Hyperhomocysteinemia and acute phase proteins in various forms of ischemic heart disease
Aim. To determine clinical significance of high concentrations of homocystein, C-reactive protein, fibrinogen in various forms of ischemic heart disease. Material and methods. Enzyme immunoassay was made to measure serum concentrations of homocystein, C-reactive protein, fibrinogen in 60 patients wi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2004-06-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/29849 |
| _version_ | 1819082849627668480 |
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| author | A D Paramonov S V Moiseev V V Fomin M V Kopeleva L I Stankevich A I Martynov N A Mukhin |
| author_facet | A D Paramonov S V Moiseev V V Fomin M V Kopeleva L I Stankevich A I Martynov N A Mukhin |
| author_sort | A D Paramonov |
| collection | DOAJ |
| description | Aim. To determine clinical significance of high concentrations of homocystein, C-reactive protein, fibrinogen in various forms of ischemic heart disease.
Material and methods. Enzyme immunoassay was made to measure serum concentrations of homocystein, C-reactive protein, fibrinogen in 60 patients with ischemic heart disease (IHD) in the form of stable effort angina (n = 20), painless myocardial ischemia (n = 19), unstable angina pectoris (n = 21) and 20 control patients free of IHD. Myocardial ischemia was confirmed at dobutamine stress echocardiography.
Results. Serum concentrations of homocysteine, C-reactive protein and fibrinogen were higher in patients with unstable angina than in the other examinees with IHD. A statictically significant correlation exists between homocysteine serum levels and acute phase proteins (C-reactive protein, fibrinogen) in patients with unstable angina. In the other groups it was absent.
Conclusion. Correlation between serum levels of homocysteine and acute phase proteins in patients with unstable angina suggests a direct participation of this amino acid in destabilization of atherosclerotic plaques and development of acute coronary syndromes. |
| first_indexed | 2024-12-21T20:23:13Z |
| format | Article |
| id | doaj.art-9a4b5293c004481895cf91ff5f4a700c |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-21T20:23:13Z |
| publishDate | 2004-06-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-9a4b5293c004481895cf91ff5f4a700c2022-12-21T18:51:26Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422004-06-01796677026877Hyperhomocysteinemia and acute phase proteins in various forms of ischemic heart diseaseA D ParamonovS V MoiseevV V FominM V KopelevaL I StankevichA I MartynovN A MukhinAim. To determine clinical significance of high concentrations of homocystein, C-reactive protein, fibrinogen in various forms of ischemic heart disease. Material and methods. Enzyme immunoassay was made to measure serum concentrations of homocystein, C-reactive protein, fibrinogen in 60 patients with ischemic heart disease (IHD) in the form of stable effort angina (n = 20), painless myocardial ischemia (n = 19), unstable angina pectoris (n = 21) and 20 control patients free of IHD. Myocardial ischemia was confirmed at dobutamine stress echocardiography. Results. Serum concentrations of homocysteine, C-reactive protein and fibrinogen were higher in patients with unstable angina than in the other examinees with IHD. A statictically significant correlation exists between homocysteine serum levels and acute phase proteins (C-reactive protein, fibrinogen) in patients with unstable angina. In the other groups it was absent. Conclusion. Correlation between serum levels of homocysteine and acute phase proteins in patients with unstable angina suggests a direct participation of this amino acid in destabilization of atherosclerotic plaques and development of acute coronary syndromes.https://ter-arkhiv.ru/0040-3660/article/view/29849ischemic heart diseasehyperhomocysteinemiac-reactive proteinfibrinogenunstable anginastress-echocardiography |
| spellingShingle | A D Paramonov S V Moiseev V V Fomin M V Kopeleva L I Stankevich A I Martynov N A Mukhin Hyperhomocysteinemia and acute phase proteins in various forms of ischemic heart disease Терапевтический архив ischemic heart disease hyperhomocysteinemia c-reactive protein fibrinogen unstable angina stress-echocardiography |
| title | Hyperhomocysteinemia and acute phase proteins in various forms of ischemic heart disease |
| title_full | Hyperhomocysteinemia and acute phase proteins in various forms of ischemic heart disease |
| title_fullStr | Hyperhomocysteinemia and acute phase proteins in various forms of ischemic heart disease |
| title_full_unstemmed | Hyperhomocysteinemia and acute phase proteins in various forms of ischemic heart disease |
| title_short | Hyperhomocysteinemia and acute phase proteins in various forms of ischemic heart disease |
| title_sort | hyperhomocysteinemia and acute phase proteins in various forms of ischemic heart disease |
| topic | ischemic heart disease hyperhomocysteinemia c-reactive protein fibrinogen unstable angina stress-echocardiography |
| url | https://ter-arkhiv.ru/0040-3660/article/view/29849 |
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