Downregulation of polo-like kinase 4 in hepatocellular carcinoma associates with poor prognosis.

Downregulation of polo-like kinase 4 in hepatocellular carcinoma associates with poor prognosis.

Polo-like kinase 4 (PLK4), belonging to serine/threonine kinase family, is critical for centriole replication and cell cycle progression. PLK4 has been proposed as a tumor suppressor in hepatocellular carcinoma (HCC). However, its expression and significance in HCC have not been well studied. In the...

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Bibliographic Details
Main Authors: Lili Liu, Chris Zhiyi Zhang, Muyan Cai, Jia Fu, George Gong Chen, Jingping Yun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3400587?pdf=render

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