Low doses of propofol and midazolam on maternal hemodynamic symptoms and neonatal Apgar in women undergoing spinal anesthesia in cesarean section: A double-blind randomized clinical trial study
Introduction: Regional anesthesia is the method of choice in cesarean section. Intravenous sleeping pills used to induce anesthesia quickly cross the placenta and cause fetal respiration depression. This study was performed with aim to compare the low dose of propofol with midazolam on the maternal...
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| Format: | Article |
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Mashhad University of Medical Sciences
2021-04-01
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| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
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| Online Access: | https://ijogi.mums.ac.ir/article_18171_5d40ddf227a176c2e0ea99687539814d.pdf |
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| author | Majid Vatankhah Seyed Ebrahim Sadeghi Mohammad Zarenezhad Athar Rasekh Jahromi Navid Kalani Naser Hatami Farshid Javdani Hasan Zabetian |
| author_facet | Majid Vatankhah Seyed Ebrahim Sadeghi Mohammad Zarenezhad Athar Rasekh Jahromi Navid Kalani Naser Hatami Farshid Javdani Hasan Zabetian |
| author_sort | Majid Vatankhah |
| collection | DOAJ |
| description | Introduction: Regional anesthesia is the method of choice in cesarean section. Intravenous sleeping pills used to induce anesthesia quickly cross the placenta and cause fetal respiration depression. This study was performed with aim to compare the low dose of propofol with midazolam on the maternal hemodynamics symptoms and neonatal Apgar in women undergoing spinal anesthesia in cesarean section. Methods: In this double-blind randomized clinical trial study which was performed in Jahrom in 2013, 42 patients with anesthesia classes I and II underwent spinal anesthesia and were placed in two equal groups of injection of propofol 20 mg and midazolam 1.5 mg along with spinal anesthesia. Symptoms of maternal hemodynamics were measured at 1, 3, 5, 10, 15, 30, and 60 minutes after spinal anesthesia and neonatal apgar at 1 and 5 minutes after birth. Data were analyzed by SPSS software (version 21) and Mann-Whitney test. p < 0.05 was considered statistically significant. Results: There was no significant difference between midazolam and propofol groups in terms of systolic and diastolic blood pressure, Blood O2 saturation, and hear rate at different times and neonatal Apgar (P> 0.05). Conclusion: Considering the results of the study and no difference between the two groups in terms of neonatal Apgar and fluctuations of maternal hemodynamic variables, it can be concluded that under normal conditions, low doses of propofol and midazolam for cesarean section clinically have no significant difference on neonatal Apgar and hemodynamic variables; both drugs can be used depending on the condition and experience of the anesthesiologist. |
| first_indexed | 2024-04-11T07:04:38Z |
| format | Article |
| id | doaj.art-9a4e73d49a544311a317c12054a7fa47 |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-04-11T07:04:38Z |
| publishDate | 2021-04-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-9a4e73d49a544311a317c12054a7fa472022-12-22T04:38:25ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632021-04-01242414910.22038/ijogi.2021.1817118171Low doses of propofol and midazolam on maternal hemodynamic symptoms and neonatal Apgar in women undergoing spinal anesthesia in cesarean section: A double-blind randomized clinical trial studyMajid Vatankhah0Seyed Ebrahim Sadeghi1Mohammad Zarenezhad2Athar Rasekh Jahromi3Navid Kalani4Naser Hatami5Farshid Javdani6Hasan Zabetian7Assistant Professor, Department of Anesthesiology, Anesthesiology & Critical Care and Pain Management Research Center, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.Assistant Professor, Department of Anesthesiology, Faculty of Medicine, Shiraz University of Medical sciences, Shiraz, Iran.PhD in Medical Genetic, Department of Forensic Sciences, Iranian Legal Medicine Research Center, Tehran, Iran.Assistant Professor, Department of Obstetrics and Gynecology, Women’s Health and Disease Research Center, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.Instructor, Department of Anesthesiology, Anesthesiology and Pain Management Research Center, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.Medical student, Student Research Committee, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.Medical student, Student Research Committee, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.Associate Professor, Department of Anesthesiology, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.Introduction: Regional anesthesia is the method of choice in cesarean section. Intravenous sleeping pills used to induce anesthesia quickly cross the placenta and cause fetal respiration depression. This study was performed with aim to compare the low dose of propofol with midazolam on the maternal hemodynamics symptoms and neonatal Apgar in women undergoing spinal anesthesia in cesarean section. Methods: In this double-blind randomized clinical trial study which was performed in Jahrom in 2013, 42 patients with anesthesia classes I and II underwent spinal anesthesia and were placed in two equal groups of injection of propofol 20 mg and midazolam 1.5 mg along with spinal anesthesia. Symptoms of maternal hemodynamics were measured at 1, 3, 5, 10, 15, 30, and 60 minutes after spinal anesthesia and neonatal apgar at 1 and 5 minutes after birth. Data were analyzed by SPSS software (version 21) and Mann-Whitney test. p < 0.05 was considered statistically significant. Results: There was no significant difference between midazolam and propofol groups in terms of systolic and diastolic blood pressure, Blood O2 saturation, and hear rate at different times and neonatal Apgar (P> 0.05). Conclusion: Considering the results of the study and no difference between the two groups in terms of neonatal Apgar and fluctuations of maternal hemodynamic variables, it can be concluded that under normal conditions, low doses of propofol and midazolam for cesarean section clinically have no significant difference on neonatal Apgar and hemodynamic variables; both drugs can be used depending on the condition and experience of the anesthesiologist.https://ijogi.mums.ac.ir/article_18171_5d40ddf227a176c2e0ea99687539814d.pdfcesarean sectionhemodynamic symptomsmidazolamneonatal apgarpropofol |
| spellingShingle | Majid Vatankhah Seyed Ebrahim Sadeghi Mohammad Zarenezhad Athar Rasekh Jahromi Navid Kalani Naser Hatami Farshid Javdani Hasan Zabetian Low doses of propofol and midazolam on maternal hemodynamic symptoms and neonatal Apgar in women undergoing spinal anesthesia in cesarean section: A double-blind randomized clinical trial study Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān cesarean section hemodynamic symptoms midazolam neonatal apgar propofol |
| title | Low doses of propofol and midazolam on maternal hemodynamic symptoms and neonatal Apgar in women undergoing spinal anesthesia in cesarean section: A double-blind randomized clinical trial study |
| title_full | Low doses of propofol and midazolam on maternal hemodynamic symptoms and neonatal Apgar in women undergoing spinal anesthesia in cesarean section: A double-blind randomized clinical trial study |
| title_fullStr | Low doses of propofol and midazolam on maternal hemodynamic symptoms and neonatal Apgar in women undergoing spinal anesthesia in cesarean section: A double-blind randomized clinical trial study |
| title_full_unstemmed | Low doses of propofol and midazolam on maternal hemodynamic symptoms and neonatal Apgar in women undergoing spinal anesthesia in cesarean section: A double-blind randomized clinical trial study |
| title_short | Low doses of propofol and midazolam on maternal hemodynamic symptoms and neonatal Apgar in women undergoing spinal anesthesia in cesarean section: A double-blind randomized clinical trial study |
| title_sort | low doses of propofol and midazolam on maternal hemodynamic symptoms and neonatal apgar in women undergoing spinal anesthesia in cesarean section a double blind randomized clinical trial study |
| topic | cesarean section hemodynamic symptoms midazolam neonatal apgar propofol |
| url | https://ijogi.mums.ac.ir/article_18171_5d40ddf227a176c2e0ea99687539814d.pdf |
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