An alternative in situ gel-formulation of levofloxacin eye drops for prolong ocular retention
Introduction: Delivering drugs to ocular region is a challenging task. Eye physiological barriers lead to relatively less therapeutic and bioavailability effect by the conventional eye drops. This may be overcome by the use of in situ gel delivery system. Objective: The objective of our work was to...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-01-01
|
| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2015;volume=7;issue=1;spage=9;epage=14;aulast=Gupta |
| _version_ | 1811302934763274240 |
|---|---|
| author | Himanshu Gupta M Aqil R K Khar Asgar Ali Aseem Bhatnagar Gaurav Mittal |
| author_facet | Himanshu Gupta M Aqil R K Khar Asgar Ali Aseem Bhatnagar Gaurav Mittal |
| author_sort | Himanshu Gupta |
| collection | DOAJ |
| description | Introduction: Delivering drugs to ocular region is a challenging task. Eye physiological barriers lead to relatively less therapeutic and bioavailability effect by the conventional eye drops. This may be overcome by the use of in situ gel delivery system. Objective: The objective of our work was to formulate an ocular delivery system of levofloxacin, based on the concept of ion (sodium alginate) and pH (chitosan) activated in situ gelation concept. Due to its elastic properties, in situ gels resist the ocular drainage of drug leading to longer contact times with ocular surface. Materials and Methods: The formulation was evaluated for physicochemical characteristics, in vitro drug release. Ocular retention studies were carried out by Gamma scintigraphy. Time activity curve was plotted between marketed formulation and developed formulation for comparing drug drainage from the eye with time. Ocular tolerance test was performed by handheld infra-red camera. Results and Discussion: The formulations showed a first-order release pattern over 12 h. Both in vitro release studies and in vivo gamma scintigraphy precorneal retention studies indicated better therapeutic efficacy compared with standard eye drops. Conclusion: The results demonstrated that the developed in situ gel of levofloxacin is nonirritant, has prolonged action and is a better option in terms of retention, ocular bioavailability and patient compliance when compared with plain eye drops formulation. |
| first_indexed | 2024-04-13T07:38:12Z |
| format | Article |
| id | doaj.art-9a5eb9c3f3a641aa94beb7e05ba96bb8 |
| institution | Directory Open Access Journal |
| issn | 0975-7406 0976-4879 |
| language | English |
| last_indexed | 2024-04-13T07:38:12Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-9a5eb9c3f3a641aa94beb7e05ba96bb82022-12-22T02:56:00ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74060976-48792015-01-017191410.4103/0975-7406.149810An alternative in situ gel-formulation of levofloxacin eye drops for prolong ocular retentionHimanshu GuptaM AqilR K KharAsgar AliAseem BhatnagarGaurav MittalIntroduction: Delivering drugs to ocular region is a challenging task. Eye physiological barriers lead to relatively less therapeutic and bioavailability effect by the conventional eye drops. This may be overcome by the use of in situ gel delivery system. Objective: The objective of our work was to formulate an ocular delivery system of levofloxacin, based on the concept of ion (sodium alginate) and pH (chitosan) activated in situ gelation concept. Due to its elastic properties, in situ gels resist the ocular drainage of drug leading to longer contact times with ocular surface. Materials and Methods: The formulation was evaluated for physicochemical characteristics, in vitro drug release. Ocular retention studies were carried out by Gamma scintigraphy. Time activity curve was plotted between marketed formulation and developed formulation for comparing drug drainage from the eye with time. Ocular tolerance test was performed by handheld infra-red camera. Results and Discussion: The formulations showed a first-order release pattern over 12 h. Both in vitro release studies and in vivo gamma scintigraphy precorneal retention studies indicated better therapeutic efficacy compared with standard eye drops. Conclusion: The results demonstrated that the developed in situ gel of levofloxacin is nonirritant, has prolonged action and is a better option in terms of retention, ocular bioavailability and patient compliance when compared with plain eye drops formulation.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2015;volume=7;issue=1;spage=9;epage=14;aulast=GuptaChitosangamma scintigraphyin situ gellevofloxacinocular toleranceradiolabelling |
| spellingShingle | Himanshu Gupta M Aqil R K Khar Asgar Ali Aseem Bhatnagar Gaurav Mittal An alternative in situ gel-formulation of levofloxacin eye drops for prolong ocular retention Journal of Pharmacy and Bioallied Sciences Chitosan gamma scintigraphy in situ gel levofloxacin ocular tolerance radiolabelling |
| title | An alternative in situ gel-formulation of levofloxacin eye drops for prolong ocular retention |
| title_full | An alternative in situ gel-formulation of levofloxacin eye drops for prolong ocular retention |
| title_fullStr | An alternative in situ gel-formulation of levofloxacin eye drops for prolong ocular retention |
| title_full_unstemmed | An alternative in situ gel-formulation of levofloxacin eye drops for prolong ocular retention |
| title_short | An alternative in situ gel-formulation of levofloxacin eye drops for prolong ocular retention |
| title_sort | alternative in situ gel formulation of levofloxacin eye drops for prolong ocular retention |
| topic | Chitosan gamma scintigraphy in situ gel levofloxacin ocular tolerance radiolabelling |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2015;volume=7;issue=1;spage=9;epage=14;aulast=Gupta |
| work_keys_str_mv | AT himanshugupta analternativeinsitugelformulationoflevofloxacineyedropsforprolongocularretention AT maqil analternativeinsitugelformulationoflevofloxacineyedropsforprolongocularretention AT rkkhar analternativeinsitugelformulationoflevofloxacineyedropsforprolongocularretention AT asgarali analternativeinsitugelformulationoflevofloxacineyedropsforprolongocularretention AT aseembhatnagar analternativeinsitugelformulationoflevofloxacineyedropsforprolongocularretention AT gauravmittal analternativeinsitugelformulationoflevofloxacineyedropsforprolongocularretention AT himanshugupta alternativeinsitugelformulationoflevofloxacineyedropsforprolongocularretention AT maqil alternativeinsitugelformulationoflevofloxacineyedropsforprolongocularretention AT rkkhar alternativeinsitugelformulationoflevofloxacineyedropsforprolongocularretention AT asgarali alternativeinsitugelformulationoflevofloxacineyedropsforprolongocularretention AT aseembhatnagar alternativeinsitugelformulationoflevofloxacineyedropsforprolongocularretention AT gauravmittal alternativeinsitugelformulationoflevofloxacineyedropsforprolongocularretention |