The role of FDG PET/CT in the evaluation of treatment response in a case of calcified ovarian metastases
Evaluation of calcified metastatic lesions by conventional imaging can be challenging. Ovarian cancer metastases can present with calcification which might increase in size and number following therapy. It is not entirely clear whether these calcifications are associated with tumor response or disea...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2020-07-01
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| Series: | Asia Oceania Journal of Nuclear Medicine and Biology |
| Subjects: | |
| Online Access: | http://aojnmb.mums.ac.ir/article_15924_9a92da1c10274d19a26adfe08a5c61cf.pdf |
| _version_ | 1828883549142384640 |
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| author | Bahare Saidi Babak Fallahi Mohammad Eftekhari Mahsa Ghorbani Armaghan Fard-Esfahani |
| author_facet | Bahare Saidi Babak Fallahi Mohammad Eftekhari Mahsa Ghorbani Armaghan Fard-Esfahani |
| author_sort | Bahare Saidi |
| collection | DOAJ |
| description | Evaluation of calcified metastatic lesions by conventional imaging can be challenging. Ovarian cancer metastases can present with calcification which might increase in size and number following therapy. It is not entirely clear whether these calcifications are associated with tumor response or disease progression. Calcified lesions which do not change in size or configuration are particularly problematic when assessed by RECIST criteria. Positron emission tomography (PET)/computed tomography (CT) is of particular value as it demonstrates the metabolic activity of the calcified lesions, in addition, it might reveal metastases in unexpected sites. We report a case of serous papillary ovarian cancer with extensive abdomino-pelvic calcified metastases referred for evaluation of therapy response. Despite being reported as stable disease on CT evaluation, we observed increased metabolic activity in the calcified lesions both on CT-attenuation corrected and non-attenuation corrected images, which was indicative of inadequate response to therapy. PET/CT is an ideal modality in follow-up of patients with ovarian cancer presenting with calcified metastatic tumoral deposits. |
| first_indexed | 2024-12-13T10:50:37Z |
| format | Article |
| id | doaj.art-9a50f53893ce41928a7298b369610d0e |
| institution | Directory Open Access Journal |
| issn | 2322-5718 2322-5726 |
| language | English |
| last_indexed | 2024-12-13T10:50:37Z |
| publishDate | 2020-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Asia Oceania Journal of Nuclear Medicine and Biology |
| spelling | doaj.art-9a50f53893ce41928a7298b369610d0e2022-12-21T23:49:51ZengMashhad University of Medical SciencesAsia Oceania Journal of Nuclear Medicine and Biology2322-57182322-57262020-07-018214514810.22038/aojnmb.2020.47216.131615924The role of FDG PET/CT in the evaluation of treatment response in a case of calcified ovarian metastasesBahare Saidi0Babak Fallahi1Mohammad Eftekhari2Mahsa Ghorbani3Armaghan Fard-Esfahani4Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranResearch Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranResearch Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranDepartment of Nuclear Medicine, Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, IranResearch Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranEvaluation of calcified metastatic lesions by conventional imaging can be challenging. Ovarian cancer metastases can present with calcification which might increase in size and number following therapy. It is not entirely clear whether these calcifications are associated with tumor response or disease progression. Calcified lesions which do not change in size or configuration are particularly problematic when assessed by RECIST criteria. Positron emission tomography (PET)/computed tomography (CT) is of particular value as it demonstrates the metabolic activity of the calcified lesions, in addition, it might reveal metastases in unexpected sites. We report a case of serous papillary ovarian cancer with extensive abdomino-pelvic calcified metastases referred for evaluation of therapy response. Despite being reported as stable disease on CT evaluation, we observed increased metabolic activity in the calcified lesions both on CT-attenuation corrected and non-attenuation corrected images, which was indicative of inadequate response to therapy. PET/CT is an ideal modality in follow-up of patients with ovarian cancer presenting with calcified metastatic tumoral deposits.http://aojnmb.mums.ac.ir/article_15924_9a92da1c10274d19a26adfe08a5c61cf.pdfcalcified metastasesovary cancerpet/ct |
| spellingShingle | Bahare Saidi Babak Fallahi Mohammad Eftekhari Mahsa Ghorbani Armaghan Fard-Esfahani The role of FDG PET/CT in the evaluation of treatment response in a case of calcified ovarian metastases Asia Oceania Journal of Nuclear Medicine and Biology calcified metastases ovary cancer pet/ct |
| title | The role of FDG PET/CT in the evaluation of treatment response in a case of calcified ovarian metastases |
| title_full | The role of FDG PET/CT in the evaluation of treatment response in a case of calcified ovarian metastases |
| title_fullStr | The role of FDG PET/CT in the evaluation of treatment response in a case of calcified ovarian metastases |
| title_full_unstemmed | The role of FDG PET/CT in the evaluation of treatment response in a case of calcified ovarian metastases |
| title_short | The role of FDG PET/CT in the evaluation of treatment response in a case of calcified ovarian metastases |
| title_sort | role of fdg pet ct in the evaluation of treatment response in a case of calcified ovarian metastases |
| topic | calcified metastases ovary cancer pet/ct |
| url | http://aojnmb.mums.ac.ir/article_15924_9a92da1c10274d19a26adfe08a5c61cf.pdf |
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