Advances in Intraoperative Glioma Tissue Sampling and Infiltration Assessment
Gliomas are infiltrative brain tumors that often involve functional tissue. While maximal safe resection is critical for maximizing survival, this is challenged by the difficult intraoperative discrimination between tumor-infiltrated and normal structures. Surgical expertise is essential for identif...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
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| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/13/12/1637 |
| _version_ | 1797381816354603008 |
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| author | Nadeem N. Al-Adli Jacob S. Young Katie Scotford Youssef E. Sibih Jessica Payne Mitchel S. Berger |
| author_facet | Nadeem N. Al-Adli Jacob S. Young Katie Scotford Youssef E. Sibih Jessica Payne Mitchel S. Berger |
| author_sort | Nadeem N. Al-Adli |
| collection | DOAJ |
| description | Gliomas are infiltrative brain tumors that often involve functional tissue. While maximal safe resection is critical for maximizing survival, this is challenged by the difficult intraoperative discrimination between tumor-infiltrated and normal structures. Surgical expertise is essential for identifying safe margins, and while the intraoperative pathological review of frozen tissue is possible, this is a time-consuming task. Advances in intraoperative stimulation mapping have aided surgeons in identifying functional structures and, as such, has become the gold standard for this purpose. However, intraoperative margin assessment lacks a similar consensus. Nonetheless, recent advances in intraoperative imaging techniques and tissue examination methods have demonstrated promise for the accurate and efficient assessment of tumor infiltration and margin delineation within the operating room, respectively. In this review, we describe these innovative technologies that neurosurgeons should be aware of. |
| first_indexed | 2024-03-08T20:56:57Z |
| format | Article |
| id | doaj.art-9a5fbe50cb464c0ea63882bea1e5e179 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-08T20:56:57Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-9a5fbe50cb464c0ea63882bea1e5e1792023-12-22T13:56:57ZengMDPI AGBrain Sciences2076-34252023-11-011312163710.3390/brainsci13121637Advances in Intraoperative Glioma Tissue Sampling and Infiltration AssessmentNadeem N. Al-Adli0Jacob S. Young1Katie Scotford2Youssef E. Sibih3Jessica Payne4Mitchel S. Berger5Department of Neurosurgery, University of California San Francisco, San Francisco, CA 94131, USADepartment of Neurosurgery, University of California San Francisco, San Francisco, CA 94131, USADepartment of Neurosurgery, University of California San Francisco, San Francisco, CA 94131, USASchool of Medicine, University of California San Francisco, San Francisco, CA 94131, USADepartment of Neurosurgery, University of California San Francisco, San Francisco, CA 94131, USADepartment of Neurosurgery, University of California San Francisco, San Francisco, CA 94131, USAGliomas are infiltrative brain tumors that often involve functional tissue. While maximal safe resection is critical for maximizing survival, this is challenged by the difficult intraoperative discrimination between tumor-infiltrated and normal structures. Surgical expertise is essential for identifying safe margins, and while the intraoperative pathological review of frozen tissue is possible, this is a time-consuming task. Advances in intraoperative stimulation mapping have aided surgeons in identifying functional structures and, as such, has become the gold standard for this purpose. However, intraoperative margin assessment lacks a similar consensus. Nonetheless, recent advances in intraoperative imaging techniques and tissue examination methods have demonstrated promise for the accurate and efficient assessment of tumor infiltration and margin delineation within the operating room, respectively. In this review, we describe these innovative technologies that neurosurgeons should be aware of.https://www.mdpi.com/2076-3425/13/12/1637intraoperative marginsintraoperative imagingtumor marginsgliomaextent of resectionadvanced tissue sampling |
| spellingShingle | Nadeem N. Al-Adli Jacob S. Young Katie Scotford Youssef E. Sibih Jessica Payne Mitchel S. Berger Advances in Intraoperative Glioma Tissue Sampling and Infiltration Assessment Brain Sciences intraoperative margins intraoperative imaging tumor margins glioma extent of resection advanced tissue sampling |
| title | Advances in Intraoperative Glioma Tissue Sampling and Infiltration Assessment |
| title_full | Advances in Intraoperative Glioma Tissue Sampling and Infiltration Assessment |
| title_fullStr | Advances in Intraoperative Glioma Tissue Sampling and Infiltration Assessment |
| title_full_unstemmed | Advances in Intraoperative Glioma Tissue Sampling and Infiltration Assessment |
| title_short | Advances in Intraoperative Glioma Tissue Sampling and Infiltration Assessment |
| title_sort | advances in intraoperative glioma tissue sampling and infiltration assessment |
| topic | intraoperative margins intraoperative imaging tumor margins glioma extent of resection advanced tissue sampling |
| url | https://www.mdpi.com/2076-3425/13/12/1637 |
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