A Potential Association between Abdominal Obesity and the Efficacy of Humoral Immunity Induced by COVID-19 and by the AZD1222, Convidecia, BNT162b2, Sputnik V, and CoronaVac Vaccines
Abdominal obesity is highly prevalent in Mexico and has a poor prognosis in terms of the severity of coronavirus disease (COVID-19) and low levels of antibodies induced by infection and vaccination. We evaluated the humoral immune response induced by COVID-19 and five different vaccination schedules...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/12/1/88 |
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| author | Javier Angeles-Martinez Irma Eloisa Monroy-Muñoz José Esteban Muñoz-Medina Larissa Fernandes-Matano Ángel Gustavo Salas-Lais Ma De Los Ángeles Hernández-Cueto Eyerahi Bravo-Flores Moisés León-Juárez Clara Esperanza Santacruz-Tinoco Daniel Montes-Herrera |
| author_facet | Javier Angeles-Martinez Irma Eloisa Monroy-Muñoz José Esteban Muñoz-Medina Larissa Fernandes-Matano Ángel Gustavo Salas-Lais Ma De Los Ángeles Hernández-Cueto Eyerahi Bravo-Flores Moisés León-Juárez Clara Esperanza Santacruz-Tinoco Daniel Montes-Herrera |
| author_sort | Javier Angeles-Martinez |
| collection | DOAJ |
| description | Abdominal obesity is highly prevalent in Mexico and has a poor prognosis in terms of the severity of coronavirus disease (COVID-19) and low levels of antibodies induced by infection and vaccination. We evaluated the humoral immune response induced by COVID-19 and five different vaccination schedules in Mexican individuals with abdominal obesity and the effects of other variables. This prospective longitudinal cohort study included 2084 samples from 389 participants. The levels of anti-S1/S2 and anti-RBD IgG antibodies were measured at various time points after vaccination. A high prevalence of hospitalization and oxygen use was observed in individuals with abdominal obesity (AO) who had COVID-19 before vaccination; however, they also had high levels of anti-S1/S2 and anti-RBD-neutralizing IgG antibodies. The same was true for vaccination-induced antibody levels. However, their longevity was low. Interestingly, we did not observe significant differences in vaccine reactogenicity between abdominally obese and abdominally non-obese groups. Finally, individuals with a higher body mass index, older age, and previous COVID-19 had higher levels of antibodies induced by COVID-19 and vaccination. Therefore, it is important to evaluate other immunological and inflammatory factors to better understand the pathogenesis of COVID-19 in the presence of risk factors and to propose effective vaccination schedules for vulnerable populations. |
| first_indexed | 2024-03-08T09:44:50Z |
| format | Article |
| id | doaj.art-9a49cd4fdfa14a518f2e034583fcdfb0 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-08T09:44:50Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-9a49cd4fdfa14a518f2e034583fcdfb02024-01-29T14:25:59ZengMDPI AGVaccines2076-393X2024-01-011218810.3390/vaccines12010088A Potential Association between Abdominal Obesity and the Efficacy of Humoral Immunity Induced by COVID-19 and by the AZD1222, Convidecia, BNT162b2, Sputnik V, and CoronaVac VaccinesJavier Angeles-Martinez0Irma Eloisa Monroy-Muñoz1José Esteban Muñoz-Medina2Larissa Fernandes-Matano3Ángel Gustavo Salas-Lais4Ma De Los Ángeles Hernández-Cueto5Eyerahi Bravo-Flores6Moisés León-Juárez7Clara Esperanza Santacruz-Tinoco8Daniel Montes-Herrera9Central Epidemiology Laboratory, Mexican Social Security Institute, Mexico City 02990, MexicoReproductive and Perinatal Health Research Department, National Institute of Perinatology, Mexico City 11000, MexicoQuality of Supplies and Specialized Laboratories Coordination, Mexican Social Security Institute, Mexico City 07760, MexicoQuality of Supplies and Specialized Laboratories Coordination, Mexican Social Security Institute, Mexico City 07760, MexicoCentral Epidemiology