Factors Affecting Quality of Life in Liver Transplant Candidates: An Observational Study
Health-related quality of life (HRQOL) before and after liver transplant (LT) is an important outcome in LT candidates as, in these patients, HRQOL is commonly impaired. However, evidence regarding factors that influence HRQOL in patients with end-stage liver disease is inconclusive. The aim of the...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Transplantology |
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| Online Access: | https://www.mdpi.com/2673-3943/2/1/7 |
| _version_ | 1797414877304717312 |
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| author | Ana Isabel López-Lazcano Hugo López-Pelayo Antoni Gual Anna Lligoña Vanessa Vilas-Riotorto Elsa Caballeria Pol Bruguera Luis Pintor |
| author_facet | Ana Isabel López-Lazcano Hugo López-Pelayo Antoni Gual Anna Lligoña Vanessa Vilas-Riotorto Elsa Caballeria Pol Bruguera Luis Pintor |
| author_sort | Ana Isabel López-Lazcano |
| collection | DOAJ |
| description | Health-related quality of life (HRQOL) before and after liver transplant (LT) is an important outcome in LT candidates as, in these patients, HRQOL is commonly impaired. However, evidence regarding factors that influence HRQOL in patients with end-stage liver disease is inconclusive. The aim of the present study was to identify factors associated with poor HRQOL. An observational study was conducted over LT candidates. The 36-item Short Form Health Survey (widely used to assess HRQOL) and the Hospital Anxiety and Depression Scale were administered to 211 patients during the pre-transplant assessment. Baseline demographic and clinical data were also collected. Multiple regression analysis was performed to investigate risk factors for poor HRQOL. Female sex (lower B = 7.99 95%C = 0.07–15.92, higher B = 18.09 95%CI = 7.56–28.62), encephalopathy (lower B = −9.45, 95%CI = −14.59–−4.31, higher B = −6.69, 95%CI = −13.13 to −0.25), higher MELD scores (lower B = −1.14, 95%CI = −1.67 to −0.61, higher B = −0.33, 95%CI = −0.65 to −0.12), anxiety (lower B = −3.04 95%C = −4.71 to −1.36, higher B = −1.93 95%CI = −3.39 to −0.47)and depression (lower B = −3.27 95%C = −4.46 to −2.08, higher B = −1.02 95%CI = −1.90 to −0.13) symptoms were associated to poorer HRQOL. Psychosocial interventions should be addressed to liver transplant candidates, especially to women, patients with anxiety, depression or episodes of encephalopathy, in order to prevent the impact that these conditions can have on HRQOL. |
| first_indexed | 2024-03-09T05:40:23Z |
| format | Article |
| id | doaj.art-9a4f3881a25d4dcb8fe3412a15b1613a |
| institution | Directory Open Access Journal |
| issn | 2673-3943 |
| language | English |
| last_indexed | 2024-03-09T05:40:23Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Transplantology |
| spelling | doaj.art-9a4f3881a25d4dcb8fe3412a15b1613a2023-12-03T12:25:19ZengMDPI AGTransplantology2673-39432021-03-0121647410.3390/transplantology2010007Factors Affecting Quality of Life in Liver Transplant Candidates: An Observational StudyAna Isabel López-Lazcano0Hugo López-Pelayo1Antoni Gual2Anna Lligoña3Vanessa Vilas-Riotorto4Elsa Caballeria5Pol Bruguera6Luis Pintor7Grup Recerca Addicions Clínic (GRAC-GRE), Department of Psychiatry and Psychology, Clinical Institute of Neuroscience, Hospital Clínic i Universitari de Barcelona, Universitat de Barcelona, IDIBAPS, RTA (RETICS), Villarroel, 170, 08036 Barcelona, SpainGrup Recerca Addicions Clínic (GRAC-GRE), Department of Psychiatry and Psychology, Clinical Institute of Neuroscience, Hospital Clínic i Universitari de Barcelona, Universitat de Barcelona, IDIBAPS, RTA (RETICS), Villarroel, 170, 08036 Barcelona, SpainGrup Recerca Addicions Clínic (GRAC-GRE), Department of Psychiatry and Psychology, Clinical Institute of Neuroscience, Hospital Clínic i Universitari de Barcelona, Universitat de Barcelona, IDIBAPS, RTA (RETICS), Villarroel, 170, 08036 