Controlled-release of indomethacin trigged by inflammation-response for wound care
An inflammatory-responsive intelligent controlled-release drug-loaded membrane (polycaprolactone/poly (hydroxyethyl methacrylate hydroxyethyl-methacrylate -2-(2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol -3-yl) acetoxy) ethyl meth acylate) PCL/P(HEMA-HEIn) was prepared. Drug precursors HEIn wa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-05-01
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| Series: | Polymer Testing |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0142941821000799 |
| _version_ | 1818720666100170752 |
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| author | Yanping Huang Ye Dan Nianhua Dan Yining Chen |
| author_facet | Yanping Huang Ye Dan Nianhua Dan Yining Chen |
| author_sort | Yanping Huang |
| collection | DOAJ |
| description | An inflammatory-responsive intelligent controlled-release drug-loaded membrane (polycaprolactone/poly (hydroxyethyl methacrylate hydroxyethyl-methacrylate -2-(2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol -3-yl) acetoxy) ethyl meth acylate) PCL/P(HEMA-HEIn) was prepared. Drug precursors HEIn was synthesized by the esterification reaction between indomethacin (Indo) and hydroxyethyl methacrylate (HEMA) and the structure of HEIn was confirmed by 13C NMR and ESI-MS. Through in-situ crosslinking polymerization and solvent evaporation, the drug-loaded membranes were fabricated. Furthermore, the morphology, chemical and physical properties demonstrated that HEIn and HEMA were copolymerized and well dispersed in the film. The drug released from PCL/P(HEME-HEIn) could be triggered by inflammation environment and the release amount increased along with the degree of inflammation. Results of in vivo evaluation proved that the PCL/P(HEME-HEIn) film had the capacity of inhibiting inflammation, which was beneficial to wound healing. The proposed strategy towards PCL/P(HEME-HEIn) opened new window for drug controlled-releasing via inflammatory response. |
| first_indexed | 2024-12-17T20:26:27Z |
| format | Article |
| id | doaj.art-9a58006532d94244ac902bce0a56524b |
| institution | Directory Open Access Journal |
| issn | 0142-9418 |
| language | English |
| last_indexed | 2024-12-17T20:26:27Z |
| publishDate | 2021-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Polymer Testing |
| spelling | doaj.art-9a58006532d94244ac902bce0a56524b2022-12-21T21:33:46ZengElsevierPolymer Testing0142-94182021-05-0197107129Controlled-release of indomethacin trigged by inflammation-response for wound careYanping Huang0Ye Dan1Nianhua Dan2Yining Chen3Center of Engineering Experimental Teaching, School of Chemical Engineering, Sichuan University, Chengdu, 610065, ChinaSchool of Mechanical Engineering, Sichuan University, Chengdu, 610065, ChinaCollege of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China; Corresponding author.College of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China; Corresponding author.An inflammatory-responsive intelligent controlled-release drug-loaded membrane (polycaprolactone/poly (hydroxyethyl methacrylate hydroxyethyl-methacrylate -2-(2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol -3-yl) acetoxy) ethyl meth acylate) PCL/P(HEMA-HEIn) was prepared. Drug precursors HEIn was synthesized by the esterification reaction between indomethacin (Indo) and hydroxyethyl methacrylate (HEMA) and the structure of HEIn was confirmed by 13C NMR and ESI-MS. Through in-situ crosslinking polymerization and solvent evaporation, the drug-loaded membranes were fabricated. Furthermore, the morphology, chemical and physical properties demonstrated that HEIn and HEMA were copolymerized and well dispersed in the film. The drug released from PCL/P(HEME-HEIn) could be triggered by inflammation environment and the release amount increased along with the degree of inflammation. Results of in vivo evaluation proved that the PCL/P(HEME-HEIn) film had the capacity of inhibiting inflammation, which was beneficial to wound healing. The proposed strategy towards PCL/P(HEME-HEIn) opened new window for drug controlled-releasing via inflammatory response.http://www.sciencedirect.com/science/article/pii/S0142941821000799Inflammatory-responsiveControlled-releasingIn-situ crosslinking polymerizationWound care |
| spellingShingle | Yanping Huang Ye Dan Nianhua Dan Yining Chen Controlled-release of indomethacin trigged by inflammation-response for wound care Polymer Testing Inflammatory-responsive Controlled-releasing In-situ crosslinking polymerization Wound care |
| title | Controlled-release of indomethacin trigged by inflammation-response for wound care |
| title_full | Controlled-release of indomethacin trigged by inflammation-response for wound care |
| title_fullStr | Controlled-release of indomethacin trigged by inflammation-response for wound care |
| title_full_unstemmed | Controlled-release of indomethacin trigged by inflammation-response for wound care |
| title_short | Controlled-release of indomethacin trigged by inflammation-response for wound care |
| title_sort | controlled release of indomethacin trigged by inflammation response for wound care |
| topic | Inflammatory-responsive Controlled-releasing In-situ crosslinking polymerization Wound care |
| url | http://www.sciencedirect.com/science/article/pii/S0142941821000799 |
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