Subcutaneous Fat Necrosis and Hypercalcemia with Nephrocalcinosis in Infancy: Case Report and Review of the Literature
Subcutaneous fat necrosis is an uncommon benign panniculitis affecting more commonly full-term newborns. It has been associated with birth asphyxia and meconium aspiration, as well as therapeutic hypothermia. Although the prognosis is generally favorable, complications such as hypercalcemia, thrombo...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | Children |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9067/8/5/374 |
| _version_ | 1827693077084504064 |
|---|---|
| author | Katerina Chrysaidou Georgios Sargiotis Vasiliki Karava Dimitrios Liasis Victor Gourvas Vissarios Moutsanas Athanasios Christoforidis Stella Stabouli |
| author_facet | Katerina Chrysaidou Georgios Sargiotis Vasiliki Karava Dimitrios Liasis Victor Gourvas Vissarios Moutsanas Athanasios Christoforidis Stella Stabouli |
| author_sort | Katerina Chrysaidou |
| collection | DOAJ |
| description | Subcutaneous fat necrosis is an uncommon benign panniculitis affecting more commonly full-term newborns. It has been associated with birth asphyxia and meconium aspiration, as well as therapeutic hypothermia. Although the prognosis is generally favorable, complications such as hypercalcemia, thrombocytopenia, hypoglycemia and hypertriglyceridemia may complicate its course. The most serious complication is hypercalcemia that may reach life threatening levels and can be associated with nephrocalcinosis. We thereby describe a case of subcutaneous fat necrosis after therapeutic hypothermia, which presented with late-onset refractory severe hypercalcemia and persistent nephrocalcinosis during the follow up of the patient. Due to the risk of the development of chronic kidney disease, we highlight the importance of careful monitoring of hypercalcemia and review the literature of subcutaneous fat necrosis related to nephrocalcinosis. |
| first_indexed | 2024-03-10T11:35:49Z |
| format | Article |
| id | doaj.art-9a5814f5590341dbbf951803b8769c42 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T11:35:49Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-9a5814f5590341dbbf951803b8769c422023-11-21T18:54:43ZengMDPI AGChildren2227-90672021-05-018537410.3390/children8050374Subcutaneous Fat Necrosis and Hypercalcemia with Nephrocalcinosis in Infancy: Case Report and Review of the LiteratureKaterina Chrysaidou0Georgios Sargiotis1Vasiliki Karava2Dimitrios Liasis3Victor Gourvas4Vissarios Moutsanas5Athanasios Christoforidis6Stella Stabouli71st Department of Pediatrics, Aristotle University of Thessaloniki, Hippokratio General Hospital Thessaloniki, 54642 Thessaloniki, Greece1st Department of Pediatrics, Aristotle University of Thessaloniki, Hippokratio General Hospital Thessaloniki, 54642 Thessaloniki, Greece1st Department of Pediatrics, Aristotle University of Thessaloniki, Hippokratio General Hospital Thessaloniki, 54642 Thessaloniki, GreeceDepartment of Pediatrics, St Luke’s Hospital, Panorama, 55236 Thessaloniki, GreeceDepartment of Pediatrics, St Luke’s Hospital, Panorama, 55236 Thessaloniki, GreecePediatric Department, G. Gennimatas Hospital, 54635 Thessaloniki, Greece1st Department of Pediatrics, Aristotle University of Thessaloniki, Hippokratio General Hospital Thessaloniki, 54642 Thessaloniki, Greece1st Department of Pediatrics, Aristotle University of Thessaloniki, Hippokratio General Hospital Thessaloniki, 54642 Thessaloniki, GreeceSubcutaneous fat necrosis is an uncommon benign panniculitis affecting more commonly full-term newborns. It has been associated with birth asphyxia and meconium aspiration, as well as therapeutic hypothermia. Although the prognosis is generally favorable, complications such as hypercalcemia, thrombocytopenia, hypoglycemia and hypertriglyceridemia may complicate its course. The most serious complication is hypercalcemia that may reach life threatening levels and can be associated with nephrocalcinosis. We thereby describe a case of subcutaneous fat necrosis after therapeutic hypothermia, which presented with late-onset refractory severe hypercalcemia and persistent nephrocalcinosis during the follow up of the patient. Due to the risk of the development of chronic kidney disease, we highlight the importance of careful monitoring of hypercalcemia and review the literature of subcutaneous fat necrosis related to nephrocalcinosis.https://www.mdpi.com/2227-9067/8/5/374subcutaneous fatfat necrosishypercalcemianewbornnephrocalcinosis |
| spellingShingle | Katerina Chrysaidou Georgios Sargiotis Vasiliki Karava Dimitrios Liasis Victor Gourvas Vissarios Moutsanas Athanasios Christoforidis Stella Stabouli Subcutaneous Fat Necrosis and Hypercalcemia with Nephrocalcinosis in Infancy: Case Report and Review of the Literature Children subcutaneous fat fat necrosis hypercalcemia newborn nephrocalcinosis |
| title | Subcutaneous Fat Necrosis and Hypercalcemia with Nephrocalcinosis in Infancy: Case Report and Review of the Literature |
| title_full | Subcutaneous Fat Necrosis and Hypercalcemia with Nephrocalcinosis in Infancy: Case Report and Review of the Literature |
| title_fullStr | Subcutaneous Fat Necrosis and Hypercalcemia with Nephrocalcinosis in Infancy: Case Report and Review of the Literature |
| title_full_unstemmed | Subcutaneous Fat Necrosis and Hypercalcemia with Nephrocalcinosis in Infancy: Case Report and Review of the Literature |
| title_short | Subcutaneous Fat Necrosis and Hypercalcemia with Nephrocalcinosis in Infancy: Case Report and Review of the Literature |
| title_sort | subcutaneous fat necrosis and hypercalcemia with nephrocalcinosis in infancy case report and review of the literature |
| topic | subcutaneous fat fat necrosis hypercalcemia newborn nephrocalcinosis |
| url | https://www.mdpi.com/2227-9067/8/5/374 |
| work_keys_str_mv | AT katerinachrysaidou subcutaneousfatnecrosisandhypercalcemiawithnephrocalcinosisininfancycasereportandreviewoftheliterature AT georgiossargiotis subcutaneousfatnecrosisandhypercalcemiawithnephrocalcinosisininfancycasereportandreviewoftheliterature AT vasilikikarava subcutaneousfatnecrosisandhypercalcemiawithnephrocalcinosisininfancycasereportandreviewoftheliterature AT dimitriosliasis subcutaneousfatnecrosisandhypercalcemiawithnephrocalcinosisininfancycasereportandreviewoftheliterature AT victorgourvas subcutaneousfatnecrosisandhypercalcemiawithnephrocalcinosisininfancycasereportandreviewoftheliterature AT vissariosmoutsanas subcutaneousfatnecrosisandhypercalcemiawithnephrocalcinosisininfancycasereportandreviewoftheliterature AT athanasioschristoforidis subcutaneousfatnecrosisandhypercalcemiawithnephrocalcinosisininfancycasereportandreviewoftheliterature AT stellastabouli subcutaneousfatnecrosisandhypercalcemiawithnephrocalcinosisininfancycasereportandreviewoftheliterature |