Dihydromyricetin Modulates Nrf2 and NF-κB Crosstalk to Alleviate Methotrexate-Induced Lung Toxicity

Dihydromyricetin Modulates Nrf2 and NF-κB Crosstalk to Alleviate Methotrexate-Induced Lung Toxicity

Background: Methotrexate (MTX) is an effective anticancer, anti-inflammatory, and immunomodulatory agent. However, it induces a serious pneumonitis that leads to irreversible fibrotic lung damage. This study addresses the protective role of the natural flavonoid dihydromyricetin (DHM) against MTX-in...

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Bibliographic Details
Main Authors: Asmaa I. Matouk, Eman M. Awad, Nashwa F. G. El-Tahawy, Azza A. K. El-Sheikh, Aliaa Anter
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceuticals
Subjects:
methotrexate
dihydromyricetin
NF-κB
Nrf2
HO-1
IL-1β
Online Access:https://www.mdpi.com/1424-8247/16/4/481

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