Laboratory, Mexican Social Security Institute, Mexico City 02990, MexicoCentral Epidemiology Laboratory, Mexican Social Security Institute, Mexico City 02990, MexicoSouthern Medical Line, Mexico City 11000, MexicoImmunobiochemistry Department, National Institute of Perinatology, Mexico City 11000, MexicoSpecialized Laboratories Division, Mexican Social Security Institute, Mexico City 07760, MexicoCentral Epidemiology Laboratory, Mexican Social Security Institute, Mexico City 02990, MexicoAbdominal obesity is highly prevalent in Mexico and has a poor prognosis in terms of the severity of coronavirus disease (COVID-19) and low levels of antibodies induced by infection and vaccination. We evaluated the humoral immune response induced by COVID-19 and five different vaccination schedules in Mexican individuals with abdominal obesity and the effects of other variables. This prospective longitudinal cohort study included 2084 samples from 389 participants. The levels of anti-S1/S2 and anti-RBD IgG antibodies were measured at various time points after vaccination. A high prevalence of hospitalization and oxygen use was observed in individuals with abdominal obesity (AO) who had COVID-19 before vaccination; however, they also had high levels of anti-S1/S2 and anti-RBD-neutralizing IgG antibodies. The same was true for vaccination-induced antibody levels. However, their longevity was low. Interestingly, we did not observe significant differences in vaccine reactogenicity between abdominally obese and abdominally non-obese groups. Finally, individuals with a higher body mass index, older age, and previous COVID-19 had higher levels of antibodies induced by COVID-19 and vaccination. Therefore, it is important to evaluate other immunological and inflammatory factors to better understand the pathogenesis of COVID-19 in the presence of risk factors and to propose effective vaccination schedules for vulnerable populations.https://www.mdpi.com/2076-393X/12/1/88abdominal obesityCOVID-19vaccineshumoral immune response |
| spellingShingle | Javier Angeles-Martinez Irma Eloisa Monroy-Muñoz José Esteban Muñoz-Medina Larissa Fernandes-Matano Ángel Gustavo Salas-Lais Ma De Los Ángeles Hernández-Cueto Eyerahi Bravo-Flores Moisés León-Juárez Clara Esperanza Santacruz-Tinoco Daniel Montes-Herrera A Potential Association between Abdominal Obesity and the Efficacy of Humoral Immunity Induced by COVID-19 and by the AZD1222, Convidecia, BNT162b2, Sputnik V, and CoronaVac Vaccines Vaccines abdominal obesity COVID-19 vaccines humoral immune response |
| title | A Potential Association between Abdominal Obesity and the Efficacy of Humoral Immunity Induced by COVID-19 and by the AZD1222, Convidecia, BNT162b2, Sputnik V, and CoronaVac Vaccines |
| title_full | A Potential Association between Abdominal Obesity and the Efficacy of Humoral Immunity Induced by COVID-19 and by the AZD1222, Convidecia, BNT162b2, Sputnik V, and CoronaVac Vaccines |
| title_fullStr | A Potential Association between Abdominal Obesity and the Efficacy of Humoral Immunity Induced by COVID-19 and by the AZD1222, Convidecia, BNT162b2, Sputnik V, and CoronaVac Vaccines |
| title_full_unstemmed | A Potential Association between Abdominal Obesity and the Efficacy of Humoral Immunity Induced by COVID-19 and by the AZD1222, Convidecia, BNT162b2, Sputnik V, and CoronaVac Vaccines |
| title_short | A Potential Association between Abdominal Obesity and the Efficacy of Humoral Immunity Induced by COVID-19 and by the AZD1222, Convidecia, BNT162b2, Sputnik V, and CoronaVac Vaccines |
| title_sort | potential association between abdominal obesity and the efficacy of humoral immunity induced by covid 19 and by the azd1222 convidecia bnt162b2 sputnik v and coronavac vaccines |
| topic | abdominal obesity COVID-19 vaccines humoral immune response |
| url | https://www.mdpi.com/2076-393X/12/1/88 |
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