Klinefelter Syndrome with Poor Risk Extragonadal Germ Cell Tumor
Germ cell tumors are the most common malignancy in men aged 15-35 years old, with a small percentage presenting in an extragonadal location. These tumors are seldom identified in the gastrointestinal tract. There is increased risk of extragonadal germ cell tumors (EGCT) in men with Klinefelter syndr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | Urology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214442016301127 |
| _version_ | 1830375595849023488 |
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| author | Jeremy A. Konheim Jonathan A. Israel Scott E. Delacroix |
| author_facet | Jeremy A. Konheim Jonathan A. Israel Scott E. Delacroix |
| author_sort | Jeremy A. Konheim |
| collection | DOAJ |
| description | Germ cell tumors are the most common malignancy in men aged 15-35 years old, with a small percentage presenting in an extragonadal location. These tumors are seldom identified in the gastrointestinal tract. There is increased risk of extragonadal germ cell tumors (EGCT) in men with Klinefelter syndrome (KS). We report a rare case of a 37-year-old male with KS and EGCT discovered in the duodenum and pelvis. After treatment with Bleomycin-Etoposide-Cisplatin (BEP), he developed growing teratoma syndrome (GTS) and myelodysplasia. Despite surgical excision of the pelvic growing teratoma, he unfortunately died secondary to complications of severe bone marrow suppression. |
| first_indexed | 2024-12-20T07:57:09Z |
| format | Article |
| id | doaj.art-9a4aadb02b8545b8bdf12d651b3ea46d |
| institution | Directory Open Access Journal |
| issn | 2214-4420 |
| language | English |
| last_indexed | 2024-12-20T07:57:09Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Urology Case Reports |
| spelling | doaj.art-9a4aadb02b8545b8bdf12d651b3ea46d2022-12-21T19:47:38ZengElsevierUrology Case Reports2214-44202017-01-0110C1310.1016/j.eucr.2016.09.006Klinefelter Syndrome with Poor Risk Extragonadal Germ Cell TumorJeremy A. KonheimJonathan A. IsraelScott E. DelacroixGerm cell tumors are the most common malignancy in men aged 15-35 years old, with a small percentage presenting in an extragonadal location. These tumors are seldom identified in the gastrointestinal tract. There is increased risk of extragonadal germ cell tumors (EGCT) in men with Klinefelter syndrome (KS). We report a rare case of a 37-year-old male with KS and EGCT discovered in the duodenum and pelvis. After treatment with Bleomycin-Etoposide-Cisplatin (BEP), he developed growing teratoma syndrome (GTS) and myelodysplasia. Despite surgical excision of the pelvic growing teratoma, he unfortunately died secondary to complications of severe bone marrow suppression.http://www.sciencedirect.com/science/article/pii/S2214442016301127Extragonadal germ cell tumorKlinefelter syndromeGrowing teratoma syndromeMyelodysplasia |
| spellingShingle | Jeremy A. Konheim Jonathan A. Israel Scott E. Delacroix Klinefelter Syndrome with Poor Risk Extragonadal Germ Cell Tumor Urology Case Reports Extragonadal germ cell tumor Klinefelter syndrome Growing teratoma syndrome Myelodysplasia |
| title | Klinefelter Syndrome with Poor Risk Extragonadal Germ Cell Tumor |
| title_full | Klinefelter Syndrome with Poor Risk Extragonadal Germ Cell Tumor |
| title_fullStr | Klinefelter Syndrome with Poor Risk Extragonadal Germ Cell Tumor |
| title_full_unstemmed | Klinefelter Syndrome with Poor Risk Extragonadal Germ Cell Tumor |
| title_short | Klinefelter Syndrome with Poor Risk Extragonadal Germ Cell Tumor |
| title_sort | klinefelter syndrome with poor risk extragonadal germ cell tumor |
| topic | Extragonadal germ cell tumor Klinefelter syndrome Growing teratoma syndrome Myelodysplasia |
| url | http://www.sciencedirect.com/science/article/pii/S2214442016301127 |
| work_keys_str_mv | AT jeremyakonheim klinefeltersyndromewithpoorriskextragonadalgermcelltumor AT jonathanaisrael klinefeltersyndromewithpoorriskextragonadalgermcelltumor AT scottedelacroix klinefeltersyndromewithpoorriskextragonadalgermcelltumor |