Downregulation of polo-like kinase 4 in hepatocellular carcinoma associates with poor prognosis.
Polo-like kinase 4 (PLK4), belonging to serine/threonine kinase family, is critical for centriole replication and cell cycle progression. PLK4 has been proposed as a tumor suppressor in hepatocellular carcinoma (HCC). However, its expression and significance in HCC have not been well studied. In the...
Main Authors: | Lili Liu, Chris Zhiyi Zhang, Muyan Cai, Jia Fu, George Gong Chen, Jingping Yun |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3400587?pdf=render |
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