The differing effects of a dual acting regulator on SIRT1

The differing effects of a dual acting regulator on SIRT1

SIRT1 is an NAD+-dependent protein deacetylase that has been shown to play a significant role in many biological pathways, such as insulin secretion, tumor formation, lipid metabolism, and neurodegeneration. There is great interest in understanding the regulation of SIRT1 to better understand SIRT1-...

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Bibliographic Details
Main Authors: Yujin Hur, Johnson Huynh, Emily Leong, Reena Dosanjh, Annemarie F. Charvat, My H. Vu, Zain Alam, Yue Tong Lee, Christiane C. Cabreros, Emma C. Carroll, Greg L. Hura, Ningkun Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
allosteric regulation
enzyme kinetics
deacetylase
conformational change
SIRT1
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1260489/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1260489/full

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