Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS

Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS

Prokaryotic mechanosensitive (MS) channels open by sensing the physical state of the membrane. As such, lipid-protein interactions represent the defining molecular process underlying mechanotransduction. Here, we describe cryo-electron microscopy (cryo-EM) structures of the E. coli small-conductance...

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Bibliographic Details
Main Authors: Bharat Reddy, Navid Bavi, Allen Lu, Yeonwoo Park, Eduardo Perozo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
mechanotransduction
force-from-lipid gating
MscS
Cryo-EM
Online Access:https://elifesciences.org/articles/50486

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