1471-2164/9/168 |
| spellingShingle | Carré Wilfrid Gaginskaya Elena Deryusheva Svetlana Groenen Martien AM Crooijmans Richard PMA Fillon Valérie Vignal Alain Tempest Helen G Robertson Lindsay B Griffin Darren K Waddington David Talbot Richard Völker Martin Masabanda Julio S Burt Dave W Whole genome comparative studies between chicken and turkey and their implications for avian genome evolution BMC Genomics |
| title | Whole genome comparative studies between chicken and turkey and their implications for avian genome evolution |
| title_full | Whole genome comparative studies between chicken and turkey and their implications for avian genome evolution |
| title_fullStr | Whole genome comparative studies between chicken and turkey and their implications for avian genome evolution |
| title_full_unstemmed | Whole genome comparative studies between chicken and turkey and their implications for avian genome evolution |
| title_short | Whole genome comparative studies between chicken and turkey and their implications for avian genome evolution |
| title_sort | whole genome comparative studies between chicken and turkey and their implications for avian genome evolution |
| url | http://www.biomedcentral.com/1471-2164/9/168 |
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