Association of <it>ADHIB </it>and <it>ALDH2 </it>gene polymorphisms with alcohol dependence: A pilot study from India
<p>Abstract</p> <p>Functional polymorphism in the genes encoding alcohol dehydrogenase (ADH) 1B and aldehyde dehydrogenase (ALDH) 2 are considered most important among several genetic determinants of alcohol dependence, a complex disorder. There is no report on the widely studied A...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-04-01
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| Series: | Human Genomics |
| Subjects: | |
| Online Access: | http://www.humgenomics.com/content/3/3/213 |
| _version_ | 1817990990704672768 |
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| author | Vaswani Meera Prasad Pushplata Kapur Suman |
| author_facet | Vaswani Meera Prasad Pushplata Kapur Suman |
| author_sort | Vaswani Meera |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Functional polymorphism in the genes encoding alcohol dehydrogenase (ADH) 1B and aldehyde dehydrogenase (ALDH) 2 are considered most important among several genetic determinants of alcohol dependence, a complex disorder. There is no report on the widely studied Arg47His and Glu487Lys polymorphisms from Indian alcoholdependent populations. In this paper, we report, for the first time, allelic and genotypic frequencies of Arg47His and Glu487Lys single nucleotide polymorphisms (SNPs) in North Indian alcohol-dependent subjects. A total of 174 alcohol-dependent males, recruited using DSM IV criteria (American Psychiatric Association, 1994), were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. The results obtained from genetic analysis were correlated with clinical parameters using Student's t-test or Mann Whitney's U test. The highlight of the study findings was the uniquely high frequency of the <it>ALDH2*2/*2 </it>genotype (among alcohol-dependent subjects) being a risk-conferring factor for alcohol dependence.</p> |
| first_indexed | 2024-04-14T01:07:28Z |
| format | Article |
| id | doaj.art-9a57be2196d946b48c6774eff056a938 |
| institution | Directory Open Access Journal |
| issn | 1479-7364 |
| language | English |
| last_indexed | 2024-04-14T01:07:28Z |
| publishDate | 2009-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Human Genomics |
| spelling | doaj.art-9a57be2196d946b48c6774eff056a9382022-12-22T02:21:11ZengBMCHuman Genomics1479-73642009-04-013321322010.1186/1479-7364-3-3-213Association of <it>ADHIB </it>and <it>ALDH2 </it>gene polymorphisms with alcohol dependence: A pilot study from IndiaVaswani MeeraPrasad PushplataKapur Suman<p>Abstract</p> <p>Functional polymorphism in the genes encoding alcohol dehydrogenase (ADH) 1B and aldehyde dehydrogenase (ALDH) 2 are considered most important among several genetic determinants of alcohol dependence, a complex disorder. There is no report on the widely studied Arg47His and Glu487Lys polymorphisms from Indian alcoholdependent populations. In this paper, we report, for the first time, allelic and genotypic frequencies of Arg47His and Glu487Lys single nucleotide polymorphisms (SNPs) in North Indian alcohol-dependent subjects. A total of 174 alcohol-dependent males, recruited using DSM IV criteria (American Psychiatric Association, 1994), were genotyped using the polymerase chain reaction-restriction fragment length polymorphism method. The results obtained from genetic analysis were correlated with clinical parameters using Student's t-test or Mann Whitney's U test. The highlight of the study findings was the uniquely high frequency of the <it>ALDH2*2/*2 </it>genotype (among alcohol-dependent subjects) being a risk-conferring factor for alcohol dependence.</p>http://www.humgenomics.com/content/3/3/213alcohol dependencealcohol dehydrogenasealdehyde dehydrogenasegenotype-phenotype correlation |
| spellingShingle | Vaswani Meera Prasad Pushplata Kapur Suman Association of <it>ADHIB </it>and <it>ALDH2 </it>gene polymorphisms with alcohol dependence: A pilot study from India Human Genomics alcohol dependence alcohol dehydrogenase aldehyde dehydrogenase genotype-phenotype correlation |
| title | Association of <it>ADHIB </it>and <it>ALDH2 </it>gene polymorphisms with alcohol dependence: A pilot study from India |
| title_full | Association of <it>ADHIB </it>and <it>ALDH2 </it>gene polymorphisms with alcohol dependence: A pilot study from India |
| title_fullStr | Association of <it>ADHIB </it>and <it>ALDH2 </it>gene polymorphisms with alcohol dependence: A pilot study from India |
| title_full_unstemmed | Association of <it>ADHIB </it>and <it>ALDH2 </it>gene polymorphisms with alcohol dependence: A pilot study from India |
| title_short | Association of <it>ADHIB </it>and <it>ALDH2 </it>gene polymorphisms with alcohol dependence: A pilot study from India |
| title_sort | association of it adhib it and it aldh2 it gene polymorphisms with alcohol dependence a pilot study from india |
| topic | alcohol dependence alcohol dehydrogenase aldehyde dehydrogenase genotype-phenotype correlation |
| url | http://www.humgenomics.com/content/3/3/213 |
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