DNA Damage and Its Role in Cancer Therapeutics
DNA damage is a double-edged sword in cancer cells. On the one hand, DNA damage exacerbates gene mutation frequency and cancer risk. Mutations in key DNA repair genes, such as breast cancer 1 (<i>BRCA1</i>) and/or breast cancer 2 (<i>BRCA2</i>), induce genomic instability and...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/5/4741 |
| _version_ | 1797615177229664256 |
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| author | Jaeyoung Moon Ichiwa Kitty Kusuma Renata Sisi Qin Fei Zhao Wootae Kim |
| author_facet | Jaeyoung Moon Ichiwa Kitty Kusuma Renata Sisi Qin Fei Zhao Wootae Kim |
| author_sort | Jaeyoung Moon |
| collection | DOAJ |
| description | DNA damage is a double-edged sword in cancer cells. On the one hand, DNA damage exacerbates gene mutation frequency and cancer risk. Mutations in key DNA repair genes, such as breast cancer 1 (<i>BRCA1</i>) and/or breast cancer 2 (<i>BRCA2</i>), induce genomic instability and promote tumorigenesis. On the other hand, the induction of DNA damage using chemical reagents or radiation kills cancer cells effectively. Cancer-burdening mutations in key DNA repair-related genes imply relatively high sensitivity to chemotherapy or radiotherapy because of reduced DNA repair efficiency. Therefore, designing specific inhibitors targeting key enzymes in the DNA repair pathway is an effective way to induce synthetic lethality with chemotherapy or radiotherapy in cancer therapeutics. This study reviews the general pathways involved in DNA repair in cancer cells and the potential proteins that could be targeted for cancer therapeutics. |
| first_indexed | 2024-03-11T07:22:47Z |
| format | Article |
| id | doaj.art-9a54461ea344401c8339ca6b9a6e4052 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T07:22:47Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9a54461ea344401c8339ca6b9a6e40522023-11-17T07:52:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01245474110.3390/ijms24054741DNA Damage and Its Role in Cancer TherapeuticsJaeyoung Moon0Ichiwa Kitty1Kusuma Renata2Sisi Qin3Fei Zhao4Wootae Kim5Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Chungcheongnam-do, Republic of KoreaDepartment of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Chungcheongnam-do, Republic of KoreaDepartment of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Chungcheongnam-do, Republic of KoreaDepartment of Pathology, University of Chicago, Chicago, IL 60637, USACollege of Biology, Hunan University, Changsha 410082, ChinaDepartment of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan 31151, Chungcheongnam-do, Republic of KoreaDNA damage is a double-edged sword in cancer cells. On the one hand, DNA damage exacerbates gene mutation frequency and cancer risk. Mutations in key DNA repair genes, such as breast cancer 1 (<i>BRCA1</i>) and/or breast cancer 2 (<i>BRCA2</i>), induce genomic instability and promote tumorigenesis. On the other hand, the induction of DNA damage using chemical reagents or radiation kills cancer cells effectively. Cancer-burdening mutations in key DNA repair-related genes imply relatively high sensitivity to chemotherapy or radiotherapy because of reduced DNA repair efficiency. Therefore, designing specific inhibitors targeting key enzymes in the DNA repair pathway is an effective way to induce synthetic lethality with chemotherapy or radiotherapy in cancer therapeutics. This study reviews the general pathways involved in DNA repair in cancer cells and the potential proteins that could be targeted for cancer therapeutics.https://www.mdpi.com/1422-0067/24/5/4741DNA damagecancer therapeuticsmutations |
| spellingShingle | Jaeyoung Moon Ichiwa Kitty Kusuma Renata Sisi Qin Fei Zhao Wootae Kim DNA Damage and Its Role in Cancer Therapeutics International Journal of Molecular Sciences DNA damage cancer therapeutics mutations |
| title | DNA Damage and Its Role in Cancer Therapeutics |
| title_full | DNA Damage and Its Role in Cancer Therapeutics |
| title_fullStr | DNA Damage and Its Role in Cancer Therapeutics |
| title_full_unstemmed | DNA Damage and Its Role in Cancer Therapeutics |
| title_short | DNA Damage and Its Role in Cancer Therapeutics |
| title_sort | dna damage and its role in cancer therapeutics |
| topic | DNA damage cancer therapeutics mutations |
| url | https://www.mdpi.com/1422-0067/24/5/4741 |
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