Prognostic value of the histopathologic private characteristics of breast cancer in patients with no axillary lymph node involvement
The biological behavior of breast cancer supports the impression that it is often a systemic disease which can recur many years after the treatment of the local lesion. Since 35% of patients without axillary nodal metastasis will have recurrence of the disease after mastectomy, prognostic indicators...
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Associação Paulista de Medicina
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| Series: | São Paulo Medical Journal |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801994000100010&lng=en&tlng=en |
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| author | Luiz Henrique Gebrim Geraldo Rodrigues de Lima Osvaldo Gianotti Filho Elci Barreto Fausto F. Baracat Hartmut H. Grabert |
| author_facet | Luiz Henrique Gebrim Geraldo Rodrigues de Lima Osvaldo Gianotti Filho Elci Barreto Fausto F. Baracat Hartmut H. Grabert |
| author_sort | Luiz Henrique Gebrim |
| collection | DOAJ |
| description | The biological behavior of breast cancer supports the impression that it is often a systemic disease which can recur many years after the treatment of the local lesion. Since 35% of patients without axillary nodal metastasis will have recurrence of the disease after mastectomy, prognostic indicators are necessary to identify the high-risk patients to allow a more rational adjuvant therapy. We studied the prognostic value of fatty tissue invasion, perineural involvement and lymphatic and venous peritumoral embolization in T2NOMO primary breast carcinomas. Fifty-three patients were studied after initial treatment (only Halsted mastectomy). They were divided into two groups: A (control), with 25 patients with 15 years of survival without clinical and laboratory evidence of metastasis, and group B, with 28 patients who developed metastasis after initial treatment. The results were analysed by the chi-square test (p<0.05). The fatty tissue invasion was identified in 56.0% and 78.5% in the A and B groups respectively, while venous embolization was only detected in 8.0% of the group A tumors and in 10.7% of those in group B. Neither showed significant variation when analyzed according to the chi-square test. Lymphatic embolization and perineural involvement were found respectively in 36.0% and 40.0% in the group A tumors and in 67.8% and 71.4% of those in group B, exhibiting a significant statistical variation. When analysing the histopathological characteristics in the pre- and post-menopausal patients, the chi-square test disclosed that lymphatic embolization and perineural involvement had a significantly higher incidence only in pre-menopausal patients in group B. |
| first_indexed | 2024-04-12T10:57:04Z |
| format | Article |
| id | doaj.art-9a5203a42ae74a7cb63c61b85d175981 |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-04-12T10:57:04Z |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-9a5203a42ae74a7cb63c61b85d1759812022-12-22T03:36:04ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-9460112152252810.1590/S1516-31801994000100010S1516-31801994000100010Prognostic value of the histopathologic private characteristics of breast cancer in patients with no axillary lymph node involvementLuiz Henrique GebrimGeraldo Rodrigues de LimaOsvaldo Gianotti FilhoElci BarretoFausto F. BaracatHartmut H. GrabertThe biological behavior of breast cancer supports the impression that it is often a systemic disease which can recur many years after the treatment of the local lesion. Since 35% of patients without axillary nodal metastasis will have recurrence of the disease after mastectomy, prognostic indicators are necessary to identify the high-risk patients to allow a more rational adjuvant therapy. We studied the prognostic value of fatty tissue invasion, perineural involvement and lymphatic and venous peritumoral embolization in T2NOMO primary breast carcinomas. Fifty-three patients were studied after initial treatment (only Halsted mastectomy). They were divided into two groups: A (control), with 25 patients with 15 years of survival without clinical and laboratory evidence of metastasis, and group B, with 28 patients who developed metastasis after initial treatment. The results were analysed by the chi-square test (p<0.05). The fatty tissue invasion was identified in 56.0% and 78.5% in the A and B groups respectively, while venous embolization was only detected in 8.0% of the group A tumors and in 10.7% of those in group B. Neither showed significant variation when analyzed according to the chi-square test. Lymphatic embolization and perineural involvement were found respectively in 36.0% and 40.0% in the group A tumors and in 67.8% and 71.4% of those in group B, exhibiting a significant statistical variation. When analysing the histopathological characteristics in the pre- and post-menopausal patients, the chi-square test disclosed that lymphatic embolization and perineural involvement had a significantly higher incidence only in pre-menopausal patients in group B.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801994000100010&lng=en&tlng=enbreast cancernode negativehistopathologyprognosis |
| spellingShingle | Luiz Henrique Gebrim Geraldo Rodrigues de Lima Osvaldo Gianotti Filho Elci Barreto Fausto F. Baracat Hartmut H. Grabert Prognostic value of the histopathologic private characteristics of breast cancer in patients with no axillary lymph node involvement São Paulo Medical Journal breast cancer node negative histopathology prognosis |
| title | Prognostic value of the histopathologic private characteristics of breast cancer in patients with no axillary lymph node involvement |
| title_full | Prognostic value of the histopathologic private characteristics of breast cancer in patients with no axillary lymph node involvement |
| title_fullStr | Prognostic value of the histopathologic private characteristics of breast cancer in patients with no axillary lymph node involvement |
| title_full_unstemmed | Prognostic value of the histopathologic private characteristics of breast cancer in patients with no axillary lymph node involvement |
| title_short | Prognostic value of the histopathologic private characteristics of breast cancer in patients with no axillary lymph node involvement |
| title_sort | prognostic value of the histopathologic private characteristics of breast cancer in patients with no axillary lymph node involvement |
| topic | breast cancer node negative histopathology prognosis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801994000100010&lng=en&tlng=en |
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