A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa
A new ionone glycoside, frehmaglutoside I (1), and three new rhemaneolignans A–C (2–4) were isolated from the 95% EtOH extract of the roots of Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these compounds we...
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MDPI AG
2015-08-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/20/8/15192 |
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| author | Meng Li Xiaolan Wang Xiaoke Zheng Jianchao Wang Wei Zhao Kai Song Xuan Zhao Yanli Zhang Haixue Kuang Weisheng Feng |
| author_facet | Meng Li Xiaolan Wang Xiaoke Zheng Jianchao Wang Wei Zhao Kai Song Xuan Zhao Yanli Zhang Haixue Kuang Weisheng Feng |
| author_sort | Meng Li |
| collection | DOAJ |
| description | A new ionone glycoside, frehmaglutoside I (1), and three new rhemaneolignans A–C (2–4) were isolated from the 95% EtOH extract of the roots of Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these compounds were evaluated for their protective effects on cardiocytes impaired by doxorubicin in H9c2 cells. Among them, compounds 1–3 exhibited protective effects against DOX-induced cardiotoxicity. |
| first_indexed | 2024-04-12T13:25:21Z |
| format | Article |
| id | doaj.art-9a50e587b0a840ccb550b58fba4865d7 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T13:25:21Z |
| publishDate | 2015-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9a50e587b0a840ccb550b58fba4865d72022-12-22T03:31:20ZengMDPI AGMolecules1420-30492015-08-01208151921520110.3390/molecules200815192molecules200815192A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosaMeng Li0Xiaolan Wang1Xiaoke Zheng2Jianchao Wang3Wei Zhao4Kai Song5Xuan Zhao6Yanli Zhang7Haixue Kuang8Weisheng Feng9School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, ChinaSchool of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaCollaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, ChinaA new ionone glycoside, frehmaglutoside I (1), and three new rhemaneolignans A–C (2–4) were isolated from the 95% EtOH extract of the roots of Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these compounds were evaluated for their protective effects on cardiocytes impaired by doxorubicin in H9c2 cells. Among them, compounds 1–3 exhibited protective effects against DOX-induced cardiotoxicity.http://www.mdpi.com/1420-3049/20/8/15192Rehmannia glutinosaionone glycosiderhemaneolignansthe protective effects of cardiomyocytes |
| spellingShingle | Meng Li Xiaolan Wang Xiaoke Zheng Jianchao Wang Wei Zhao Kai Song Xuan Zhao Yanli Zhang Haixue Kuang Weisheng Feng A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa Molecules Rehmannia glutinosa ionone glycoside rhemaneolignans the protective effects of cardiomyocytes |
| title | A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa |
| title_full | A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa |
| title_fullStr | A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa |
| title_full_unstemmed | A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa |
| title_short | A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa |
| title_sort | new ionone glycoside and three new rhemaneolignans from the roots of rehmannia glutinosa |
| topic | Rehmannia glutinosa ionone glycoside rhemaneolignans the protective effects of cardiomyocytes |
| url | http://www.mdpi.com/1420-3049/20/8/15192 |
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