Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry
Abstract Background Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-12-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43055-022-00943-5 |
| _version_ | 1798005419540480000 |
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| author | Bassant Mahmoud Dawoud Abdelmonem Nooman Darweesh Mohamed Mohamed Hefeda Rasha Mohamed Kamal Rasha Lotfy Younis |
| author_facet | Bassant Mahmoud Dawoud Abdelmonem Nooman Darweesh Mohamed Mohamed Hefeda Rasha Mohamed Kamal Rasha Lotfy Younis |
| author_sort | Bassant Mahmoud Dawoud |
| collection | DOAJ |
| description | Abstract Background Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15–30% of breast tumors. The purpose of our study was to assess the role of contrast-enhanced mammography (CEM) in distinction between benign and malignant asymmetries. Results Out of the studied 540 indeterminate and suspicious asymmetries, and according to final histopathological results, 97/540 (17.9%) asymmetries were benign, 395/540(73%) asymmetries were malignant, 48/540 (8.9%) asymmetries were normal with no underlying pathology. After comparing results of sonomammography and CEM, CEM showed higher sensitivity (96.5% vs. 85.8), specificity (77.1% vs. 64.4%), NPV (88.8% vs. 62.7%), PPV (92.04% vs. 86.7%) and accuracy (91.3% vs. 80%). Conclusions CEM has proven to be a valuable and beneficial imaging technicality for patients and radiologists, with breast cancer detection sensitivities superior to that of full-field digital mammography (FFDM) with ultrasonography (US). |
| first_indexed | 2024-04-11T12:39:04Z |
| format | Article |
| id | doaj.art-9a550acc11ee4d63b97f84089dce0c3e |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-04-11T12:39:04Z |
| publishDate | 2022-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-9a550acc11ee4d63b97f84089dce0c3e2022-12-22T04:23:33ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622022-12-0153111310.1186/s43055-022-00943-5Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetryBassant Mahmoud Dawoud0Abdelmonem Nooman Darweesh1Mohamed Mohamed Hefeda2Rasha Mohamed Kamal3Rasha Lotfy Younis4Faculty of Medicine, Tanta UniversityFaculty of Medicine, Tanta UniversityFaculty of Medicine, Tanta UniversityFaculty of Medicine, Cairo UniversityFaculty of Medicine, Tanta UniversityAbstract Background Breast asymmetry is a prevalent mammographic finding described in BI-RADS atlas as asymmetry, focal asymmetry, global asymmetry, and developing asymmetry. Mammography has a limited role in discrimination between benign and malignant asymmetry, and digital mammography can overlook up to 15–30% of breast tumors. The purpose of our study was to assess the role of contrast-enhanced mammography (CEM) in distinction between benign and malignant asymmetries. Results Out of the studied 540 indeterminate and suspicious asymmetries, and according to final histopathological results, 97/540 (17.9%) asymmetries were benign, 395/540(73%) asymmetries were malignant, 48/540 (8.9%) asymmetries were normal with no underlying pathology. After comparing results of sonomammography and CEM, CEM showed higher sensitivity (96.5% vs. 85.8), specificity (77.1% vs. 64.4%), NPV (88.8% vs. 62.7%), PPV (92.04% vs. 86.7%) and accuracy (91.3% vs. 80%). Conclusions CEM has proven to be a valuable and beneficial imaging technicality for patients and radiologists, with breast cancer detection sensitivities superior to that of full-field digital mammography (FFDM) with ultrasonography (US).https://doi.org/10.1186/s43055-022-00943-5AsymmetryBreast cancerContrast-enhanced mammography (CEM)Mammography |
| spellingShingle | Bassant Mahmoud Dawoud Abdelmonem Nooman Darweesh Mohamed Mohamed Hefeda Rasha Mohamed Kamal Rasha Lotfy Younis Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry The Egyptian Journal of Radiology and Nuclear Medicine Asymmetry Breast cancer Contrast-enhanced mammography (CEM) Mammography |
| title | Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry |
| title_full | Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry |
| title_fullStr | Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry |
| title_full_unstemmed | Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry |
| title_short | Diagnostic value of contrast-enhanced mammography in the characterization of breast asymmetry |
| title_sort | diagnostic value of contrast enhanced mammography in the characterization of breast asymmetry |
| topic | Asymmetry Breast cancer Contrast-enhanced mammography (CEM) Mammography |
| url | https://doi.org/10.1186/s43055-022-00943-5 |
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