The P72R Polymorphism in R248Q/W p53 Mutants Modifies the Mutant Effect on Epithelial to Mesenchymal Transition Phenotype and Cell Invasion via CXCL1 Expression

The P72R Polymorphism in R248Q/W p53 Mutants Modifies the Mutant Effect on Epithelial to Mesenchymal Transition Phenotype and Cell Invasion via CXCL1 Expression

High-grade serous carcinoma (HGSC), the most lethal subtype of epithelial ovarian cancer (EOC), is characterized by widespread <i>TP53</i> mutations (>90%), most of which are missense mutations (>70%). The objective of this study was to investigate differential transcriptional targ...

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Bibliographic Details
Main Authors: Cristabelle De Souza, Jill A. Madden, Dennis Minn, Vigneshwari Easwar Kumar, Dennis J. Montoya, Roshni Nambiar, Zheng Zhu, Wen-Wu Xiao, Neeki Tahmassebi, Harikumara Kathi, Nina Nelson, Anthony N. Karnezis, Jeremy Chien
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
ovarian cancer
mutant p53
P72R polymorphism
CXCL1
tumor invasion
Online Access:https://www.mdpi.com/1422-0067/21/21/8025

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