Hypersensitivity and cross-reactivity to cisplatin and carboplatin
Cisplatin was the first of the platinum drugs. Second-generation platinum derivative was carboplatin that its efficacy in the treatment of many malignancies is equal to cisplatin, and its toxicity profile is more favorable. Here we report on a 50-year-old woman with a history of cervix cancer who...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Kerman University of Medical Sciences
2016-07-01
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| Series: | Journal of Emergency Practice and Trauma |
| Subjects: | |
| Online Access: | http://www.jept.ir/article_15487_cc7e8503f00163755fb27175dcbd54dd.pdf |
| _version_ | 1797793813785214976 |
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| author | Gholamreza Faridaalaee Amin Mahboubi Seyed Hesam Rahmani |
| author_facet | Gholamreza Faridaalaee Amin Mahboubi Seyed Hesam Rahmani |
| author_sort | Gholamreza Faridaalaee |
| collection | DOAJ |
| description | Cisplatin was the first of the platinum drugs. Second-generation platinum derivative
was carboplatin that its efficacy in the treatment of many malignancies is equal to
cisplatin, and its toxicity profile is more favorable. Here we report on a 50-year-old
woman with a history of cervix cancer who developed a severe hypersensitivity reaction
(HSR) to carboplatin. She was admitted to the emergency department (ED) with
shortness of breath, tachypnea, restless, agitation, and lethargy. On arrival, the patient
was hemodynamically unstable; we initiated treatment immediately with hydration,
oxygen therapy with mask, hydrocortisone, midazolam, and adrenalin. After 1 hour, BP
and O2
sat improved to 100/70 mm Hg and 92% respectively, but there was not any
significant improvement in tachycardia as well as tachypnea and she was still lethargic
and agitated. Her symptoms improved gradually after 18 hours of admission. She was
discharged after 36 hours. HSRs to cisplatin and carboplatin can be potentially lifethreatening. The symptoms can range from a mild rash to severe anaphylaxis. Doctors
should be aware of these reactions, determine appropriate treatment, and know the
cross-reactivity among these drugs. |
| first_indexed | 2024-03-13T02:53:46Z |
| format | Article |
| id | doaj.art-9a5427d3fc6e4e4687df9c99e30ad757 |
| institution | Directory Open Access Journal |
| issn | 2383-4544 |
| language | English |
| last_indexed | 2024-03-13T02:53:46Z |
| publishDate | 2016-07-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Emergency Practice and Trauma |
| spelling | doaj.art-9a5427d3fc6e4e4687df9c99e30ad7572023-06-28T08:33:52ZengKerman University of Medical SciencesJournal of Emergency Practice and Trauma2383-45442016-07-01225861https://doi.org/10.15171/jept.2016.09Hypersensitivity and cross-reactivity to cisplatin and carboplatinGholamreza Faridaalaee0Amin Mahboubi1Seyed Hesam Rahmani2Emergency Medicine Department, Maragheh University of Medical Sciences, Maragheh, IranEmergency Medicine Department, Maragheh University of Medical Sciences, Maragheh, IranEmergency Medicine Department, Urmia University of Medical Sciences, Urmia, IranCisplatin was the first of the platinum drugs. Second-generation platinum derivative was carboplatin that its efficacy in the treatment of many malignancies is equal to cisplatin, and its toxicity profile is more favorable. Here we report on a 50-year-old woman with a history of cervix cancer who developed a severe hypersensitivity reaction (HSR) to carboplatin. She was admitted to the emergency department (ED) with shortness of breath, tachypnea, restless, agitation, and lethargy. On arrival, the patient was hemodynamically unstable; we initiated treatment immediately with hydration, oxygen therapy with mask, hydrocortisone, midazolam, and adrenalin. After 1 hour, BP and O2 sat improved to 100/70 mm Hg and 92% respectively, but there was not any significant improvement in tachycardia as well as tachypnea and she was still lethargic and agitated. Her symptoms improved gradually after 18 hours of admission. She was discharged after 36 hours. HSRs to cisplatin and carboplatin can be potentially lifethreatening. The symptoms can range from a mild rash to severe anaphylaxis. Doctors should be aware of these reactions, determine appropriate treatment, and know the cross-reactivity among these drugs.http://www.jept.ir/article_15487_cc7e8503f00163755fb27175dcbd54dd.pdfcisplatincarboplatincross-reactivitycanceranaphylaxis |
| spellingShingle | Gholamreza Faridaalaee Amin Mahboubi Seyed Hesam Rahmani Hypersensitivity and cross-reactivity to cisplatin and carboplatin Journal of Emergency Practice and Trauma cisplatin carboplatin cross-reactivity cancer anaphylaxis |
| title | Hypersensitivity and cross-reactivity to cisplatin and carboplatin |
| title_full | Hypersensitivity and cross-reactivity to cisplatin and carboplatin |
| title_fullStr | Hypersensitivity and cross-reactivity to cisplatin and carboplatin |
| title_full_unstemmed | Hypersensitivity and cross-reactivity to cisplatin and carboplatin |
| title_short | Hypersensitivity and cross-reactivity to cisplatin and carboplatin |
| title_sort | hypersensitivity and cross reactivity to cisplatin and carboplatin |
| topic | cisplatin carboplatin cross-reactivity cancer anaphylaxis |
| url | http://www.jept.ir/article_15487_cc7e8503f00163755fb27175dcbd54dd.pdf |
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