The Relationship between Mitochondria and Neurodegeration in the Eye: A Review
Mitochondria are the energy factories of cells. Mitochondrial dysfunction directly affects the function and morphology of cells. In recent years, growing evidence has shown that mitochondrial dysfunction plays an important role in neurodegenerative diseases. In the eye, some age-related diseases are...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/16/7385 |
| _version_ | 1797524791450664960 |
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| author | Hongtao Liu Hanhan Liu Verena Prokosch |
| author_facet | Hongtao Liu Hanhan Liu Verena Prokosch |
| author_sort | Hongtao Liu |
| collection | DOAJ |
| description | Mitochondria are the energy factories of cells. Mitochondrial dysfunction directly affects the function and morphology of cells. In recent years, growing evidence has shown that mitochondrial dysfunction plays an important role in neurodegenerative diseases. In the eye, some age-related diseases are considered to be neurodegenerative diseases, such as primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD). Here, we review the mechanisms of mitochondrial damage, post-injury repair, and the roles of mitochondria in various tissues of the eye. In the following sections, the potential for treating glaucoma by reducing mitochondrial damage and promoting post-injury repair is also discussed. |
| first_indexed | 2024-03-10T09:02:35Z |
| format | Article |
| id | doaj.art-9a5f268e5e924a48acd8b7cadefe5941 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T09:02:35Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-9a5f268e5e924a48acd8b7cadefe59412023-11-22T06:40:50ZengMDPI AGApplied Sciences2076-34172021-08-011116738510.3390/app11167385The Relationship between Mitochondria and Neurodegeration in the Eye: A ReviewHongtao Liu0Hanhan Liu1Verena Prokosch2Department of Ophthalmology, Faculty of Medicine, University Hospital of Cologne, University of Cologne, 50937 Cologne, GermanyDepartment of Ophthalmology, Faculty of Medicine, University Hospital of Cologne, University of Cologne, 50937 Cologne, GermanyDepartment of Ophthalmology, Faculty of Medicine, University Hospital of Cologne, University of Cologne, 50937 Cologne, GermanyMitochondria are the energy factories of cells. Mitochondrial dysfunction directly affects the function and morphology of cells. In recent years, growing evidence has shown that mitochondrial dysfunction plays an important role in neurodegenerative diseases. In the eye, some age-related diseases are considered to be neurodegenerative diseases, such as primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD). Here, we review the mechanisms of mitochondrial damage, post-injury repair, and the roles of mitochondria in various tissues of the eye. In the following sections, the potential for treating glaucoma by reducing mitochondrial damage and promoting post-injury repair is also discussed.https://www.mdpi.com/2076-3417/11/16/7385mitochondrialROSneurodegenerationglaucoma |
| spellingShingle | Hongtao Liu Hanhan Liu Verena Prokosch The Relationship between Mitochondria and Neurodegeration in the Eye: A Review Applied Sciences mitochondrial ROS neurodegeneration glaucoma |
| title | The Relationship between Mitochondria and Neurodegeration in the Eye: A Review |
| title_full | The Relationship between Mitochondria and Neurodegeration in the Eye: A Review |
| title_fullStr | The Relationship between Mitochondria and Neurodegeration in the Eye: A Review |
| title_full_unstemmed | The Relationship between Mitochondria and Neurodegeration in the Eye: A Review |
| title_short | The Relationship between Mitochondria and Neurodegeration in the Eye: A Review |
| title_sort | relationship between mitochondria and neurodegeration in the eye a review |
| topic | mitochondrial ROS neurodegeneration glaucoma |
| url | https://www.mdpi.com/2076-3417/11/16/7385 |
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