Application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders
IntroductionPseudocontinuous Arterial Spin Labeling (pCASL) perfusion imaging allows non-invasive quantification of regional cerebral blood flow (CBF) as part of a multimodal magnetic resonance imaging (MRI) protocol. This study aimed to compare regional CBF in autism spectrum disorders (ASD) indivi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.1045585/full |
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| author | Fang Ye Lei Du Lei Du Bing Liu Bing Liu Xinying Gao Aocai Yang Aocai Yang Die Liu Yue Chen Yue Chen Kuan Lv Kuan Lv Pengfei Xu Yuanmei Chen Jing Liu Jing Liu Lipeng Zhang Lipeng Zhang Shijun Li Amir Shmuel Amir Shmuel Qi Zhang Guolin Ma |
| author_facet | Fang Ye Lei Du Lei Du Bing Liu Bing Liu Xinying Gao Aocai Yang Aocai Yang Die Liu Yue Chen Yue Chen Kuan Lv Kuan Lv Pengfei Xu Yuanmei Chen Jing Liu Jing Liu Lipeng Zhang Lipeng Zhang Shijun Li Amir Shmuel Amir Shmuel Qi Zhang Guolin Ma |
| author_sort | Fang Ye |
| collection | DOAJ |
| description | IntroductionPseudocontinuous Arterial Spin Labeling (pCASL) perfusion imaging allows non-invasive quantification of regional cerebral blood flow (CBF) as part of a multimodal magnetic resonance imaging (MRI) protocol. This study aimed to compare regional CBF in autism spectrum disorders (ASD) individuals with their age-matched typically developing (TD) children using pCASL perfusion imaging.Materials and methodsThis cross-sectional study enrolled 17 individuals with ASD and 13 TD children. All participants underwent pCASL examination on a 3.0 T MRI scanner. Children in two groups were assessed for clinical characteristics and developmental profiles using Autism Behavior Checklist (ABC) and Gesell development diagnosis scale (GDDS), respectively. We compared CBF in different cerebral regions of ASD and TD children. We also assessed the association between CBF and clinical characteristics/developmental profile.ResultsCompared with TD children, individuals with ASD demonstrated a reduction in CBF in the left frontal lobe, the bilateral parietal lobes, and the bilateral temporal lobes. Within the ASD group, CBF was significantly higher in the right parietal lobe than in the left side. Correlation analysis of behavior characteristics and CBF in different regions showed a positive correlation between body and object domain scores on the ABC and CBF of the bilateral occipital lobes, and separately, between language domain scores and CBF of the left frontal lobe. The score of the social and self-help domain was negatively correlated with the CBF of the left frontal lobe, the left parietal lobe, and the left temporal lobe.ConclusionCerebral blood flow was found to be negatively correlated with scores in the social and self-help domain, and positively correlated with those in the body and object domain, indicating that CBF values are a potential MRI-based biomarker of disease severity in ASD patients. The findings may provide novel insight into the pathophysiological mechanisms of ASD. |
| first_indexed | 2024-04-11T07:13:34Z |
| format | Article |
| id | doaj.art-9a578e1d323740dbb0a19ac49165869b |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-11T07:13:34Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-9a578e1d323740dbb0a19ac49165869b2022-12-22T04:38:04ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-11-011610.3389/fnins.2022.10455851045585Application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disordersFang Ye0Lei Du1Lei Du2Bing Liu3Bing Liu4Xinying Gao5Aocai Yang6Aocai Yang7Die Liu8Yue Chen9Yue Chen10Kuan Lv11Kuan Lv12Pengfei Xu13Yuanmei Chen14Jing Liu15Jing Liu16Lipeng Zhang17Lipeng Zhang18Shijun Li19Amir Shmuel20Amir Shmuel21Qi Zhang22Guolin Ma23Department of Pediatrics, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Radiology, China-Japan Friendship Hospital, Beijing, ChinaKey Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Radiology, Peking University, Cancer Hospital and Institute, Beijing, ChinaDepartment of Radiology, China-Japan Friendship Hospital, Beijing, ChinaGraduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Pediatrics, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Radiology, China-Japan Friendship Hospital, Beijing, ChinaGraduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Pediatrics, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Radiology, China-Japan