Protein Kinases: Potential Drug Targets Against Schistosoma japonicum
Schistosoma japonicum (S. japonicum) infection can induce serious organ damage and cause schistosomiasis japonica which is mainly prevalent in Asia and currently one of the most seriously neglected tropical diseases. Treatment of schistosomiasis largely depends on the drug praziquantel (PZQ). Howeve...
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.691757/full |
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| author | Kaijuan Wu Kaijuan Wu Xingyu Zhai Xingyu Zhai Shuaiqin Huang Liping Jiang Liping Jiang Zheng Yu Zheng Yu Jing Huang Jing Huang |
| author_facet | Kaijuan Wu Kaijuan Wu Xingyu Zhai Xingyu Zhai Shuaiqin Huang Liping Jiang Liping Jiang Zheng Yu Zheng Yu Jing Huang Jing Huang |
| author_sort | Kaijuan Wu |
| collection | DOAJ |
| description | Schistosoma japonicum (S. japonicum) infection can induce serious organ damage and cause schistosomiasis japonica which is mainly prevalent in Asia and currently one of the most seriously neglected tropical diseases. Treatment of schistosomiasis largely depends on the drug praziquantel (PZQ). However, PZQ exhibits low killing efficacy on juvenile worms and the potential emergence of its drug resistance is a continual concern. Protein kinases (PKs) are enzymes that catalyze the phosphorylation of proteins and can participate in many signaling pathways in vivo. Recent studies confirmed the essential roles of PKs in the growth and development of S. japonicum, as well as in schistosome-host interactions, and researches have screened drug targets about PKs from S. japonicum (SjPKs), which provide new opportunities of developing new treatments on schistosomiasis. The aim of this review is to present the current progress on SjPKs from classification, different functions and their potential to become drug targets compared with other schistosomes. The efficiency of related protein kinase inhibitors on schistosomes is highlighted. Finally, the current challenges and problems in the study of SjPKs are proposed, which can provide future guidance for developing anti-schistosomiasis drugs and vaccines. |
| first_indexed | 2024-12-22T13:11:24Z |
| format | Article |
| id | doaj.art-9a4afd9119ef4a3c814732f1556aaed8 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-22T13:11:24Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-9a4afd9119ef4a3c814732f1556aaed82022-12-21T18:24:44ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-07-011110.3389/fcimb.2021.691757691757Protein Kinases: Potential Drug Targets Against Schistosoma japonicumKaijuan Wu0Kaijuan Wu1Xingyu Zhai2Xingyu Zhai3Shuaiqin Huang4Liping Jiang5Liping Jiang6Zheng Yu7Zheng Yu8Jing Huang9Jing Huang10Department of Parasitology, School of Basic Medical Science, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, ChinaDepartment of Parasitology, School of Basic Medical Science, Central South University, Changsha, ChinaDepartment of Parasitology, School of Basic Medical Science, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Microbiology, School of Basic Medical Science, Central South University, Changsha, ChinaDepartment of Parasitology, School of Basic Medical Science, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaSchistosoma japonicum (S. japonicum) infection can induce serious organ damage and cause schistosomiasis japonica which is mainly prevalent in Asia and currently one of the most seriously neglected tropical diseases. Treatment of schistosomiasis largely depends on the drug praziquantel (PZQ). However, PZQ exhibits low killing efficacy on juvenile worms and the potential emergence of its drug resistance is a continual concern. Protein kinases (PKs) are enzymes that catalyze the phosphorylation of proteins and can participate in many signaling pathways in vivo. Recent studies confirmed the essential roles of PKs in the growth and development of S. japonicum, as well as in schistosome-host interactions, and researches have screened drug targets about PKs from S. japonicum (SjPKs), which provide new opportunities of developing new treatments on schistosomiasis. The aim of this review is to present the current progress on SjPKs from classification, different functions and their potential to become drug targets compared with other schistosomes. The efficiency of related protein kinase inhibitors on schistosomes is highlighted. Finally, the current challenges and problems in the study of SjPKs are proposed, which can provide future guidance for developing anti-schistosomiasis drugs and vaccines.https://www.frontiersin.org/articles/10.3389/fcimb.2021.691757/fullschistosomiasisSchistosoma japonicumprotein kinasesdrug targetskinase inhibitors |
| spellingShingle | Kaijuan Wu Kaijuan Wu Xingyu Zhai Xingyu Zhai Shuaiqin Huang Liping Jiang Liping Jiang Zheng Yu Zheng Yu Jing Huang Jing Huang Protein Kinases: Potential Drug Targets Against Schistosoma japonicum Frontiers in Cellular and Infection Microbiology schistosomiasis Schistosoma japonicum protein kinases drug targets kinase inhibitors |
| title | Protein Kinases: Potential Drug Targets Against Schistosoma japonicum |
| title_full | Protein Kinases: Potential Drug Targets Against Schistosoma japonicum |
| title_fullStr | Protein Kinases: Potential Drug Targets Against Schistosoma japonicum |
| title_full_unstemmed | Protein Kinases: Potential Drug Targets Against Schistosoma japonicum |
| title_short | Protein Kinases: Potential Drug Targets Against Schistosoma japonicum |
| title_sort | protein kinases potential drug targets against schistosoma japonicum |
| topic | schistosomiasis Schistosoma japonicum protein kinases drug targets kinase inhibitors |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.691757/full |
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