Structural Insight into the In Vitro Anti-Intravasative Properties of Flavonoids

Structural Insight into the In Vitro Anti-Intravasative Properties of Flavonoids

We investigated the effect of 21 flavonoids in a three-dimensional in vitro system for their ability to inhibit gap formation by MCF-7 breast cancer spheroids in monolayers of lymphendothelial cells. Different representatives of the classes of flavones, flavonols, and flavanones were tested in the c...

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Bibliographic Details
Main Authors: Julia Eichsteininger, Kerstin Kirisits, Claudia Smöch, Christa Stadlbauer, Chi Huu Nguyen, Walter Jäger, Ali Özmen, Gerhard Ecker, Georg Krupitza, Liselotte Krenn
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Scientia Pharmaceutica
Subjects:
CCID assay
inhibition of gap formation
flavonoids
anti-invasive
breast cancer
structure-activity relationship
Online Access:https://www.mdpi.com/2218-0532/87/3/23

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