Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity
Metabolic syndrome (MetS) is a precursor to the major health diseases associated with high mortality in industrialized countries: cardiovascular disease and diabetes. An important component of the pathogenesis of the metabolic syndrome is mitochondrial dysfunction, which is associated with tissue hy...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/15/12012 |
| _version_ | 1797586691426353152 |
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| author | Natalia Todosenko Olga Khaziakhmatova Vladimir Malashchenko Kristina Yurova Maria Bograya Maria Beletskaya Maria Vulf Natalia Gazatova Larisa Litvinova |
| author_facet | Natalia Todosenko Olga Khaziakhmatova Vladimir Malashchenko Kristina Yurova Maria Bograya Maria Beletskaya Maria Vulf Natalia Gazatova Larisa Litvinova |
| author_sort | Natalia Todosenko |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) is a precursor to the major health diseases associated with high mortality in industrialized countries: cardiovascular disease and diabetes. An important component of the pathogenesis of the metabolic syndrome is mitochondrial dysfunction, which is associated with tissue hypoxia, disruption of mitochondrial integrity, increased production of reactive oxygen species, and a decrease in ATP, leading to a chronic inflammatory state that affects tissues and organ systems. The mitochondrial AAA + protease Lon (Lonp1) has a broad spectrum of activities. In addition to its classical function (degradation of misfolded or damaged proteins), enzymatic activity (proteolysis, chaperone activity, mitochondrial DNA (mtDNA)binding) has been demonstrated. At the same time, the spectrum of Lonp1 activity extends to the regulation of cellular processes inside mitochondria, as well as outside mitochondria (nuclear localization). This mitochondrial protease with enzymatic activity may be a promising molecular target for the development of targeted therapy for MetS and its components. The aim of this review is to elucidate the role of mtDNA in the pathogenesis of metabolic syndrome and its components as a key component of mitochondrial dysfunction and to describe the promising and little-studied AAA + LonP1 protease as a potential target in metabolic disorders. |
| first_indexed | 2024-03-11T00:26:39Z |
| format | Article |
| id | doaj.art-9a5e5d87f18244418aaef4a89b84ae56 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T00:26:39Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9a5e5d87f18244418aaef4a89b84ae562023-11-18T22:59:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-07-0124151201210.3390/ijms241512012Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and ObesityNatalia Todosenko0Olga Khaziakhmatova1Vladimir Malashchenko2Kristina Yurova3Maria Bograya4Maria Beletskaya5Maria Vulf6Natalia Gazatova7Larisa Litvinova8Center for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaCenter for Immunology and Cellular Biotechnology, Immanuel Kant Baltic Federal University, 236001 Kaliningrad, RussiaMetabolic syndrome (MetS) is a precursor to the major health diseases associated with high mortality in industrialized countries: cardiovascular disease and diabetes. An important component of the pathogenesis of the metabolic syndrome is mitochondrial dysfunction, which is associated with tissue hypoxia, disruption of mitochondrial integrity, increased production of reactive oxygen species, and a decrease in ATP, leading to a chronic inflammatory state that affects tissues and organ systems. The mitochondrial AAA + protease Lon (Lonp1) has a broad spectrum of activities. In addition to its classical function (degradation of misfolded or damaged proteins), enzymatic activity (proteolysis, chaperone activity, mitochondrial DNA (mtDNA)binding) has been demonstrated. At the same time, the spectrum of Lonp1 activity extends to the regulation of cellular processes inside mitochondria, as well as outside mitochondria (nuclear localization). This mitochondrial protease with enzymatic activity may be a promising molecular target for the development of targeted therapy for MetS and its components. The aim of this review is to elucidate the role of mtDNA in the pathogenesis of metabolic syndrome and its components as a key component of mitochondrial dysfunction and to describe the promising and little-studied AAA + LonP1 protease as a potential target in metabolic disorders.https://www.mdpi.com/1422-0067/24/15/12012metabolic syndromeobesitymitochondrial dysfunctionmtDNAmitochondrial protease Lonp1 |
| spellingShingle | Natalia Todosenko Olga Khaziakhmatova Vladimir Malashchenko Kristina Yurova Maria Bograya Maria Beletskaya Maria Vulf Natalia Gazatova Larisa Litvinova Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity International Journal of Molecular Sciences metabolic syndrome obesity mitochondrial dysfunction mtDNA mitochondrial protease Lonp1 |
| title | Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity |
| title_full | Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity |
| title_fullStr | Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity |
| title_full_unstemmed | Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity |
| title_short | Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity |
| title_sort | mitochondrial dysfunction associated with mtdna in metabolic syndrome and obesity |
| topic | metabolic syndrome obesity mitochondrial dysfunction mtDNA mitochondrial protease Lonp1 |
| url | https://www.mdpi.com/1422-0067/24/15/12012 |
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