Friendship Hospital, Beijing, ChinaPeking University China-Japan Friendship School of Clinical Medicine, Beijing, ChinaDepartment of Radiology, China-Japan Friendship Hospital, Beijing, ChinaPeking University China-Japan Friendship School of Clinical Medicine, Beijing, ChinaDepartment of Pediatrics, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Pediatrics, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Pediatrics, China-Japan Friendship Hospital, Beijing, ChinaGraduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Pediatrics, China-Japan Friendship Hospital, Beijing, ChinaGraduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Radiology, First Medical Center of Chinese PLA General Hospital, Beijing, ChinaMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, CanadaDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, CanadaDepartment of Pediatrics, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Radiology, China-Japan Friendship Hospital, Beijing, ChinaIntroductionPseudocontinuous Arterial Spin Labeling (pCASL) perfusion imaging allows non-invasive quantification of regional cerebral blood flow (CBF) as part of a multimodal magnetic resonance imaging (MRI) protocol. This study aimed to compare regional CBF in autism spectrum disorders (ASD) individuals with their age-matched typically developing (TD) children using pCASL perfusion imaging.Materials and methodsThis cross-sectional study enrolled 17 individuals with ASD and 13 TD children. All participants underwent pCASL examination on a 3.0 T MRI scanner. Children in two groups were assessed for clinical characteristics and developmental profiles using Autism Behavior Checklist (ABC) and Gesell development diagnosis scale (GDDS), respectively. We compared CBF in different cerebral regions of ASD and TD children. We also assessed the association between CBF and clinical characteristics/developmental profile.ResultsCompared with TD children, individuals with ASD demonstrated a reduction in CBF in the left frontal lobe, the bilateral parietal lobes, and the bilateral temporal lobes. Within the ASD group, CBF was significantly higher in the right parietal lobe than in the left side. Correlation analysis of behavior characteristics and CBF in different regions showed a positive correlation between body and object domain scores on the ABC and CBF of the bilateral occipital lobes, and separately, between language domain scores and CBF of the left frontal lobe. The score of the social and self-help domain was negatively correlated with the CBF of the left frontal lobe, the left parietal lobe, and the left temporal lobe.ConclusionCerebral blood flow was found to be negatively correlated with scores in the social and self-help domain, and positively correlated with those in the body and object domain, indicating that CBF values are a potential MRI-based biomarker of disease severity in ASD patients. The findings may provide novel insight into the pathophysiological mechanisms of ASD.https://www.frontiersin.org/articles/10.3389/fnins.2022.1045585/fullcerebral blood flowarterial spin labelingautism spectrum disordersmagnetic resonance imagingchildren |
| spellingShingle | Fang Ye Lei Du Lei Du Bing Liu Bing Liu Xinying Gao Aocai Yang Aocai Yang Die Liu Yue Chen Yue Chen Kuan Lv Kuan Lv Pengfei Xu Yuanmei Chen Jing Liu Jing Liu Lipeng Zhang Lipeng Zhang Shijun Li Amir Shmuel Amir Shmuel Qi Zhang Guolin Ma Application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders Frontiers in Neuroscience cerebral blood flow arterial spin labeling autism spectrum disorders magnetic resonance imaging children |
| title | Application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders |
| title_full | Application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders |
| title_fullStr | Application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders |
| title_full_unstemmed | Application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders |
| title_short | Application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders |
| title_sort | application of pseudocontinuous arterial spin labeling perfusion imaging in children with autism spectrum disorders |
| topic | cerebral blood flow arterial spin labeling autism spectrum disorders magnetic resonance imaging children |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.1045585/full |
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