Expression of the gonadotropin receptors during follicular development
Abstract Background Gonadotropins induce follicular development that leads to ovulation and luteinization. In women, the level of gonadotropins, along with the expression of their receptors, changes dynamically throughout the menstrual cycle. This study aimed to clarify the mechanisms underlying the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Reproductive Medicine and Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rmb2.12075 |
| _version_ | 1818501786698252288 |
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| author | Hiroshi Kishi Yoshikazu Kitahara Fumiharu Imai Kohshiro Nakao Hiroto Suwa |
| author_facet | Hiroshi Kishi Yoshikazu Kitahara Fumiharu Imai Kohshiro Nakao Hiroto Suwa |
| author_sort | Hiroshi Kishi |
| collection | DOAJ |
| description | Abstract Background Gonadotropins induce follicular development that leads to ovulation and luteinization. In women, the level of gonadotropins, along with the expression of their receptors, changes dynamically throughout the menstrual cycle. This study aimed to clarify the mechanisms underlying these phenomena. Methods The literature was reviewed, including that published by the authors. Main findings (Results) Follicle‐stimulating hormone receptor expression in the granulosa cells was induced by androgens that were derived from growth differentiation factor‐9‐stimulated theca cells. In the theca cells, luteinizing hormone receptor (LHR) expression was noted from their appearance. In the granulosa cells, follicle‐stimulating hormone (FSH) stimulation was essential for LHR expression. However, FSH alone was not sufficient to respond to the luteinizing hormone (LH) surge for oocyte maturation, ovulation, and subsequent luteinization. To achieve these stages, various local factors that were derived from the granulosa and theca cells in response to FSH and LH stimulation had to work synergistically in an autocrine/paracrine manner to strongly induce LHR expression. Following the LH surge, the LHR expression decreased markedly; miRNAs were involved in this transient LHR downregulation. Following ovulation, LHR expression drastically increased again toward luteinization. Conclusion The expression of gonadotropin receptors is controlled by sophisticated and complicated systems; a breakdown of this system could lead to ovulation disorders. |
| first_indexed | 2024-12-10T21:01:01Z |
| format | Article |
| id | doaj.art-9a558849d76e4a459a3476cdff372630 |
| institution | Directory Open Access Journal |
| issn | 1445-5781 1447-0578 |
| language | English |
| last_indexed | 2024-12-10T21:01:01Z |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj.art-9a558849d76e4a459a3476cdff3726302022-12-22T01:33:49ZengWileyReproductive Medicine and Biology1445-57811447-05782018-01-01171111910.1002/rmb2.12075Expression of the gonadotropin receptors during follicular developmentHiroshi Kishi0Yoshikazu Kitahara1Fumiharu Imai2Kohshiro Nakao3Hiroto Suwa4Department of Obstetrics and Gynecology Gunma University Hospital Gunma JapanDepartment of Obstetrics and Gynecology Gunma University Hospital Gunma JapanDepartment of Obstetrics and Gynecology Gunma University Hospital Gunma JapanDepartment of Obstetrics and Gynecology Gunma University Hospital Gunma JapanDepartment of Obstetrics and Gynecology Gunma University Hospital Gunma JapanAbstract Background Gonadotropins induce follicular development that leads to ovulation and luteinization. In women, the level of gonadotropins, along with the expression of their receptors, changes dynamically throughout the menstrual cycle. This study aimed to clarify the mechanisms underlying these phenomena. Methods The literature was reviewed, including that published by the authors. Main findings (Results) Follicle‐stimulating hormone receptor expression in the granulosa cells was induced by androgens that were derived from growth differentiation factor‐9‐stimulated theca cells. In the theca cells, luteinizing hormone receptor (LHR) expression was noted from their appearance. In the granulosa cells, follicle‐stimulating hormone (FSH) stimulation was essential for LHR expression. However, FSH alone was not sufficient to respond to the luteinizing hormone (LH) surge for oocyte maturation, ovulation, and subsequent luteinization. To achieve these stages, various local factors that were derived from the granulosa and theca cells in response to FSH and LH stimulation had to work synergistically in an autocrine/paracrine manner to strongly induce LHR expression. Following the LH surge, the LHR expression decreased markedly; miRNAs were involved in this transient LHR downregulation. Following ovulation, LHR expression drastically increased again toward luteinization. Conclusion The expression of gonadotropin receptors is controlled by sophisticated and complicated systems; a breakdown of this system could lead to ovulation disorders.https://doi.org/10.1002/rmb2.12075follicle‐stimulating hormone receptorgranulosa cellsluteinizing hormone receptorreceptor downregulationtheca cells |
| spellingShingle | Hiroshi Kishi Yoshikazu Kitahara Fumiharu Imai Kohshiro Nakao Hiroto Suwa Expression of the gonadotropin receptors during follicular development Reproductive Medicine and Biology follicle‐stimulating hormone receptor granulosa cells luteinizing hormone receptor receptor downregulation theca cells |
| title | Expression of the gonadotropin receptors during follicular development |
| title_full | Expression of the gonadotropin receptors during follicular development |
| title_fullStr | Expression of the gonadotropin receptors during follicular development |
| title_full_unstemmed | Expression of the gonadotropin receptors during follicular development |
| title_short | Expression of the gonadotropin receptors during follicular development |
| title_sort | expression of the gonadotropin receptors during follicular development |
| topic | follicle‐stimulating hormone receptor granulosa cells luteinizing hormone receptor receptor downregulation theca cells |
| url | https://doi.org/10.1002/rmb2.12075 |
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