Barcelona, SpainGrup Recerca Addicions Clínic (GRAC-GRE), Department of Psychiatry and Psychology, Clinical Institute of Neuroscience, Hospital Clínic i Universitari de Barcelona, Universitat de Barcelona, IDIBAPS, RTA (RETICS), Villarroel, 170, 08036 Barcelona, SpainHealth Clinical Psychology Unit, Department of Psychiatry and Psychology, Clinical Institute of Neurosciences, Hospital Clínic i Universitari de Barcelona, Universitat de Barcelona, Villarroel, 170, 08036 Barcelona, SpainGrup Recerca Addicions Clínic (GRAC-GRE), Department of Psychiatry and Psychology, Clinical Institute of Neuroscience, Hospital Clínic i Universitari de Barcelona, Universitat de Barcelona, IDIBAPS, RTA (RETICS), Villarroel, 170, 08036 Barcelona, SpainGrup Recerca Addicions Clínic (GRAC-GRE), Department of Psychiatry and Psychology, Clinical Institute of Neuroscience, Hospital Clínic i Universitari de Barcelona, Universitat de Barcelona, IDIBAPS, RTA (RETICS), Villarroel, 170, 08036 Barcelona, SpainConsultation Liaison Psychiatry Unit, Department of Psychiatry and Psychology, Clinical Institute of Neurosciences, Hospital Clínic i Universitari de Barcelona, Universitat de Barcelona, Villarroel, 170, 08036 Barcelona, SpainHealth-related quality of life (HRQOL) before and after liver transplant (LT) is an important outcome in LT candidates as, in these patients, HRQOL is commonly impaired. However, evidence regarding factors that influence HRQOL in patients with end-stage liver disease is inconclusive. The aim of the present study was to identify factors associated with poor HRQOL. An observational study was conducted over LT candidates. The 36-item Short Form Health Survey (widely used to assess HRQOL) and the Hospital Anxiety and Depression Scale were administered to 211 patients during the pre-transplant assessment. Baseline demographic and clinical data were also collected. Multiple regression analysis was performed to investigate risk factors for poor HRQOL. Female sex (lower B = 7.99 95%C = 0.07–15.92, higher B = 18.09 95%CI = 7.56–28.62), encephalopathy (lower B = −9.45, 95%CI = −14.59–−4.31, higher B = −6.69, 95%CI = −13.13 to −0.25), higher MELD scores (lower B = −1.14, 95%CI = −1.67 to −0.61, higher B = −0.33, 95%CI = −0.65 to −0.12), anxiety (lower B = −3.04 95%C = −4.71 to −1.36, higher B = −1.93 95%CI = −3.39 to −0.47)and depression (lower B = −3.27 95%C = −4.46 to −2.08, higher B = −1.02 95%CI = −1.90 to −0.13) symptoms were associated to poorer HRQOL. Psychosocial interventions should be addressed to liver transplant candidates, especially to women, patients with anxiety, depression or episodes of encephalopathy, in order to prevent the impact that these conditions can have on HRQOL.https://www.mdpi.com/2673-3943/2/1/7liver transplantquality of lifeanxietydepressionpsychosocial factors |
| spellingShingle | Ana Isabel López-Lazcano Hugo López-Pelayo Antoni Gual Anna Lligoña Vanessa Vilas-Riotorto Elsa Caballeria Pol Bruguera Luis Pintor Factors Affecting Quality of Life in Liver Transplant Candidates: An Observational Study Transplantology liver transplant quality of life anxiety depression psychosocial factors |
| title | Factors Affecting Quality of Life in Liver Transplant Candidates: An Observational Study |
| title_full | Factors Affecting Quality of Life in Liver Transplant Candidates: An Observational Study |
| title_fullStr | Factors Affecting Quality of Life in Liver Transplant Candidates: An Observational Study |
| title_full_unstemmed | Factors Affecting Quality of Life in Liver Transplant Candidates: An Observational Study |
| title_short | Factors Affecting Quality of Life in Liver Transplant Candidates: An Observational Study |
| title_sort | factors affecting quality of life in liver transplant candidates an observational study |
| topic | liver transplant quality of life anxiety depression psychosocial factors |
| url | https://www.mdpi.com/2673-3943/2/1/7 |
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