Differences in Viral RNA Synthesis but Not Budding or Entry Contribute to the In Vitro Attenuation of Reston Virus Compared to Ebola Virus

Differences in Viral RNA Synthesis but Not Budding or Entry Contribute to the In Vitro Attenuation of Reston Virus Compared to Ebola Virus

Most filoviruses cause severe disease in humans. For example, Ebola virus (EBOV) is responsible for the two most extensive outbreaks of filovirus disease to date, with case fatality rates of 66% and 40%, respectively. In contrast, Reston virus (RESTV) is apparently apathogenic in humans, and while t...

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Bibliographic Details
Main Authors: Bianca S. Bodmer, Josephin Greßler, Marie L. Schmidt, Julia Holzerland, Janine Brandt, Stefanie Braun, Allison Groseth, Thomas Hoenen
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Microorganisms
Subjects:
Ebola virus
Reston virus
filovirus
pathogenicity
RNA synthesis
budding
Online Access:https://www.mdpi.com/2076-2607/8/8/1215

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